Machine learning applied to computer architecture has rapidly transitioned from a theoretical novelty to being a driving force behind design, control, and simulation in practically all components. These machine-learning-based methodologies are further notable for their scalability to increasingly complex design challenges, which has allowed these methodologies to surpass the prior...
To examine the macrophage response to M. avium, I compared inflammasome and cytosolic sensor expression and activation. My result demonstrated that virulent strains of M. avium (A5 and 104) suppress IL-1β production and induce IFN-β production in macrophages. M. avium mutants deficient at DNA export in the biofilm exhibited reduced...
The overall focus of this thesis is on the distribution of specific lipids and membrane proteins of the external and internal membranes of plant cells, in the context of the roles that those lipids and proteins may play in microbe-plant interactions. The work includes the development of several new tools,...
Researchers rely on bioeconomic models to guide research and generate fishery management advice for commercial fisheries. Due partly to a paradigm shift towards ecosystem based fishery management, increasing complexity in the characteristics of the problems has meant that bioeconomic simulation models are becoming more prevalent in the fisheries literature. However...
Over the last several decades, potato production has increased globally as it has been recognized as an important component to improving food security. However, potato production has been continuously challenged by pests. Current pest management practices rely heavily on chemical pesticides. Unfortunately, the overuse of pesticides can be harmful to...
Quaking aspen, Populus tremuloides, has experienced severe declines in recent years in part due to the effects of changing climate and extreme drought. As the dominant deciduous tree in Western North American forests, aspen plays a critical role in forest biodiversity and ecosystem function. Therefore, the persistence of this species...
Back pain is the leading cause of disability worldwide, entailing a significant socioeconomic impact. A primary source of back pain can be attributed to intervertebral disc (IVD) degeneration allowing nerve ingrowth, facet joint arthritis, disc bulging, and osteophyte formations that press on nearby nerve roots or the spinal cord. While...
Molecular chirality plays a critical role in chemistry, biology, and medicine. To study and better understand conformational chirality, it is necessary to obtain structurally interesting molecules that exhibit this form of chirality. Our lab utilizes total synthesis and methodological development to obtain conformationally chiral natural products of interest. We believe...
The tropical Pacific Ocean is a climatically important region, home to El Niño and the Southern Oscillation. The simulation of its climate remains a challenge for global coupled ocean–atmosphere models, which suffer large biases especially in reproducing the observed meridional asymmetry across the equator in sea surface temperature (SST) and...
The coded wire tag (CWT) database contains detailed information on millions of Pacific salmon
Oncorhynchus spp. released from hatcheries or smolt traps and recovered in the north Pacific Ocean and its tributaries. I used this data set to examine the spatial and temporal variation in the marine distributions of 77...