Exposure to urban outdoor air pollution is ubiquitous and low birth weight represents an important health disparity in the United States. While previous research suggests that exposure to outdoor air pollutants are associated with term low birth weight, few studies have evaluated the effects of multipollutant outdoor air exposures or...
Breast cancer is the leading cancer in women with an estimated 13% of women in the United States developing a form of invasive breast cancer in her lifetime. The survival rate is estimated to be 85%, but the American Cancer Society estimates that early detection of breast cancer in the...
Throughout their lifetime individuals are exposed to complex mixtures of chemicals. The study of chemical mixtures is an internationally recognized research priority, but seemingly complex challenge. To reduce the intricacy of studying mixtures, researchers have identified different prioritization methods based on exposure or the toxicity of chemicals. However, understanding the...
Magneto- and chemostratigraphic correlation underpins much of our understanding of Earth history, yet typical correlation techniques are neither quantitative nor objective. Within this dissertation, I detail my efforts to develop and apply dynamic programming-based algorithms that accomplish optimal and reproducible stratigraphic alignment. I apply these algorithms to three geologic intervals:...
Interest is expanding for the potential role of estuaries, particularly seagrass and salt marsh habitats, to sequester carbon, mitigate ocean acidification, and support abundant fisheries. The important functions of estuaries are part of a broader set of ecosystem services, or benefits to humans, which are regulated by ocean and watershed...
Work occupies a considerable amount of time in most peoples’ lives and can be a source of great pleasure or a source of pain. To enhance peoples’ experience at work, we must first understand how to measure and improve the design of work. This research sought to do just that,...
Catastrophic earthquake and tsunami events that resulted in significant loss of life and property over the past two decades have raised the global awareness regarding the need to understand the response of communities and their built environment to multi-hazard extreme events. In recognition to this impending threat to the coastal...
The eruptive history of the Quaternary Cascades arc has been relatively well characterized. However, much less is known about the frequency and sizes of explosive eruptions produced by earlier stages of the arc. The Late Neogene Deschutes Formation of Central Oregon preserves a remarkable record of heightened pyroclastic activity during...
Plant pathogenic Rhodococcus species are persistent pathogens able to cause severe growth deformities on a large range of hosts. The most well studied species, R. fascians is predicted by current models to synthesize a mixture of cytokinins that act to directly perturb the hosts' hormone balances, which results in abnormal...
The field of toxicology is challenged with a vast number of environmental chemicals and mixtures to which humans and ecosystems are exposed with limited toxicity data available. Chemical hazard assessment traditionally utilizes mammalian models and can be both cost- and time-limiting and may pose ethical concerns. To rapidly tackle this...