Cervical cancer is the fourth most common cancer in women worldwide with human papillomavirus (HPV) being the main cause of the disease. Currently available treatment methods are limited and emphasize the need for discovery of new therapies that improve patient outcome. Chromosomal amplifications have been identified as a source of...
As the world population continues to grow we must look for smarter and more sustainable ways to feed everyone. Milk is the first food humans consume and is a good source of protein, fat, and carbohydrates. The following studies sought to determine the effect of feeding blackberry pomace as a...
Recent developments in NMR hardware have extended the reach of natural products chemists to structure elucidation of compounds isolated on a nanomolar scale. In parallel with advances in hardware new NMR techniques for structure elucidation have evolved, e.g. quantitative NOEs, residual dipolar couplings (RDCs)and diffusion-ordered spectroscopy (DOSY). The application of...
The intricate relationship between wildlife health and the quality of their environment is well established, with technological advances increasing our understanding and aiding the unraveling of underlying mechanisms. Large herbivores require forage of sufficient quality to maintain their condition to reproduce and survive, all while warding off parasites and predators...
Carbon nanotubes (CNTs) superior mechanical, electrical and thermal properties make them attractive components in nanomechanical devices. Their large aspect ratio and low density makes them ideal candidates for high frequency resonators in numerous applications including wireless communication, and mass and chemical sensors. One reason why CNTs have been slow to...
Honey bees (Apis mellifera) are responsible for approximately $17 billion in crop production per year in the United States, and are arguably the most important pollinators in the nation. The future of crop pollination and production is threatened by widespread national honey bee colony losses, which have averaged approximately 30%...
The focus of this thesis is to design, characterize, and apply novel computational methods and molecular systems to interrogate heterogeneous human gut microbiome-related phenomena. In Chapter 2, I design, implement, and characterize a method for embedding co-occurrence patterns derived from massive 16s amplicon datasets. I use this method to 1....
Intracellular dNTP pool sizes are highly asymmetric, with dGTP usually comprising 5 to 10% of the sum of the dNTP pools. The work presented in this dissertation addresses the question of whether the underrepresentation of dGTP is related to its potential to be oxidized by reactive oxygen species. 8-oxo-guanine is...
Disease detection through traditional techniques such as scouting fields on foot, molecular assays, or morphological identification of plant pathogens is time consuming and costly. Disease diagnosis in the field can be extremely subjective, and largely depends on the experience and knowledge of pathogen identification and disease quantification. This thesis provides...
A stochastic process is given by a family of random variables indexed by elements of a set. We have considered stochastic processes of three different types, each involving an associated martingale structure. Martingale is a sequence of random variables for which the conditional expectation at a certain time point given...