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- Creator:
- Wells, Brian K., Schroeder, Isaac D., Santora, Jarrod A., Hazen, Elliott L., Bograd, Steven J., Bjorkstedt, Eric P., Loeb, Valerie J., Mcclatchie, Sam, Weber, Edward D., Watson, William, Thompson, Andrew R., Peterson, William T., Brodeur, Richard D., Harding, Jeff, Field, John, Sakuma, Keith, Hayes, Sean, Mantua, Nathan, Sydeman, William J., Losekoot, Marcel, Thompson, Sarah Ann, Largier, John, Kim, Sung Yong, Chavez, Francisco P., Barceló, Caren, Warzybok, Pete, Bradley, Russel, Jahncke, Jaime, Goericke, Ralf, Campbell, Gregory S., Hildebrand, John A., Melin, Sharon R., Delong, Robert L., Gomez-Valdes, Jose, Lavaniegos, Bertha, Gaxiola-Castro, Gilberto, Golightly, Richard T., Schneider, Stephanie R., Lo, Nancy, Suryan, Robert M., Gladics, Amanda J., Horton, Cheryl A., Fisher, Jennifer, Morgan, Cheryl, Peterson, Jay, Daly, Elizabeth A., Auth, Toby D., and Abell, Jeffrey
- Abstract:
- This report reviews the state of the California Current System (CCS) between winter 2012 and spring 2013, and includes observations from Washington State to Baja California. During 2012, large-scale climate modes indicated the CCS remained in a cool, productive phase present since 2007. The upwelling season was delayed north of...
- Full Text:
- SHARON R. MELIN, ROBERT L. DELONG National Marine Fisheries Service Alaska Fisheries Science Center
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- Creator:
- Wells, Brian K., Schroeder, Isaac D., Santora, Jarrod A., Hazen, Elliott L., Bograd, Steven J., Bjorkstedt, Eric P., Loeb, Valerie J., Mcclatchie, Sam, Weber, Edward D., Watson, William, Thompson, Andrew R., Peterson, William T., Brodeur, Richard D., Harding, Jeff, Field, John, Sakuma, Keith, Hayes, Sean, Mantua, Nathan, Sydeman, William J., Losekoot, Marcel, Thompson, Sarah Ann, Largier, John, Kim, Sung Yong, Chavez, Francisco P., Barceló, Caren, Warzybok, Pete, Bradley, Russel, Jahncke, Jaime, Goericke, Ralf, Campbell, Gregory S., Hildebrand, John A., Melin, Sharon R., Delong, Robert L., Gomez-Valdes, Jose, Lavaniegos, Bertha, Gaxiola-Castro, Gilberto, Golightly, Richard T., Schneider, Stephanie R., Lo, Nancy, Suryan, Robert M., Gladics, Amanda J., Horton, Cheryl A., Fisher, Jennifer, Morgan, Cheryl, Peterson, Jay, Daly, Elizabeth A., Auth, Toby D., and Abell, Jeffrey
- Abstract:
- This report reviews the state of the California Current System (CCS) between winter 2012 and spring 2013, and includes observations from Washington State to Baja California. During 2012, large-scale climate modes indicated the CCS remained in a cool, productive phase present since 2007. The upwelling season was delayed north of...
- Full Text:
- 0.20 0.30 0.40 0.50 0.60 Chlorophyll a (µg L-1) B: CCurrent South 0 20 40 60 80 100 120 140
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- Creator:
- Wells, Brian K., Schroeder, Isaac D., Santora, Jarrod A., Hazen, Elliott L., Bograd, Steven J., Bjorkstedt, Eric P., Loeb, Valerie J., Mcclatchie, Sam, Weber, Edward D., Watson, William, Thompson, Andrew R., Peterson, William T., Brodeur, Richard D., Harding, Jeff, Field, John, Sakuma, Keith, Hayes, Sean, Mantua, Nathan, Sydeman, William J., Losekoot, Marcel, Thompson, Sarah Ann, Largier, John, Kim, Sung Yong, Chavez, Francisco P., Barceló, Caren, Warzybok, Pete, Bradley, Russel, Jahncke, Jaime, Goericke, Ralf, Campbell, Gregory S., Hildebrand, John A., Melin, Sharon R., Delong, Robert L., Gomez-Valdes, Jose, Lavaniegos, Bertha, Gaxiola-Castro, Gilberto, Golightly, Richard T., Schneider, Stephanie R., Lo, Nancy, Suryan, Robert M., Gladics, Amanda J., Horton, Cheryl A., Fisher, Jennifer, Morgan, Cheryl, Peterson, Jay, Daly, Elizabeth A., Auth, Toby D., and Abell, Jeffrey
- Abstract:
- This report reviews the state of the California Current System (CCS) between winter 2012 and spring 2013, and includes observations from Washington State to Baja California. During 2012, large-scale climate modes indicated the CCS remained in a cool, productive phase present since 2007. The upwelling season was delayed north of...
- Resource Type:
- Article
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- Creator:
- Roberts, Blaine R., Lim, Nastasia K. H., McAllum, Erin J., Donnelly, Paul S., Hare, Dominic J., Doble, Philip A., Turner, Bradley J., Price, Katherine A., Lim, Sin Chun, Paterson, Brett M., Hickey, James L., Rhoads, Timothy W., Williams, Jared R., Kanninen, Katja M., Hung, Lin W., Liddell, Jeffrey R., Grubman, Alexandra, Monty, Jean-Francois, Llanos, Roxana M., Kramer, David R., Mercer, Julian F. B., Bush, Ashley I., Masters, Colin L., Duce, James A., Li, Qiao-Xin, Beckman, Joseph S., Barnham, Kevin J., White, Anthony R., and Crouch, Peter J.
- Abstract:
- Mutations in the metallo-protein Cu/Zn-superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS) in humans and an expression level-dependent phenotype in transgenic rodents. We show that oral treatment with the therapeutic agent diacetyl-bis(4-methylthiosemicarbazonato)copper[superscript II] [Cu[superscript II](atsm)] increased the concentration of mutant SOD1 (SOD1G37R) in ALS model mice, but paradoxically improved locomotor...
- Resource Type:
- Article
- Full Text:
- Brett M. Paterson,3,4 James L. Hickey,3,4 Timothy W. Rhoads,7,8 Jared R. Williams,7,8 Katja M. Kanninen
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- Creator:
- Jacobson, Terry A., Maki, Kevin C., Orringer, Carl E., Jones, Peter H., Kris-Etherton, Penny, Sikand, Geeta, La Forge, Ralph, Daniels, Stephen R., Wilson, Don P., Morris, Pamela B., Wild, Robert A., Grundy, Scott M., Daviglus, Martha, Ferdinand, Keith C., Vijayaraghavan, Krishnaswami, Deedwania, Prakash C., Aberg, Judith A., Liao, Katherine P., McKenney, James M., Ross, Joyce L., Braun, Lynne T., Ito, Matthew K., Bays, Harold E., Brown, W. Virgil, Underberg, James A., and NLA Expert Panel
- Abstract:
- An Expert Panel convened by the National Lipid Association previously developed a consensus set of recommendations for the patient-centered management of dyslipidemia in clinical medicine (part 1). These were guided by the principle that reducing elevated levels of atherogenic cholesterol (non–high-density lipoprotein cholesterol and low-density lipoprotein cholesterol) reduces the risk...
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- Creator:
- Jacobson, Terry A., Maki, Kevin C., Orringer, Carl E., Jones, Peter H., Kris-Etherton, Penny, Sikand, Geeta, La Forge, Ralph, Daniels, Stephen R., Wilson, Don P., Morris, Pamela B., Wild, Robert A., Grundy, Scott M., Daviglus, Martha, Ferdinand, Keith C., Vijayaraghavan, Krishnaswami, Deedwania, Prakash C., Aberg, Judith A., Liao, Katherine P., McKenney, James M., Ross, Joyce L., Braun, Lynne T., Ito, Matthew K., Bays, Harold E., Brown, W. Virgil, Underberg, James A., and NLA Expert Panel
- Abstract:
- An Expert Panel convened by the National Lipid Association previously developed a consensus set of recommendations for the patient-centered management of dyslipidemia in clinical medicine (part 1). These were guided by the principle that reducing elevated levels of atherogenic cholesterol (non–high-density lipoprotein cholesterol and low-density lipoprotein cholesterol) reduces the risk...
- Full Text:
- , Ralph La Forge, MSc, Stephen R. Daniels, MD, PhD, Don P. Wilson, MD, Pamela B. Morris, MD, Robert A
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- Creator:
- Jacobson, Terry A., Maki, Kevin C., Orringer, Carl E., Jones, Peter H., Kris-Etherton, Penny, Sikand, Geeta, La Forge, Ralph, Daniels, Stephen R., Wilson, Don P., Morris, Pamela B., Wild, Robert A., Grundy, Scott M., Daviglus, Martha, Ferdinand, Keith C., Vijayaraghavan, Krishnaswami, Deedwania, Prakash C., Aberg, Judith A., Liao, Katherine P., McKenney, James M., Ross, Joyce L., Braun, Lynne T., Ito, Matthew K., Bays, Harold E., Brown, W. Virgil, Underberg, James A., and NLA Expert Panel
- Abstract:
- An Expert Panel convened by the National Lipid Association previously developed a consensus set of recommendations for the patient-centered management of dyslipidemia in clinical medicine (part 1). These were guided by the principle that reducing elevated levels of atherogenic cholesterol (non–high-density lipoprotein cholesterol and low-density lipoprotein cholesterol) reduces the risk...
- Resource Type:
- Article
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- Creator:
- Miadlikowska, Jolanta, Kauff, Frank, Högnabba, Filip, Oliver, Jeffrey C., Molnár, Katalin, Fraker, Emily, Gaya, Ester, Hafellner, Josef, Hofstetter, Valérie, Gueidan, Cécile, Otálora, Mónica A. G., Hodkinson, Brendan, Kukwa, Martin, Lücking, Robert, Björk, Curtis, Sipman, Harrie J. M., Burgaz, Ana R., Thell, Arne, Passo, Alfredo, Myllys, Leena, Goward, Trevor, Fernández-Brime, Samantha, Hestmark, Geir, Lendemer, James, Lumbsch, H. Thorsten, Schmull, Michaela, Schoch, Conrad L., Sérusiaux, Emmanuël, Arnold, A. Elizabeth, Maddison, David R., Lutzoni, François, and Stenroos, Soili
- Abstract:
- The Lecanoromycetes is the largest class of lichenized Fungi, and one of the most species-rich classes in the kingdom. Here we provide a multigene phylogenetic synthesis (using three ribosomal RNA-coding and two protein-coding genes) of the Lecanoromycetes based on 642 newly generated and 3329 publicly available sequences representing 1139 taxa,...
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- Article
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- Creator:
- Rick, Torben C., Sillett, T. Scott, Ghalambor, Cameron K., Hofman, Courtney A., Ralls, Katherine, Anderson, R. Scott, Boser, Christina L., Braje, Todd J., Cayan, Daniel R., Chesser, R. Terry, Collins, Paul W., Erlandson, Jon M., Faulkner, Kate R., Fleischer, Robert, Funk, W. Chris, Galipeau, Russell, Huston, Ann, King, Julie, Laughrin, Lyndal, Maldonado, Jesus, McEachern, Kathryn, Muhs, Daniel R., Newsome, Seth D., Reeder-Myers, Leslie, Still, Christopher, and Morrison, Scott A.
- Abstract:
- Historical ecology is becoming an important focus in conservation biology and offers a promising tool to help guide ecosystem management. Here, we integrate data from multiple disciplines to illuminate the past, present, and future of biodiversity on California’s Channel Islands, an archipelago that has undergone a wide range of land-use...
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- Article
- Full Text:
- , CHRISTINA L. BOSER, TODD J. BRAJE, DANIEL R. CAYAN, R. TERRY CHESSER, PAUL W. COLLINS, JON M. ERLANDSON
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- Creator:
- Adams, Paul D., Aertgeerts, Kathleen, Bauer, Cary, Bell, Jeffrey A., Berman, Helen M., Bhat, Talapady N., Blaney, Jeff M., Bolton, Evan, Bricogne, Gerard, Brown, David, Burley, Stephen K., Case, David A., Clark, Kirk L., Darden, Tom, Emsley, Paul, Feher, Victoria A., Feng, Zukang, Groom, Colin R., Harris, Seth F., Hendle, Jorg, Holder, Thomas, Joachimiak, Andrzej, Kleywegt, Gerard J., Krojer, Tobias, Marcotrigiano, Joseph, Mark, Alan E., Markley, John L., Miller, Matthew, Minor, Wladek, Montelione, Gaetano T., Murshudov, Garib, Nakagawa, Atsushi, Nakamura, Haruki, Nicholls, Anthony, Nicklaus, Marc, Nolte, Robert T., Padyana, Anil K., Peishoff, Catherine E., Pieniazek, Susan, Read, Randy J., Shao, Chenghua, Sheriff, Steven, Smart, Oliver, Soisson, Stephen, Spurlino, John, Stouch, Terry, Svobodova, Radka, Tempel, Wolfram, Terwilliger, Thomas C., Tronrud, Dale, Velankar, Sameer, Ward, Suzanna C., Warren, Gregory L., Westbrook, John D., Williams, Pamela, Yang, Huanwang, and Young, Jasmine
- Abstract:
- Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
- Full Text:
- L. Clark, Tom Darden, Paul Emsley, Victoria A. Feher, Zukang Feng, Colin R. Groom, Seth F. Harris