Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms
linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family
members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
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, James C, Josefsson EC et al.
Deciphering the molecular and biological processes that mediate histone
Litter decomposition is a keystone ecosystem process impacting nutrient cycling and productivity, soil properties, and the terrestrial carbon (C) balance, but the factors regulating decomposition rate are still poorly understood. Traditional models assume that the rate is controlled by litter quality, relying on parameters such as lignin content as predictors....
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www.pnas.org/cgi/doi/10.1073/pnas.1508945112 PNAS | Published online September 8, 2015 | E5253–E5260
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Many bacteria possess cell density-dependent quorum-sensing (QS) systems that often regulate cooperative secretions involved
in host-microbe or microbe-microbe interactions. These secretions, or “public goods,” are frequently coregulated by stress and
starvation responses. Here we provide a physiological rationale for such regulatory complexity in the opportunistic pathogen
Pseudomonas aeruginosa. Using minimal-medium...
Wood is a major pool of organic carbon that is highly resistant to decay, owing largely to the presence of lignin. The only organisms capable of substantial lignin decay are white rot fungi in the Agaricomycetes, which also contains non–lignin-degrading brown rot and ectomycorrhizal species. Comparative analyses of 31 fungal...
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://www.expasy.org/sprot/), KEGG (20), and KOG (21). KEGG hits were used to assign EC
numbers (http://www.expasy.org
INTRODUCTION: Between 2004 and 2010, the number of home births in the United States rose by 41%, increasing the need for accurate assessment of the safety of planned home birth. This study examines outcomes of planned home births in the United States between 2004 and 2009.
METHODS: We calculated descriptive...
Intraspecific life history attributes of growth, survival, and reproduction can vary in
response to changes in the physical environment. These changes can induce a cascading effect
across trophic levels. In marine systems, shifts in ocean conditions such as warm and cold phases
of ENSO can change primary production in benthic...
Benton County has experienced substantial growth in the past 30 years, and is expected to continue growing (BCWP 2008). Continued development has occurred in the Willamette Valley, housing development in the nearby hills of the Coast Range is growing. New houses in the foothills of the Coast Range may not...
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The American Land Institute is proud to present this study, Oregon’s Public Investment in Conservation, Prosperity and Fairness. This is the first major study on a topic that has been largely overlooked in past and current discussions of land use law in Oregon: the nature and extent of property tax...
How does transboundary water cooperation begin at the initial stages? Countries in many transboundary basins either do not cooperate at all or have ceased cooperation altogether. Yet cooperation does often prevail, resulting in 688 water-related treaties signed between 1820 and 2007. The question we address here is, by which practices...