Cancer risk at low-dose ionizing radiation has been the subject of great scientific controversy in the past century. The clear majority of national and international radiation protection regulators adopt the linear no-threshold (LNT) model based on the atomic-bomb survivors Life Span Study (LSS) for solid cancer risk assessment. The LNT...
Propolis is a gummy material produced by honey bees to protect their hives and currently has drawn the attention of researchers due to its broad clinical use. It has been reported, based only on observations, that honey bees also collect other non-vegetation substances such as paint or asphalt/tar to make...
Factors influencing the emergence of collective action are studied using survey data from individual boat owners from Barka, Masn’a and Suwaiq. Fishermen who adopt a cooperative strategy tend to be more risk averse and have high economic dependence on the common property resources. Social identity as a fisherman also appears...
A transient code (TFETC) for calculating the temperature
distribution throughout the radial and axial positions of a
thermionic fuel element (TFE) has been successfully developed.
It accommodates the variations of temperatures, thermal power,
electrical power, voltage, and current density throughout the
TFE as a function of time as well as...
Capture-recapture studies offer a powerful tool to assess abundance, survival and population rate of change (λ). A previous capture-recapture study, based on DNA profiles, estimated that the IUCN-listed Endangered Oceania population of humpback whales had a superpopulation size of 4329 whales (95% confidence limits, CL: 3345, 5315) and λ =...
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. Carroll*, L. Brooks, C. S Baker, D. Burns, C. Garrigue, N. Hauser, J. A. Jackson,
M. M. Poole, R. M
Capture-recapture studies offer a powerful tool to assess abundance, survival and population rate of change (λ). A previous capture-recapture study, based on DNA profiles, estimated that the IUCN-listed Endangered Oceania population of humpback whales had a superpopulation size of 4329 whales (95% confidence limits, CL: 3345, 5315) and λ =...
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Fidelity to migratory destinations is an important driver of connectivity in marine and avian species. Here we assess the role of maternally directed learning of migratory habitats, or migratory culture, on the population structure of the endangered Australian and New Zealand southern right whale. Using DNA profiles, comprising mitochondrial DNA...
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DNA sequence polymorphism data. Evolution
(N. Y). 55, 1678–1685 (2001).
21. Ho, S. Y. W. et al
Fidelity to migratory destinations is an important driver of connectivity in marine and avian species. Here we assess the role of maternally directed learning of migratory habitats, or migratory culture, on the population structure of the endangered Australian and New Zealand southern right whale. Using DNA profiles, comprising mitochondrial DNA...
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. 80, 2140–2158 (2012).
10. Baker, C. S. et al. Strong maternal fidelity and natal philopatry shape
Emerging application areas such as air pollution in megacities, wind energy, urban security, and operation of unmanned aerial vehicles have intensified scientific and societal interest in mountain meteorology. To address scientific needs and help improve the prediction of mountain weather, the U.S. Department of Defense has funded a research effort—the...
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MATERHORN: Unraveling the Intricacies of Mountain Weather,” by H. J. S. Fernando,
E. R. Pardyjak, S. Di
Emerging application areas such as air pollution in megacities, wind energy, urban security, and operation of unmanned aerial vehicles have intensified scientific and societal interest in mountain meteorology. To address scientific needs and help improve the prediction of mountain weather, the U.S. Department of Defense has funded a research effort—the...
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of Mountain Weather
Fernando, H. J. S., Pardyjak, E. R., Di Sabatino, S., Chow, F. K., De Wekker, S
The terrestrial biosphere sequesters up to a
third of annual anthropogenic carbon dioxide emissions,
offsetting a substantial portion of greenhouse
gas forcing of the climate system. Although a number
of factors are responsible for this terrestrial carbon
sink, atmospheric nitrogen deposition contributes by
enhancing tree productivity and promoting carbon
storage...
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(Saiya-Cork et al. 2002). Field-moist soil was sieved to < 2 mm,
homogenized 30 s in modified universal
The terrestrial biosphere sequesters up to a
third of annual anthropogenic carbon dioxide emissions,
offsetting a substantial portion of greenhouse
gas forcing of the climate system. Although a number
of factors are responsible for this terrestrial carbon
sink, atmospheric nitrogen deposition contributes by
enhancing tree productivity and promoting carbon
storage...
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: Solomon S et al (eds) Climate
change 2007: the physical science basis. Contribution of
working group I
Significant seabird mortality on the Oregon (OR) and Washington (WA) coast in 2009 has been attributed
to a massive bloom of the dinoflagellate Akashiwo sanguinea (K. Hirasaka) G. Hansen & Ø. Moestrup.
Initial, albeit limited, observations suggested this bloom began in WA and reached OR waters through
southward transport. Here,...
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. White a,*, Katie S. Watkins-Brandt a, S. Morgaine McKibben a,
A. Michelle Wood b, Matthew Hunter c, Zach
Significant seabird mortality on the Oregon (OR) and Washington (WA) coast in 2009 has been attributed
to a massive bloom of the dinoflagellate Akashiwo sanguinea (K. Hirasaka) G. Hansen & Ø. Moestrup.
Initial, albeit limited, observations suggested this bloom began in WA and reached OR waters through
southward transport. Here,...
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Northern California
current system in 2009
White, A. E., Watkins-Brandt, K. S., McKibben, S. M., Wood, A
We use autonomous gas measurements to examine the metabolic balance (photosynthesis
minus respiration) of coastal Antarctic waters during the spring/summer growth season. Our observations
capture the development of a massive phytoplankton bloom and reveal striking variability in pCO₂ and
biological oxygen saturation (ΔO₂/Ar) resulting from large shifts in community metabolism...
We use autonomous gas measurements to examine the metabolic balance (photosynthesis
minus respiration) of coastal Antarctic waters during the spring/summer growth season. Our observations
capture the development of a massive phytoplankton bloom and reveal striking variability in pCO₂ and
biological oxygen saturation (ΔO₂/Ar) resulting from large shifts in community metabolism...
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, Joseph J. Grzymski6, Jodi N. Young4, Sven A. Kranz4, Kim S. Bernard7
1Department of Earth, Ocean
We use autonomous gas measurements to examine the metabolic balance (photosynthesis
minus respiration) of coastal Antarctic waters during the spring/summer growth season. Our observations
capture the development of a massive phytoplankton bloom and reveal striking variability in pCO₂ and
biological oxygen saturation (ΔO₂/Ar) resulting from large shifts in community metabolism...
Hydroacoustic data document the occurrence of 5 flare clusters and several single flares from which bubbles rise through the entire water column from an active seep site at 40 m water depth in the central North Sea. We investigated the difference in dissolved methane distributions along a 6 km transect...
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the central North Sea
S. Mau et al.
Correspondence to:S. Mau (smau@marum.de)
The MOx values
Hydroacoustic data document the occurrence of 5 flare clusters and several single flares from which bubbles rise through the entire water column from an active seep site at 40 m water depth in the central North Sea. We investigated the difference in dissolved methane distributions along a 6 km transect...
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site
S. Mau et al.
Title Page
Abstract Introduction
Conclusions References
Tables Figures
J I
J
We investigated dissolved methane distributions along a 6 km transect crossing active seep sites at 40 m water depth in the central North Sea. These investigations were done under conditions of thermal stratification in summer (July 2013) and homogenous water column in winter (January 2014). Dissolved methane accumulated below the...
We investigated dissolved methane distributions along a 6 km transect crossing active seep sites at 40 m water depth in the central North Sea. These investigations were done under conditions of thermal stratification in summer (July 2013) and homogenous water column in winter (January 2014). Dissolved methane accumulated below the...
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Copernicus Publications on behalf of the European Geosciences Union.
5262 S. Mau et al.: Seasonal methane
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
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0.26 0.15
Jenner et al., 2012 Se (LA-ICP-MS) 0.385 0.401 0.339 0.349 0.341 0.340 0.314 0.308 0.358
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
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10.9 *** 0.91
209 Bi 0.04 0.05 0.05 9.75 0.050 *** 0.94
*PV from Jouchum et al. 2005
**Additional
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
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:11 22°30.90’ S 176°41.17’ W 2000 1: Black andesite pillows, typically 1-5 cm thick with glass
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
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Frances E. Jennera,b*, Erik H. Haurib, Emma S. Bullockc, Stephan Königd, Richard J. Arculuse, John
A
There is a lack of consensus regarding the roles of sulfide saturation versus volatile degassing on the partitioning of Cu and Ag during differentiation and eruption of convergent margin magmas. Because of their oxidized character, volatile-rich magmas from the Eastern Manus Back-arc Basin (EMBB) only reach sulfide saturation following magnetite-driven...
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/RFe, such as those from Augustine, have <6000
ppm S [e.g., Kelley and Cottrell, 2009; Zimmer et al
The 1994 Northwest Forest Plan (NWFP) shifted federal lands management from a focus on timber production to ecosystem management and biodiversity conservation. The plan established a network of conservation reserves and an ecosystem management strategy on ~10 million hectares from northern California to Washington State, USA, within the range of...
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Correction: DellaSala, D.A., et al. Building on Two
The 1994 Northwest Forest Plan (NWFP) shifted federal lands management from a focus on timber production to ecosystem management and biodiversity conservation. The plan established a network of conservation reserves and an ecosystem management strategy on ~10 million hectares from northern California to Washington State, USA, within the range of...
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., Heiken, D., Frissell, C. A., Karr, J. R., Nelson, S. K., ...
& Strittholt, J. (2015). Building on Two
BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
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, Iversen PL, et al. AVI-7288 for Marburg virus in nonhuman primates and
humans. N Engl J Med 2015;373:339
BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
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Identifying Information Section 1.
1. Given Name (First Name)
Mohamed
2. Surname (Last Name)
Al-Ibrahim
BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
Full Text:
, Charleston JS, Iversen PL, et al. AVI-7288 for Marburg virus in nonhuman primates
and humans. N Engl J Med
BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
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Nonhuman Primates and Humans
Alison E. Heald, M.D., Jay S. Charleston, Ph.D., Patrick L. Iversen, Ph.D
BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
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Humans
Heald, A. E., Charleston, J. S., Iversen, P. L., Warren, T. K., Saoud, J. B.,
Al-Ibrahim, M
Contributing to the worldwide biodiversity crisis are emerging infectious diseases, which can lead to extirpations and extinctions of hosts. For example, the infectious fungal pathogen Batrachochytrium dendrobatidis (Bd) is associated with worldwide amphibian population declines and extinctions. Sensitivity to Bd varies with species, season, and life stage. However, there is...
Contributing to the worldwide biodiversity crisis are emerging infectious diseases, which can lead to extirpations and extinctions of hosts. For example, the infectious fungal pathogen Batrachochytrium dendrobatidis (Bd) is associated with worldwide amphibian population declines and extinctions. Sensitivity to Bd varies with species, season, and life stage. However, there is...
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fungal pathogen Batrachochytrium
dendrobatidis among amphibian populations
Bradley, P. W., Gervasi, S
Pathogens often have negative effects on wildlife populations, and disease management strategies are important for mitigating opportunities for pathogen transmission. Bovine tuberculosis (Mycobacterium bovis; BTB) is widespread among African buffalo (Syncerus caffer) populations in southern Africa, and strategies for managing this disease vary. In two high profile parks, Kruger National...
Pathogens often have negative effects on wildlife populations, and disease management strategies are important for mitigating opportunities for pathogen transmission. Bovine tuberculosis (Mycobacterium bovis; BTB) is widespread among African buffalo (Syncerus caffer) populations in southern Africa, and strategies for managing this disease vary. In two high profile parks, Kruger National...
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African buffalo
Lane-deGraaf, K. E., Amish, S. J., Gardipee, F., Jolles, A., Luikart, G., & Ezenwa,
V. O
A suite of eight rocks analyzed by the Curiosity Rover while it was stopped at the Rocknest sand
ripple shows the greatest chemical divergence of any potentially sedimentary rocks analyzed in the early
part of the mission. Relative to average Martian soil and to the stratigraphically lower units encountered as...
A suite of eight rocks analyzed by the Curiosity Rover while it was stopped at the Rocknest sand
ripple shows the greatest chemical divergence of any potentially sedimentary rocks analyzed in the early
part of the mission. Relative to average Martian soil and to the stratigraphically lower units encountered as...
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Compositions [from Schmidt et al., 2014]a
SiO2 TiO2 Al2O3 FeOT MgO CaO Na2O K2O
Total Oxide
(no S) SO3
1. Despite their importance in determining the rate of both energy gain and expenditure, how
the fine-scale kinematics of foraging are modified in response to changes in prey abundance
and distribution remain poorly understood in many animal ecosystems.
2. In the marine environment, bulk-filter feeders rely on dense aggregations of...
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. Goldbogen, Elliott L. Hazen, Ari S. Friedlaender, John
Calambokidis, Stacy L. DeRuiter, Alison K. Stimpert
1. Despite their importance in determining the rate of both energy gain and expenditure, how
the fine-scale kinematics of foraging are modified in response to changes in prey abundance
and distribution remain poorly understood in many animal ecosystems.
2. In the marine environment, bulk-filter feeders rely on dense aggregations of...
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mechanism to filter prey-laden water at an estimated
rate of 3–5 m3 s�1 (Werth 2004; Simon et al. 2009
Management of marine ecosystems increasingly demands comprehensive and quantitative assessments of ocean health,
but lacks a tool to do so. We applied the recently developed Ocean Health Index to assess ocean health in the relatively
data-rich US west coast region. The overall region scored 71 out of 100, with sub-regions...
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the global assessment (Halpern et al. 2012). Additional details can also be found in the
supporting
Management of marine ecosystems increasingly demands comprehensive and quantitative assessments of ocean health,
but lacks a tool to do so. We applied the recently developed Ocean Health Index to assess ocean health in the relatively
data-rich US west coast region. The overall region scored 71 out of 100, with sub-regions...
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(Table 3). For large countries with coasts spanning sizable
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Pathogens often have negative effects on wildlife populations, and disease management strategies are important for mitigating opportunities for pathogen transmission. Bovine tuberculosis (Mycobacterium bovis; BTB) is widespread among African buffalo (Syncerus caffer) populations in southern Africa, and strategies for managing this disease vary. In two high profile parks, Kruger National...
Revised July 1989. Reprinted July 1988. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
BACKGROUND:
AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets the viral messenger RNA that encodes Marburg virus (MARV) nucleoprotein. Its safety in humans is undetermined.
METHODS:
We assessed the efficacy of AVI-7288 in a series of studies involving a lethal challenge with MARV in nonhuman primates. The...
Background: The uneven distribution of recombination across the length of chromosomes results in inaccurate estimates of genetic to physical distances. In wheat (Triticum aestivum L.) chromosome 3B, it has been estimated that 90% of the cross over events occur in distal sub-telomeric regions representing 40% of the chromosome. Radiation hybrid...
The Leguminosae has emerged as a model for studying angiosperm plastome evolution because of its striking diversity of structural rearrangements and sequence variation. However, most of what is known about legume plastomes comes from few genera representing a subset of lineages in subfamily Papilionoideae. We investigate plastome evolution in subfamily...
Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically,...
The Geostationary Coastal and Air Pollution Events (GEO-CAPE) mission was recommended by the National Research Council's (NRC's) Earth Science Decadal Survey to measure tropospheric trace gases and aerosols and coastal ocean phytoplankton, water quality, and biogeochemistry from geostationary orbit, providing continuous observations within the field of view. To fulfill the...
Potentially carcinogenic compounds may cause cancer through direct DNA damage or through indirect cellular or physiological effects. To study possible carcinogens, the fields of endocrinology, genetics, epigenetics, medicine, environmental health, toxicology, pharmacology and oncology must be considered. Disruptive chemicals may also contribute to multiple stages of tumor development through effects...
Genome instability is a prerequisite for the development of cancer. It occurs when genome maintenance systems fail to safeguard the genome’s integrity, whether as a consequence of inherited defects or induced via exposure to environmental agents (chemicals, biological agents and radiation). Thus, genome instability can be defined as an enhanced...
As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth...
Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that...