Search Constraints
Filtering by:
Creator
Ayres, James Lee
Remove constraint Creator: Ayres, James Lee
Date
Unknown
Remove constraint Date: Unknown
1 - 16 of 16
Number of results to display per page
Search Results
-
- Creator:
- Nguyen, Chien, Christensen, J. Mark, and Ayres, James W.
- Abstract:
- A promising formulation of glipizide comprising compression of four-layer coated beads into tablets which has advantages of providing a lag time (~ 2 hours) before drug release, retaining sustained-release characteristics, and providing approximately zero-order drug release, with drug release nearly independent of paddle speeds of 50 and 100 rpm during...
-
- Creator:
- Nguyen, Chien, Christensen, J. Mark, and Ayres, James W.
- Abstract:
- A promising formulation of glipizide comprising compression of four-layer coated beads into tablets which has advantages of providing a lag time (~ 2 hours) before drug release, retaining sustained-release characteristics, and providing approximately zero-order drug release, with drug release nearly independent of paddle speeds of 50 and 100 rpm during...
-
- Creator:
- Nguyen, Chien, Christensen, J. Mark, and Ayres, James W.
- Abstract:
- A promising formulation of glipizide comprising compression of four-layer coated beads into tablets which has advantages of providing a lag time (~ 2 hours) before drug release, retaining sustained-release characteristics, and providing approximately zero-order drug release, with drug release nearly independent of paddle speeds of 50 and 100 rpm during...
-
- Creator:
- Mitchell, Logan, Brook, Edward J., Lee, James E., Buizert, Christo, and Sowers, Todd
- Abstract:
- The origin of the late pre-industrial Holocene (LPIH) increase in atmospheric methane concentrations has been much debated. Hypotheses invoking changes in solely anthropogenic sources or solely natural sources have been proposed to explain the increase in concentrations. Here two high-resolution, high-precision ice core methane concentration records from Greenland and Antarctica...
- Full Text:
- Anthropogenic Contribution to the Atmospheric Methane Budget Logan Mitchell,* Ed Brook, James E. Lee, Christo
-
- Creator:
- Mitchell, Logan, Brook, Edward J., Lee, James E., Buizert, Christo, and Sowers, Todd
- Abstract:
- The origin of the late pre-industrial Holocene (LPIH) increase in atmospheric methane concentrations has been much debated. Hypotheses invoking changes in solely anthropogenic sources or solely natural sources have been proposed to explain the increase in concentrations. Here two high-resolution, high-precision ice core methane concentration records from Greenland and Antarctica...
-
- Creator:
- Speight, Lee C., Muthusamy, Anand K., Goldberg, Jacob M., Warner, John B., Wissner, Rebecca F., Willi, Taylor S., Woodman, Bradley F., Mehl, Ryan A., and Petersson, E. James
- Abstract:
- The amino acid acridon-2-ylalanine (Acd) can be a valuable probe of protein conformational change because it is a long lifetime, visible wavelength fluorophore that is small enough to be incorporated during ribosomal biosynthesis. Incorporation of Acd into proteins expressed in E. coli requires efficient chemical synthesis to produce large quantities...
- Full Text:
- Fluorescent Amino Acid for Lifetime and FRET/LRET Studies Lee C. Speight,† Anand K. Muthusamy,† Jacob M
-
- Creator:
- Speight, Lee C., Muthusamy, Anand K., Goldberg, Jacob M., Warner, John B., Wissner, Rebecca F., Willi, Taylor S., Woodman, Bradley F., Mehl, Ryan A., and Petersson, E. James
- Abstract:
- The amino acid acridon-2-ylalanine (Acd) can be a valuable probe of protein conformational change because it is a long lifetime, visible wavelength fluorophore that is small enough to be incorporated during ribosomal biosynthesis. Incorporation of Acd into proteins expressed in E. coli requires efficient chemical synthesis to produce large quantities...
- Full Text:
- FRET/LRET Studies Lee C. Speight,† Anand K. Muthusamy,† Jacob M. Goldberg,† John B. Warner,† Rebecca
-
- Creator:
- Hewson, Ian, Eggleston, Erin M., Doherty, Mary, Lee, Dong Yoon, Owens, Michael, Shapleigh, James P., Cornwell, Jeffrey C., and Crump, Byron C.
- Abstract:
- We used metatranscriptomics to study the gene transcription patterns of microbial plankton (0.2 to 64 μm) at a mesohaline station in the Chesapeake Bay under transitions from oxic to anoxic waters in spring and from anoxic to oxic waters in autumn. Samples were collected from surface (i.e., above pycnocline) waters...
- Full Text:
- Bay during Oxic-Anoxic-Oxic Transitions Hewson, I., Eggleston, E. M., Doherty, M., Lee, D. Y., Owens
-
- Creator:
- Hewson, Ian, Eggleston, Erin M., Doherty, Mary, Lee, Dong Yoon, Owens, Michael, Shapleigh, James P., Cornwell, Jeffrey C., and Crump, Byron C.
- Abstract:
- We used metatranscriptomics to study the gene transcription patterns of microbial plankton (0.2 to 64 μm) at a mesohaline station in the Chesapeake Bay under transitions from oxic to anoxic waters in spring and from anoxic to oxic waters in autumn. Samples were collected from surface (i.e., above pycnocline) waters...
-
- Creator:
- Shcherbina, Andrey Y., Sundermeyer, Miles A., Kunze, Eric, D'Asaro, Eric, Badin, Gualtiero, Birch, Daniel, Brunner-Suzuki, Anne-Marie E. G., Callies, Jörn, Kuebel Cervantes, Brandy T., Claret, Mariona, Concannon, Brian, Early, Jeffrey, Ferrari, Raffaele, Goodman, Louis, Harcourt, Ramsey R., Klymak, Jody M., Lee, Craig M., Lelong, M.-Pascale, Levine, Murray D., Lien, Ren-Chieh, Mahadevan, Amala, McWilliams, James C., Molemaker, M. Jeroen, Mukherjee, Sonaljit, Nash, Jonathan D., Özgökmen, Tamay, Pierce, Stephen D., Ramachandran, Sanjiv, Samelson, Roger M., Sanford, Thomas B., Shearman, R. Kipp, Skyllingstad, Eric D., Smith, K. Shafer, Tandon, Amit, Taylor, John R., Terray, Eugene A., Thomas, Leif N., and Ledwell, James R.
- Abstract:
- Lateral stirring is a basic oceanographic phenomenon affecting the distribution of physical, chemical, and biological fields. Eddy stirring at scales on the order of 100 km (the mesoscale) is fairly well understood and explicitly represented in modern eddy-resolving numerical models of global ocean circulation. The same cannot be said for...
- Resource Type:
- Article
- Full Text:
- , Louis Goodman, Ramsey R. Harcourt, Jody M. Klymak, Craig M. Lee, M.-Pascale Lelong, Murray D. Levine
-
- Creator:
- Shcherbina, Andrey Y., Sundermeyer, Miles A., Kunze, Eric, D'Asaro, Eric, Badin, Gualtiero, Birch, Daniel, Brunner-Suzuki, Anne-Marie E. G., Callies, Jörn, Kuebel Cervantes, Brandy T., Claret, Mariona, Concannon, Brian, Early, Jeffrey, Ferrari, Raffaele, Goodman, Louis, Harcourt, Ramsey R., Klymak, Jody M., Lee, Craig M., Lelong, M.-Pascale, Levine, Murray D., Lien, Ren-Chieh, Mahadevan, Amala, McWilliams, James C., Molemaker, M. Jeroen, Mukherjee, Sonaljit, Nash, Jonathan D., Özgökmen, Tamay, Pierce, Stephen D., Ramachandran, Sanjiv, Samelson, Roger M., Sanford, Thomas B., Shearman, R. Kipp, Skyllingstad, Eric D., Smith, K. Shafer, Tandon, Amit, Taylor, John R., Terray, Eugene A., Thomas, Leif N., and Ledwell, James R.
- Abstract:
- Lateral stirring is a basic oceanographic phenomenon affecting the distribution of physical, chemical, and biological fields. Eddy stirring at scales on the order of 100 km (the mesoscale) is fairly well understood and explicitly represented in modern eddy-resolving numerical models of global ocean circulation. The same cannot be said for...
- Resource Type:
- Article
- Full Text:
- M. KlyMAK, crAiG M. lee, M.-PAScAle lelonG, MurrAy d. levine, ren-chieh lien, AMAlA MAhAdevAn
-
- Creator:
- McPhillie, Martin, Zhou, Ying, El Bissati, Kamal, Dubey, Jitender, Lorenzi, Hernan, Capper, Michael, Lukens, Amanda K, Hickman, Mark, Muench, Stephen, Verma, Shiv Kumar, Weber, Christopher R., Wheeler, Kelsey, Gordon, James, Sanders, Justin, Moulton, Hong, Wang, Kai, Kim, Taek-Kyun, He, Yuqing, Santos, Tatiana, Woods, Stuart, Lee, Patty, Donkin, David, Kim, Eric, Fraczek, Laura, Lykins, Joseph, Esaa, Farida, Alibana-Clouser, Fatima, Dovgin, Sarah, Weiss, Louis, Brasseur, Gael, Wirth, Dyann, Kent, Michael, Hood, Leroy, Meunieur, Brigitte, Roberts, Craig W., Hasnain, S. Samar, Antonyuk, Svetlana V., Fishwick, Colin, and McLeod, Rima
- Abstract:
- Toxoplasma gondii, the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, and is currently incurable. New, curative medicines are needed urgently. Herein, we develop novel models to facilitate drug development: EGS strain T. gondii forms cysts in vitro that induce oocysts in...
- Full Text:
- Kim 10 , Yuqing He 10 , Tatiana Santos 11 , Stuart Woods 12 , Patty Lee 8 , David Donkin 8
-
- Creator:
- McPhillie, Martin, Zhou, Ying, El Bissati, Kamal, Dubey, Jitender, Lorenzi, Hernan, Capper, Michael, Lukens, Amanda K, Hickman, Mark, Muench, Stephen, Verma, Shiv Kumar, Weber, Christopher R., Wheeler, Kelsey, Gordon, James, Sanders, Justin, Moulton, Hong, Wang, Kai, Kim, Taek-Kyun, He, Yuqing, Santos, Tatiana, Woods, Stuart, Lee, Patty, Donkin, David, Kim, Eric, Fraczek, Laura, Lykins, Joseph, Esaa, Farida, Alibana-Clouser, Fatima, Dovgin, Sarah, Weiss, Louis, Brasseur, Gael, Wirth, Dyann, Kent, Michael, Hood, Leroy, Meunieur, Brigitte, Roberts, Craig W., Hasnain, S. Samar, Antonyuk, Svetlana V., Fishwick, Colin, and McLeod, Rima
- Abstract:
- Toxoplasma gondii, the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, and is currently incurable. New, curative medicines are needed urgently. Herein, we develop novel models to facilitate drug development: EGS strain T. gondii forms cysts in vitro that induce oocysts in...
- Full Text:
- Kim 10 , Yuqing He 10 , Tatiana Santos 11 , Stuart Woods 12 , Patty Lee 8 , David Donkin 8
-
- Creator:
- McPhillie, Martin, Zhou, Ying, El Bissati, Kamal, Dubey, Jitender, Lorenzi, Hernan, Capper, Michael, Lukens, Amanda K, Hickman, Mark, Muench, Stephen, Verma, Shiv Kumar, Weber, Christopher R., Wheeler, Kelsey, Gordon, James, Sanders, Justin, Moulton, Hong, Wang, Kai, Kim, Taek-Kyun, He, Yuqing, Santos, Tatiana, Woods, Stuart, Lee, Patty, Donkin, David, Kim, Eric, Fraczek, Laura, Lykins, Joseph, Esaa, Farida, Alibana-Clouser, Fatima, Dovgin, Sarah, Weiss, Louis, Brasseur, Gael, Wirth, Dyann, Kent, Michael, Hood, Leroy, Meunieur, Brigitte, Roberts, Craig W., Hasnain, S. Samar, Antonyuk, Svetlana V., Fishwick, Colin, and McLeod, Rima
- Abstract:
- Toxoplasma gondii, the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, and is currently incurable. New, curative medicines are needed urgently. Herein, we develop novel models to facilitate drug development: EGS strain T. gondii forms cysts in vitro that induce oocysts in...
-
- Creator:
- Jordan, Tuajuanda C., Burnett, Sandra H., Carson, Susan, Caruso, Steven M., Clase, Kari, DeJong, Randall J., Dennehy, John J., Denver, Dee R., Dunbar, David, Elgin, Sarah C. R., Findley, Ann M., Gissendanner, Chris R., Golebiewska, Urszula P., Guild, Nancy, Hartzog, Grant A., Grillo, Wendy H., Hollowell, Gail P., Hughes, Lee E., Johnson, Allison, King, Rodney A., Lewis, Lynn O., Li, Wei, Rosenzweig, Frank, Rubin, Michael R., Saha, Margaret S., Sandoz, James, Shaffer, Christopher D., Taylor, Barbara, Temple, Louise, Vazquez, Edwin, Ware, Vassie C., Barker, Lucia P., Bradley, Kevin W., Jacobs-Sera, Deborah, Pope, Welkin H., Russell, Daniel A., Cresawn, Steven G., Lopatto, David, Bailey, Cheryl P., and Hatfull, Graham F.
- Abstract:
- Engaging large numbers of undergraduates in authentic scientific discovery is desirable but difficult to achieve. We have developed a general model in which faculty and teaching assistants from diverse academic institutions are trained to teach a research course for first-year undergraduate students focused on bacteriophage discovery and genomics. The course...
- Full Text:
- Gail P. Hollowell,p Lee E. Hughes,q Allison Johnson,r Rodney A. King,s Lynn O. Lewis,t Wei Li,u Frank
-
- Creator:
- Jordan, Tuajuanda C., Burnett, Sandra H., Carson, Susan, Caruso, Steven M., Clase, Kari, DeJong, Randall J., Dennehy, John J., Denver, Dee R., Dunbar, David, Elgin, Sarah C. R., Findley, Ann M., Gissendanner, Chris R., Golebiewska, Urszula P., Guild, Nancy, Hartzog, Grant A., Grillo, Wendy H., Hollowell, Gail P., Hughes, Lee E., Johnson, Allison, King, Rodney A., Lewis, Lynn O., Li, Wei, Rosenzweig, Frank, Rubin, Michael R., Saha, Margaret S., Sandoz, James, Shaffer, Christopher D., Taylor, Barbara, Temple, Louise, Vazquez, Edwin, Ware, Vassie C., Barker, Lucia P., Bradley, Kevin W., Jacobs-Sera, Deborah, Pope, Welkin H., Russell, Daniel A., Cresawn, Steven G., Lopatto, David, Bailey, Cheryl P., and Hatfull, Graham F.
- Abstract:
- Engaging large numbers of undergraduates in authentic scientific discovery is desirable but difficult to achieve. We have developed a general model in which faculty and teaching assistants from diverse academic institutions are trained to teach a research course for first-year undergraduate students focused on bacteriophage discovery and genomics. The course...