RAS and Rho small GTPases are key molecular switches that control cell dynamics, cell
growth and tissue development through their distinct signaling pathways. While much has been
learnt about their individual functions in both cell and animal models, the physiological and
pathophysiological consequences of their signaling crosstalk in multi-cellular context...
Full Text:
. Spitsbergen
4
, Zhiyuan Gong
3
, BoonChuanLow
1,2*
1
Cell Signaling and Developmental Biology
RAS and Rho small GTPases are key molecular switches that control cell dynamics, cell
growth and tissue development through their distinct signaling pathways. While much has been
learnt about their individual functions in both cell and animal models, the physiological and
pathophysiological consequences of their signaling crosstalk in multi-cellular context...
RAS and Rho small GTPases are key molecular switches that control cell dynamics, cell
growth and tissue development through their distinct signaling pathways. While much has been
learnt about their individual functions in both cell and animal models, the physiological and
pathophysiological consequences of their signaling crosstalk in multi-cellular context...
RAS and Rho small GTPases are key molecular switches that control cell dynamics, cell
growth and tissue development through their distinct signaling pathways. While much has been
learnt about their individual functions in both cell and animal models, the physiological and
pathophysiological consequences of their signaling crosstalk in multi-cellular context...
RAS and Rho small GTPases are key molecular switches that control cell dynamics, cell
growth and tissue development through their distinct signaling pathways. While much has been
learnt about their individual functions in both cell and animal models, the physiological and
pathophysiological consequences of their signaling crosstalk in multi-cellular context...
RAS and Rho small GTPases are key molecular switches that control cell dynamics, cell
growth and tissue development through their distinct signaling pathways. While much has been
learnt about their individual functions in both cell and animal models, the physiological and
pathophysiological consequences of their signaling crosstalk in multi-cellular context...
RAS and Rho small GTPases are key molecular switches that control cell dynamics, cell
growth and tissue development through their distinct signaling pathways. While much has been
learnt about their individual functions in both cell and animal models, the physiological and
pathophysiological consequences of their signaling crosstalk in multi-cellular context...
RAS and Rho small GTPases are key molecular switches that control cell dynamics, cell
growth and tissue development through their distinct signaling pathways. While much has been
learnt about their individual functions in both cell and animal models, the physiological and
pathophysiological consequences of their signaling crosstalk in multi-cellular context...
RAS and Rho small GTPases are key molecular switches that control cell dynamics, cell
growth and tissue development through their distinct signaling pathways. While much has been
learnt about their individual functions in both cell and animal models, the physiological and
pathophysiological consequences of their signaling crosstalk in multi-cellular context...
Infrastructures along the Oregon Coast are vulnerable to seismic events in the Cascadia Subduction Zone that could generate large tsunamis. Bridges along the coast are an important part of the transportation and lifeline system in the area. The major damages on these bridges due to earthquake and/or tsunami would result...
This research was designed to study the perinatal and
postweaning effects of the interaction between ethanol and low
dietary zinc during gestation and lactation in the rat.
Pregnant rats were fed liquid diets containing either 2 or 10
μg zinc/ml with or without 30% of kcal from ethanol throughout
gestation...
Wave runup is an important physical process that affects nearshore sediment transport, coastal erosion, and flooding. Large and unexpected runup events can also be dangerous to beach goers. Extreme runup statistics are essential parameters used in engineering design of marine structures and in coastal management. Although the study of runup...
Skeletal muscle proteins are the largest amino acid pool in animal body and are continuously degraded and resynthesized. Dozens of factors have been shown to influence the balance between synthesis and degradation and thereby regulate muscle growth and function. It is now know that one of the major regulatory bases...
The interactions between microbial taxa have been under great research interest in the sci- ence community given the microbiome data deluge. Several methods have been proposed to model and estimate the conditional dependency between microbial taxa for their interac- tions, in order to eliminate spurious correlation detections. However, these methods...
Recombinant human calpain-5 was expressed in insect cells using a baculovirus system. The expressed calpain-5 was purified by both traditional chromatography and by affinity-column chromatography. Both methods yielded active protease. Calpain-5 displayed very limited hydrophobicity. This indicated that calpain-5 is not a membrane binding protein. Calpain-5 had pI of 8.3....
Genetic variability in natural populations of Douglas-fir was
studied at molecular level by investigating the variations of some
primary gene products, i. e. enzymes. Using the techniques of disc
gel electrophoresis and biochemical staining, the isoenzyme patterns
of leucine aminopeptidase, esterase and glutamate oxaloacetate
transaminase are characterized in young seedlings...
This thesis describes the design of a single-chip
logic analyzer. The utility of such a chip in measuring
and recording digital system parameters is illustrated.
Possibilities for future applications of this chip in
performance monitoring of computer systems are discussed.
Atherosclerosis is the underlying cause of ischemic heart disease and stroke and is the leading cause of death worldwide, especially in developed countries. As an inflammatory disease of arteries in a hyperlipidemic milieu, expression of adhesion molecules, such as endothelial-leukocyte adhesion molecule-1 (E-selectin) and intercellular adhesion molecule-1 (ICAM-1), on endothelial...
This thesis addresses the research question: How do different
physical layouts of high-rise college dormitories affect residents'
perceptions of satisfaction and crowding? The purpose of the research
was to outline some design strategies that could be used to provide
designers with information which can help them to design better high...
It is hypothesized that the circulation of the tropical Pacific Ocean and atmosphere satisfies the equations of a simple coupled model to within errors having specified covariances, and that the Tropical Atmosphere–Ocean array (TAO) measures the circulation to within errors also having specified covariances. This hypothesis is tested by finding...
The investigation of the consequences of trying to blend tropical Pacific observations from the Tropical Atmosphere–Ocean (TAO) array into the dynamical framework of an intermediate coupled ocean–atmosphere model is continued. In a previous study it was found that the model dynamics, the prior estimates of uncertainty in the observations, and...
A nonlinear 2½-layer reduced gravity primitive equations (PE) ocean model is used to assimilate sea surface
temperature (SST) data from the Tropical Atmosphere–Ocean (TAO) moored buoys in the tropical Pacific. The
aim of this project is to hindcast cool and warm events of this part of the ocean, on seasonal...
Solar thermal energy can be stored and later converted to electrical energy using a combination of thermochemical energy storage (TCES) and a thermoelectric generator (TEG). This TEG and TCES combination illustrates a potential route for clean electricity storage from renewable energy. TCES allows for thermal energy from the sun to...
Low-power millimeter-wave (mm-wave) transceivers are of interest for achieving energy-efficient high data rate short-reach wireless and guided-wave links.
Spatial modulation or space-shift keying (SSK) can provide energy efficiency improvements by using antenna-switching or transmission direction switching for data modulation. Such links are particularly attractive at millimeter-wave frequencies due to small...
Background: Little is known about the potential of Brachypodium distachyon as a model for low temperature stress
responses in Pooideae. The ice recrystallization inhibition protein (IRIP) genes, fructosyltransferase (FST) genes, and
many C-repeat binding factor (CBF) genes are Pooideae specific and important in low temperature responses. Here
we used comparative...
Myc is a pleiotropic transcription factor that is involved in many cellular activities relevant to carcinogenesis, including hepatocarcinogenesis. The zebrafish has been increasingly used to model human diseases and it is particularly valuable in helping to identify common and conserved molecular mechanisms in vertebrates. Here we generated a liver tumor...
We present field data and data from the literature to highlight the effects of low-tide rainfall on particulate organic carbon (POC) redistribution in intertidal landscapes. The POC exchanges reported from disparate but related studies were standardized to a storm-induced exchange rate (gPOC m⁻² mmRain⁻¹) and compared. Results show that these...
The critical contribution of this dissertation is to provide a better
understanding of the fundamental Chemical Bath Deposition (CBD) growth
kinetic and mechanism for the well known II-VI semiconductor CdS using the
newly developed continuous flow microreactor. This continuous flow microreactor
provides the temporal resolution to control the homogeneous reaction...
Every year, hundreds of low-income families on the Oregon Coast are forced to choose between putting food on the table and paying the bills. A local, non-profit agency on the Oregon Coast is working to alleviate the level of crisis that many families face, by offering a holistic approach to...
Knowledge of the shear stress on a fault during slip is necessary
for a physically-based understanding of earthquakes. Borehole
temperature measurements inside the fault zone immediately after
an earthquake can record the energy dissipated by this stress. In the
first Wenchuan Earthquake Fault Zone Scientific Drilling Project
hole (Sichuan province,...
As the Internet has radically changed modern life, much attention has been paid to the outcomes produced by the diffusion of online access. In the modern economy, reliable Internet access is a crucial tool offering better access to information and opportunities, increasing work efficiency, and facilitating personal connection, leaving those...
This novel-in-progress is an attempt to struggle with the complicated process of forging one’s identity in the murk of urban Northwest life. The protagonist of this piece is confused, to put it lightly: bi-racial, torn between the affections of divorced parents, unsure about his religious views, and baffled by his...
At its inception in 1946, the United States’ National School Lunch Program (NSLP) was promoted as a success story; a boon for families navigating poverty, a means of buoying food prices by absorbing farm surplus, and a treatment for hunger in some of our country’s most vulnerable populations. Government subsidies...
Starting in the 1960's, the demand for recreational properties nationwide experienced a great surge. [Reilly, 1973; David, 1969; Hoover, n.d.; ASPO, 1976]
A number of studies have been done of the impact of recreational subdivisions on local taxes. [Tillson, et. al. 1972; Thompson and Myrick, 1975; LeJeune, 1972; Moss and...
In the study of nutritional variability in potato it is desirable to know the present range of expression and genetic potential for increase. Potato breeding lines and varieties in two separate trials were evaluated for potassium and phosphorus content by wet ashing and Inductively Coupled Argon Plasma Emission Spectrophotometer analysis....
We report an inverse relationship between measurable porosity values and reversible capacity from sucrose-derived hard carbon as an anode for sodium-ion batteries (SIBs). Materials with low measureable pore volumes and surface areas obtained through N₂ sorption yield higher reversible capacities. Conversely, increasing measurable porosity and specific surface area leads to...
In this work we consider a mathematical and computational model for biofilm growth and nutrient utilization. In particular, we are interested in a model appropriate at a scale of interface. The model is a system of two coupled nonlinear diffusion--reaction partial differential equations (PDEs). One of these PDEs is subject...
One of the challenges in oceanography is to understand the influence of environmental factors on the abundances of prokaryotes and viruses. Generally, conventional statistical methods resolve trends well, but more complex relationships are difficult to explore. In such cases, Artificial Neural Networks (ANNs) offer an alternative way for data analysis....
Shrinkage cracks in soil function as a dominant control on the partitioning and distribution of moisture fluxes in the vadose zone. Their dynamics influence moisture balance and control water availability for runoff, deep infiltration, and near-surface storage. We present a new low-cost field instrument to monitor the temporal change in...
Structural Health Monitoring (SHM) is known as the process of implementation of damage detection and characterization strategy. The method is widely used in modern critical equipment to minimize the risk of failures. While a significant effort has been devoted by researchers for the detection of faults in situations including periodic...
Reports on an investigation of a proposed project in Coos Bay to see if native bay clam populations were threatened. "The Coos Bay Pulp Corporation proposes to build a bulkhead and drive piling for log storage facilities in the vicinity of their plant." (p.1). Includes a hand-drawn map of the...
Anammox (anaerobic ammonium oxidation) bacteria are capable of providing low-cost nitrogen removal for numerous types of wastewaters. However, low growth rates cause long startup-times and inhibition by oxygen and metabolic substrates necessitate close process control to maintain performance. Incorporation of Simultaneous Anammox and Denitrification (SAD) into constructed wetlands could provide...
Vacuum ultraviolet absorption spectra of 13 model sugar compounds
were measured in the energy range of 50 to 80 kK. The model
sugars included three simple alcohols, four simple ethers, four cyclic
alcohol-ether compounds, and two dioxanes. All spectra show
transition bands in the energy region 50 to 65 kK....
After 22 years of eruption at Kilauea Volcano, Hawai'i, an environmental, epidemiological, and ethnographic study was conducted to assess for adverse health effects from chronic exposure to volcanogernc air pollution. Environmental data from 2003 indicated that Kau District, from 37 to 74 km downwind from the eruption, was being exposed...
We conducted two experiments evaluating perennial ryegrass straw as a forage source for ruminants. Experiment 1 evaluated digestion and physiological variables in steers offered perennial ryegrass straw containing increasing levels of lolitrem B. Sixteen ruminally cannulated Angus X Hereford steers (231 ± 2 kg BW) were blocked by weight and...
The Internet of Things (IoT) paradigm brought an ever-increasing dependence on low-power devices to collect sensor data and transmit that information to the cloud, placing greater demand on connectivity and lifespan. In response, rapid worldwide innovation demonstrates the trade-offs in processing, communication, and energy consumption with diverse approaches to low-power...
Deep learning is now being utilized widely in applications where sensitive data is being used for model training, for example, in health care. In this scenario, any data leakage will cause privacy concerns to whose data records are used to train the model. An attacker can actively cause privacy leakage...
Wild populations of fish are faced with a multitude of stressors, which may include human interaction, toxins, and disease. Benzo(a)pyrene (BaP), a known carcinogen and immunotoxin, has been reported in the stomach contents of juvenile chinook salmon, Oncorhynchus tshawytscha, in urban waterways. We investigated the impact of chronic dietary exposure...
The Java programming language is a recent entry in the family of object-oriented languages and like all new languages has yet to achieve widespread standardization of coding styles for the unique aspects it possesses. This paper and project address this issue by presenting a complete and rationalized style guide for...
Wind turbines serve an increasing proportion of total energy generation, with expanded onshore and offshore installations proceeding worldwide. Continued construction, expansion, and operation of wind energy installations must be managed in conjunction with effects on local and migratory wildlife, specifically bird and bat species that may be affected by wind...
Specific energy, defined as the energy consumed by per unit volumetric removal rate, is one of the key metrics used for evaluating the environmental performance of a machining process. Grinding is a traditional machining process, characterized by high specific energy and poor environmental performance. Growing global concerns about climate change...
Saccharomyces cerevisiae strain XS-380, a. heteroallelic
diploid strain, carries six genetically analyzed loci on the left arm of
chromosome VII. Nitrosoguanidine (NMG) at low concentrations was
observed to cause allelic recombination (either mitotic recombination
or gene conversion) of the heteroallelic loci with low lethality.
The NMG-inducible heteroallelic system was used...
This research project compared teacher attitude using
the Pupil Control Ideology Form with student attitude using
the Arlin-Hills Student Attitude Survey. P.C.I. Forms
were collected from 834 teachers from 95 elementary Christian
schools in several states. A total of 1074 student
attitude surveys were collected from Christian school students
in...
A benthic microbial fuel cell (BMFC) is an electrochemical device that
generates current from the redox gradient at the sediment-water interface. Early
prototypes had anodes buried in anoxic sediments and cathodes in overlying water.
The BMFCs described in this dissertation are based on a chamber design that enables
the use...
Published June 1936. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Presented in this report is an investigation of the design, construction, and operation of scaled-up cloth electrode assembly (CEA) air-cathode microbial fuel cells (MFCs). 40 mL MFCs were designed and constructed using either single or double CEAs with carbon cloth electrodes. The MFCs were evaluated using acetate media, municipal wastewater,...
The World Health Organization defines food security as “all people at all times have access to sufficient, safe, nutritious food to maintain a healthy and active life.” The reality is that one in six Americans are not food secure, even though the US produces enough food to feed its national...
The Senior Farmers' Market Nutrition Program (SFMNP), piloted in Oregon in 2001, provided $100 worth of vouchers (aka coupons) to low-income seniors to buy fresh local produce from farmers at farmers' markets and roadside stands. Presented in a political ecology framework, this research integrated the perspectives of beneficiaries and their...
The first area of investigation involves the electron transport
of sub-mitochondrial particles and their components. The second
area is the synthesis of ATP and other energy linked reactions and
components of the energy conservation and transfer apparatus.
Investigations on the nature of the tetramethyl-p-phenylenediamine
(TMPD) shunt indicated that tetrachlorohydroquinone (TCHQ)...
Apart from the traditional role of preventing progression from HIV to AIDS, antiretroviral drug therapy (ART) has an additional benefit of substantially reducing infectiousness, making them potentially an important strategy in the fight against HIV. Recent advances in drug therapy have also seen the use of antiretroviral drugs as a...
Biochars have potential value for greenhouse nurseries as a potting amendment, reducing the need for environmentally costly products currently in use. The onsite manufacture of biochars by pyrolysis of woody waste offers additional greenhouse value as a source of clean heat. However, recent work observed that some biochars may evolve...
Forest canopy cover presents a major challenge for remote sensing of fractional snow-covered area (ƒSCA). Snow cover is systematically underestimated where satellites sensors cannot penetrate the forest canopy. Current canopy adjustments scale observable ƒSCA with the vegetation fraction, assuming that snow cover distributions are similar between sub-canopy and open locations....
Improving the coexistence of eagles and wind energy is a critical effort for the sustainable expansion of the wind energy sector. Information about eagle activity and interactions with wind turbines enables verification of deterrence methods. This information can be broken into two categories: eagle activity in the airspace around wind...
Since its introduction in the early 1990s, the quick growth of the World Wide Web
(WWW) traffic raises the question of whether past Local Area Network (LAN) packet
traces still reflect the current situation or whether they have become obsolete. For this
thesis, several LAN packet traces were obtained by...
Published October 1935. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Published March 1938. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Published January 1937. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Published July 1928. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
This research asserts that flood risk perception of individuals living in floodplains influences their preparedness for taking actions to protect themselves from flood hazards. The results of this research are backed up by quantitative analysis of survey responses of individuals living in floodplains of Corvallis, OR in the USA. The...
Lasting, effective solutions to nitrogen (N) loss from container nurseries must
address layers of complexity ranging in scale from whole system nursery management
to gene expression. Group-based On-site Active Learning (GOAL) was developed to
aid nursery managers and related stakeholders (e.g. neighbors, policy makers,
regulating agencies, researchers) in developing a...
Published March 1936. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
This ethnography looks at the processes a rural Oregon community is undergoing as some members attempt to re-animate the community by creating a community center after the loss of its school and market, two vital services that provided venues for social interaction and engagement.
The methodology for this research includes...
Massively multiplayer role-playing games (MMORPG) are becoming a popular leisure activity world-wide. MMORPG players have created a new kind of market, one for virtual possessions. Some players will buy and sell virtual goods for real-world money. Many game developers oppose this real-market trade because it threatens the control of their...
Marine reserves are known to directly replenish overfished species. However, the
community-wide effects of reserves are less clear. I examined the community of coralreef
fishes in a large, fully protected marine reserve in The Bahamas: the Exuma Cays
Land and Sea Park. Visual-transect surveys provided estimates and comparisons of the...
Family influence in the home environment has been linked to children’s nutrition and physical activity behaviors. However few tools exist to identify family level behaviors and families’ readiness to change those behaviors, particularly for populations at high risk for obesity such as Hispanics. This study summarizes the relationships of similar...
Rooted in the writer's general concern with the teaching and
evaluation of writing, this study attempts to determine whether
verbally creative teachers are better able to identify verbally creative
students than are less verbally creative teachers. A second aim was
to determine whether the verbal creativity of the teacher is...
The objectives of this research were to determine the effects of various soil parameters on the reaction of Isopropyl-N-(3-chlorophenyl)Carbamate (CIPC) with a soil and to relate enthalpy values for the adsorption to chemical or physical bonding mechanisms. Six Oregon soils providing a range of pH, organic matter, clay, iron oxide,...
Wood is a key structural element in aquatic ecosystems. Wood provides habitat complexity, alters geomorphology, retains organic and inorganic material, promotes hyporheic flow, and acts as substrate for biofilms and invertebrates. Fire is an important disturbance promoting wood recruitment into inland waters, but most studies have focused on streams in...
Sensory properties of four important volatile sulfur compounds, dimethyl disulfide (DMDS), diethyl disulfide (DEDS), methanethiol (MeSH) and ethanethiol (EtSH), were determined in base Oregon Pinot noir wine in order to understand their impacts on wine aroma. Detection thresholds of these four compounds in base wine were determined first. All four...
Lodgepole pine (Pinus contorta) forests are widely distributed throughout western North America. However, the lodgepole pine forests of central Oregon are ecologically unique to the region, with a mixed severity fire regime, low cone serotiny, and their occasional presence as a climax species. Most of the research conducted regarding the...
An experiment was conducted to determine the best method to
establish subterranean clover on medusahead infested ranges in
Western Oregon. Secondary objectives of this study were to determind
the effects of management treatments on (a) subterranean
clover density, (b) density of medusahead and other vegetation, and
(c) yield of subterranean...
The restoration of rivers and streams should be based on a
strong conceptual framework. Streams are developing systems. As
such, streams exhibit temporal behaviors that change with changing
stream environments. Underlying the dynamic development of streams is
potential capacity. Streams express this capacity as an array of
habitats over time...
The effect of soil water suction and soil temperature on rates
of transpiration, photosynthesis, respiration and nitrogen fixation of
soybean (Glycine max. Merrill, var. Chippewa 64) seedlings was
studied. A special apparatus was developed in which the soil water
suction of several cells with soybeans growing in them could be...
Rising global temperatures are having lasting effects on mountain snow environments in the form of diminishing snowpacks, shorter accumulation seasons, and shifts in meltwater timing. Seasonal snowpack is a vital source of water for natural and human systems. In the forested mountain landscapes of the Pacific Northwest seasonal snowmelt feeds...
In 2011, the Oregon legislature passed the Farm Direct Marketing Law (FDML), which took effect in 2012. The law clarified licensing and food safety requirements for direct-to-consumer sales at farmers markets, farm stands, and similar venues. It also included a "cottage food" provision allowing farms to make and sell certain...
The western United States is experiencing significant changes in wildfire and snow regimes as a result of warming temperatures. An amplification of wildfire activity and reduction in snow water equivalent, snow covered area, and earlier spring snowmelt are documented trends that are projected to continue into the future. With an...
This report reviews the state of the California Current System (CCS) between winter 2012 and spring 2013, and includes observations from Washington State to Baja California. During 2012, large-scale climate modes indicated the CCS remained in a cool, productive phase present since 2007. The upwelling season was delayed north of...
Full Text:
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ucdavis.edu/boon/current_plots.html). Plotted data are
averaged over spatial bins west of Point Reyes: “near
The Oregon wine industry is growing and becoming increasingly valuable to the regional economy. As with many production industries, the wine industry has faced concerns around its environmental practices and community impact. The use of synthetic pesticides, herbicides, fertilizers, and associated wastewater run-off are a few issues vineyard managers experience....
The purpose of this research was to determine if a basic protein
was associated with the DNA of Bacillus subtilis W168, and to determine
if there was a difference in the amount and type of protein
associated with the DNA at different times during the growth cycle
of the organism....
An investigation was conducted to determine the impact of economic and
non-economic factors on the off-farm work efforts of Oregon farm husbands and
wives. A total of 283 Oregon farm households (with husbands and wives) were
randomly selected from lists of persons deferring taxes for farm purposes, obtained
from County...