Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
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of
Thioureas and Thiones
Henderson, M. C., Siddens, L. K., Krueger, S. K., Stevens, J. F., Kedzie
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Mammalian flavin-containing monooxygenase (FMO) is active towards many drugs with a heteroatom having the properties of a soft nucleophile. Thiocarbamides and thiones are S-oxygenated to the sulfenic acid which can either react with glutathione and initiate a redox-cycle or be oxygenated a second time to the unstable sulfinic acid. In...
Diet History Questionnaires (DHQ) can only provide general information about a person’s nutritional intake. It is unable to cluster groups of people based on diets or lifestyles, nor identify specific foods that may play a role in disease prevention. The aim of this study was to validate the use of...
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polyphenols can lower certain diseases.
Acknowledgements
Special thanks to FredStevens, Jaewoo Choi, Sandra
Nanotechnology is of increasing significance. Curation of nanomaterial data into electronic databases offers opportunities to better understand and predict nanomaterials’ behaviour. This supports innovation in, and regulation of, nanotechnology. It is commonly understood that curated data need to be sufficiently complete and of sufficient quality to serve their intended purpose....
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Lynch,b Willie Peijnenburg,c,d John Rumble,e
Fred Klaessig,f Clarissa Marquardt,g Hubert Rauscher,h
The western spotted cucumber beetle (Diabrotica undecimpunctata
undecimpunctata) and the western striped cucumber beetle (Acalymma trivittatum) are
pests of many crops, including vegetable, fruit, and nursery crops. Pesticides are
commonly used to control this pest. Trap and kill technologies are under development as
use in an alternative control for cucumber...
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trap designs on beetle capture rate.
Cucurbitacin E glycoside
Isolation
FredStevens
lab.
BHM
Metabolic syndrome, characterized by a collection of risk factors including abdominal obesity, insulin insensitivity, elevated plasma triglycerides, hypertension and low plasma high-density lipoproteins (HDLs), is a major contributing factor to the development of cardiovascular diseases and type II diabetes (T2D). Xanthohumol (XN), a flavonoid isolated from Humulus lupulus cones, has...
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repeated using C57BL/6J female mice
Acknowledgements
FredStevens
Jaewoo Choi
Ralph Reed
Val Miranda
Small molecule metabolomics is a promising new field in medicine. Studying the chemical effects of individual cellular processes is a powerful approach in determining physiological impacts of various factors such as age, cancer stage, and genetic variability at a cellular level. However, the reactive nature and small size of many...
Small molecule metabolomics is a promising new field in medicine. Studying the chemical effects of individual cellular processes is a powerful approach in determining physiological impacts of various factors such as age, cancer stage, and genetic variability at a cellular level. However, the reactive nature and small size of many...
Obesity is achieved at the point where fat accumulation begins to exert deleterious effects on an organism. The human body accrues fat when there is an energy imbalance occurring, where caloric intake exceeds expenditure.Many anti-obesity drugs used in the past have had undesirable side effects, and currently there is a...
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Food Res, 52(1), 7-25.
In 2008, Dr.’s FredStevens and Claudia Maier put out a paper stating that
The post-translational modification of proteins by electrophilic oxylipids is emerging as an important mechanism that contributes to the complexity of proteomes. Enzymatic and non-enzymatic oxidation of biological lipids results in the formation of chemically diverse electrophilic carbonyl compounds, such as 2-alkenals and 4-hydroxy alkenals, epoxides and eicosanoids with reactive cyclopentenone...
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; Stevens, et al., 2007). For instance,
CID-MS/MS spectra of peptide-HNE adducts often indicate the
The Santa Barbara-Montecito and Goleta basins are structurally
continuous fault-controlled Pleistocene basins containing
up to 3000 feet (925 m) of marine Pleistocene Santa Barbara Formation
which were deposited on previously deformed Sisquoc and older
strata. Structures subcropping against the unconformity at the
base of the Santa Barbara Formation show that...
The western spotted cucumber beetle (Diabrotica undecimpunctata
undecimpunctata) and the western striped cucumber beetle (Acalymma trivittatum) are
pests of many crops, including vegetable, fruit, and nursery crops. Pesticides are
commonly used to control this pest. Trap and kill technologies are under development as
use in an alternative control for cucumber...
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olfactometry runs
and to temperature-controlled chambers. I would like to thank Dr. FredStevens, from the
The Seaman Gulch area is located approximately 20
miles east of Redding, California and is part of the
eastern Klamath lithotectonic belt.
Rock units of the area are chiefly mafic and silicic
volcanics of island arc affinity and shale that are Permian
to Triassic in age. Volcanic rocks of Tertiary...
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), Nelson (1986),
Miller and Wright (1987), Eastoe and others (1987), and
Stevens and others (1987).
5
The oldest strata present in the Swales Mountain area
are part of the Roberts Mountains allochthon. These include
the western-facies Ordovician Vinini Formation and unnamed
transitional-facies Devonian limestones. The Vinini Formation
comprises dark cherts and black to brown shales
deposited in a deep-water oceanic environment. The Devonian
limestones include numerous...
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exposed at Camp Creek. His earlier studies with
J. Fred Smith in the Pinyon Range, to the south, had
Background: High birthweight is an established risk factor for childhood leukaemia.
Its association with other childhood cancers is less clear, with studies hampered by low
case numbers. Methods: We used two large independent datasets to explore risk associations between
birthweight and all subtypes of childhood cancer. Data for 16 554...
There is no doubt that adhesive penetration plays an important role in wood bondline joint performance and durability; yet, to date there is no direct experimental evidence linking penetration depth with bond performance. This is, in part, because adhesive penetration is commonly assessed with various 2D microscopy techniques that are...
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ACKNOWLEDGEMENTS
I wish to express my sincere gratitude to my major advisor, Dr. Fred Kamke, for his
support
The Greenhorn Mountains contain a tectonic ally disrupted
ophiolite and both arc-derived and pelagic sediments. Age of major
sedimentary units within and bordering the thesis area is Early
Permian, based upon dates of conodonts and fusulinids from contemporaneous
but allocthanous limestones. Sediments near the south
boundary of the thesis area...
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with Dr. A. E. Engel, Dr. J. R. Curray,
Dr. Miriam Kastner, and Dr. Fred Phleger contributed
Clastic sedimentary rocks of the Nanaimo Group on Saltspring Island, British Columbia are Late Cretaceous in age, overlie a deformed and intruded Paleozoic basement complex, and consist of
eight formations. These eight formations, from oldest to youngest, are the Comox, Haslam, Extension-Protection, Cedar District, De Courcy, Northumberland, Geoffrey, and Spray...
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Saltspring Island,
expecially the John Lee family and Mr. Fred Hollings, who were
hospitable and helpful
Provides information about complexity of watersheds. Outlines ways to form partnerships, to develop strategies for enhancing watershed resources, and to implement enhancement projects.