Ceratonova shasta is an obligate endoparasite of salmonid fish that is endemic to the Pacific Northwest of North America. The parasite has a complicated lifecycle with two distinct spore stages and two obligate hosts, a salmonid and a freshwater annelid. Myxospores released from infected salmonid hosts, infect Manayunkia occidentalis (freshwater...
Poor aqueous solubility of a large number of newly discovered chemical entities is posing a significant challenge for the formulation industry and is delaying their drug development. The number of formulation techniques available to solubilize these poorly soluble molecules is very limited. In addition to that, traditional formulation methods involve...
The use of ethionamide has been increasing in drug regiments due to greater incidence of multidrug resistance tuberculosis around the world. Ethionamide is metabolized into antimicrobial relevant compounds by different flavin-containing monooxygenase (FMO) enzymes including FMO1, FMO2, and FMO3. FMOs are found in various locations in the body including the...
Defining the inelastic behavior of nail joints is essential
in the development of a rational design procedure of wood-stud walls.
Prediction equations were developed for the inelastic behavior
of joints commonly found in wood-stud walls. The equations relate
three elastic moduli that define the average inelastic joint stiffness
to the...
Reported here is an investigation to determine the in vitro and in vivo metabolism
of xanthohumol (XN). XN is the major prenylated flavonoid of the female
inflorescences (cones) of the hop plant (Humulus lupulus). It is also a constituent of
beer, the major dietary source of prenylated flavonoids. Recent studies...
Nearly 80% of solid tumors, such as melanoma, metastasize via the lymphatic system. The most common form of melanoma is BRAF-mutant melanoma, and additional mutations, such as a PTEN mutation in the PI3K pathway, is required for metastases to occur. Standard therapy includes treatment with small molecules dabrafenib (DAB) and...
This dissertation presents a research series demonstrating the use of pharmacokinetic modeling and simulations as tools to assess drug concentration and disposition in patient populations. For drugs requiring therapeutic drug monitoring, these tools are necessary to ensure patients are receiving a safe and effective dose of medication to address their...
The assessment of optimum nitrogen (N) fertilizer need for winter wheat (Triticum
aestivum L.) is important for economic and environmental sustainability. A comprehensive understanding of fertilizer N requirement depends on estimation of the quantity of N needed by the crop versus that supplied by soil.
The objectives of this study...
In a series of greenhouse experiments, isolates representing serotypically
distinct subpopulations of Rhizobium leguminosarum bv. trifolii recovered from root
nodules of field-grown subclover Trifolium subterraneum cv. "Nangeela"), were
evaluated for their symbiotic effectiveness potential, their effect on regrowth
potential of subclover, and for their competitive abilities to form nodules. Isolates...
During the course of ripening, Cheddar cheese frequently develops
a flavor defect described as fruity. Recent work has indicated
that the use of certain starter cultures ultimately results in the
development of the defect as the cheese ages. The flavor compounds
responsible for the defect, however, have not been elaborated....
This research focuses on the relationship between the emerging role of land trusts and
rapid growth and change in the West. Teton County, Idaho, Teton County, Wyoming, and
Sublette County, Wyoming, and each of their associated land trusts, are used as case studies. Each county has experienced varying levels of...
Despite advances in treatment, cancer remains among the leading causes of death in the world. Progress in the treatment of metastatic cancers was seen with chemotherapy and radiotherapy, however, the major drawbacks of conventional cancer therapies are limited efficacy and severe side effects. Magnetic fluid hyperthermia (MFH) is a new...
Numerous studies have explored how alluvial channel size and morphology are adjusted to different sediment and flow conditions, yet we still know very little about how and to what degree the flow regime controls channel form and processes. We use the term ‘channel form’ to refer to the size and...
This thesis details my investigation of some pharmaceuticals and natural products on the transport of drugs which are substrates of P-glycoprotein (P-gp), such as cyclosporin A (CSA) and digoxin by using Caco-2 and MDCKII-MDR1 drug transport models. Three objectives were performed to address this goal. The first objective was to...
Cancer is one of the leading causes of death in the U.S., and new approaches to control cancer are constantly sought. This dissertation is comprised of two parts: (i) improving the uptake and retention of gadolinium in tumors for potential gadoliniumneutron capture therapy (Gd-NCT) and (ii) integration of gemcitabine or...
This paper describes the design and implementation of
"A multiprocessor node for communication and control"
(MPCC). MPCC is a high speed, high performance local area
network capable of performing real time control tasks. This
is achieved by the concurrent operation of two 8051
microcontrollers, a dual port RAM and the...
A transient code (TFETC) for calculating the temperature
distribution throughout the radial and axial positions of a
thermionic fuel element (TFE) has been successfully developed.
It accommodates the variations of temperatures, thermal power,
electrical power, voltage, and current density throughout the
TFE as a function of time as well as...
Transparent conductive oxides (TCOs), primarily indium doped tin oxide, have been widely used in numerous fields since decades ago, such as solar cells, displays, OLEDs and ‘smart windows’ etc. Owing to the scarcity of indium, there is a great demand for new alternative materials. Metal/insulator/metal (MIM) diodes are a critical...