The utility of high-throughput, computational screening has become an invaluable asset to the field of materials science. In the hierarchy of computational methods, the most accurate methods are often the most computationally expensive. However, as both the efficiency and fidelity of numerical techniques advance, high-quality screening of large materials datasets...
Healthcare access exhibits differing levels of complexity, often requiring multi-disciplinary approaches to study its barriers and enablers. Though Argentina has achieved nominal universal healthcare coverage through its public healthcare system, full effective coverage has not been achieved. The public system also has a parallel private care system, adding further complexity...
Over the last two centuries, Pilsner beer has become a symbol of Czech national identity. Originating in the Western Czech town of Plzeň, the unique color and flavor spread globally, with new styles further branching off the Central European stem. It is with great pride that the Czech people are...
Quick and accurate measurements of nanoparticles have important applications in biology, environmental and non-proliferation areas. Calculation of isotopic ratios, particularly in special nuclear materials, has relied on integration of nanoparticle counts and limited the capability of counting minor isotopes. Rapid transient detection method of nanoparticles has demonstrated the effectiveness of...
The focus of this thesis is to design, characterize, and apply novel computational methods and molecular systems to interrogate heterogeneous human gut microbiome-related phenomena. In Chapter 2, I design, implement, and characterize a method for embedding co-occurrence patterns derived from massive 16s amplicon datasets. I use this method to 1....
Mosses (Phylum Bryophyta) are widely considered to be among the most ancient groups of land plants (embryophytes) and they are the second most speciose embryophyte phylum with ~13,000 extant species. Despite their diversity and antiquity, mosses have a limited fossil record, which primarily consists of gametophytes entombed in Cenozoic amber....
Given the many significant roles that bacteria play in modern food manufacturing, it is crucial that we have a fundamental understanding of how bacterial communities assemble and behave in the food manufacturing environment. The focus of this dissertation was to investigate both the spatial and temporal distributions of microbial communities...
Photoactivated biomedical tools like fluorescent biosensors and optogenetic proteins have increased in popularity due to the precision targeting and activation used for in vivo applications. In nature, the initially discovered parent proteins exhibit properties such as fluorescence quantum yield (FQY), fluorescence color, and photoswitching dynamics that are unfavorable in mammalian...
Brewers' spent grain (BSG), the byproduct from beermaking, is a good source of protein and dietary fiber and may be utilized as a functional ingredient for food applications such as bakery goods. Starch-based film is well-known for its safety, edibility, and renewability. Starch films with the incorporation of cellulose nanofiber...
Popular botanical dietary supplements marketed for management of menopausal symptoms, including hops (Humulus lupulus L.), red clover (Trifolium pratense) and licorice (Glycyrrhiza uralensis), were evaluated for their potential to alter CYP-mediated drug metabolism clinically and pre-clinically. Both hops and red clover had been reported to inhibit certain cytochrome P450 (CYP)...
With rising sea levels and more frequent exposure to extreme storms, coastlines worldwide are vulnerable to increased erosion and loss of natural marsh lands. In an effort to lessen these impacts, there is a growing practice of adapting hard or “gray” coastline protection techniques to more nature-based features that promote...
Diversity literary awards and other sources were used to create a list of high-quality titles written by and about underrepresented groups. This list was used to assess the diversity and inclusiveness of the library collections of a land-grant university. Gaps in the collection and acquisition processes were identified and will...
An innovative silver nano-dimple arrays (Ag DAs)-integrated microfluidic device was developed to achieve highly sensitive fluorescence-based nucleic acid detection. The Ag DAs were utilized to produce surface plasmon resonance (SPR) for strong fluorescence enhancement. We systematically investigated the plasmon-enhanced fluorescence by controlling the nanostructure dimension of the Ag DA substrate....
Fungi from the genus Chlorociboria are known for their production of the blue-green quinonic pigment xylindein. Extracted xylindein has been the subject of investigations ranging from fabric dying to use a coloring agent in paint, and shows potential as an organic semiconductor in organic photovoltaics (OPVs) and other technologies. However,...
Environmental scientists, land managers, and policy actors are increasingly presented with high-stakes high-uncertainty problems stemming from human-ecosystem interactions. To help address these problems, scientists frequently use models that produce enormous geospatial and temporal datasets that are constantly modified and often seek input from communities outside their discipline. To assist scientists—as...
Native America tribes and community members throughout Oregon have asserted a strong opposition to the fossil fuel industry’s attempt to expand railways, build pipelines, and construct refineries, holding facilities, and export terminals. Despite the limited presence of fossil fuel infrastructure in the state, however, the industry is actively pursuing permits...
3D volume segmentation is a fundamental process in many scientific and medical applications. Producing accurate segmentations, in an efficient way, is challenging, in part due to low imaging data quality (e.g., noise and low image resolution), and ambiguity in the data that can only be resolved with higher-level knowledge of...
This thesis consists of two major components. The first part is concerned with video object instance segmentation (VOS), which is the task of assigning per-pixel labels perframe of a video sequence to indicate foreground object instance membership, given the first frame ground truth mask. VOS has myriad applications, from video...
A major challenge to the study of the peopling of the Americas is that much of the Bering Land Bridge (Beringia), the geographic area that people migrating from Northeast Asia into North America would presumably have passed through, is now submerged due to sea-level rise since the last glacial maximum....