Mercury exposure is widely common throughout the world, ranging from sources such as dental amalgams, fish and seafood consumption, industrial mining, and medicine. A straightforward, efficient, and affordable protocol to measure urine mercury content would greatly contribute to assessing one’s mercury exposure and in categorizing populations that are more vulnerable...
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Dr. AdrianGombart
Mercury exposure is widely common throughout the world, ranging from sources
Antimicrobial peptides (AMPs) play an important role in the innate immune system. Determining the pathways by which these proteins are regulated allows for modulation of their expression for better health. Two families of antimicrobial peptides have been studied in humans: cathelicidins and defensins. There is a single cathelicidin in humans...
In this study, the gene expression levels between 6 month old mice and 26 month
old mice were compared. The purpose of this research was to identify genes that are
differentially regulated due to aging. The results showed 148 significantly differentiated
genes in the analysis of a total of 44,170...
The gut microbiome influences human disease including Type 2 diabetes, obesity and metabolic syndrome and interacts with the innate immune system. The human cathelicidin antimicrobial peptide (hCAMP), an important component of the innate immune system, and vitamin D and xanthohumol, a natural compound found in beer hops, regulate its expression....
Human cathelicidin antimicrobial peptide (CAMP/LL-37) is a cationic antimicrobial peptide that is widely expressed by myeloid and epithelial cells at the human-environment interface. It possesses broad spectrum antimicrobial capacity against bacteria, fungi and viruses. In addition to its direct antimicrobial activity, CAMP/LL-37 also attracts and recruits monocytes, neutrophils and other...
The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) through activation of the vitamin D receptor (VDR) and primary bile salts through activation of the xenobiotic nuclear receptor farnesoid X...
Obesity and metabolic syndrome (MetS) affect over 1.9 billion adults and 12.7 million youth in the US. If all of today’s obese American youth become obese adults, the total societal costs over their lifetime may exceed $1.1 trillion. We show that feeding rodents a high-fat diet supplemented with xanthohumol (XN)...
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AdrianF. Gombart
Obesity and metabolic syndrome (MetS) affect over 1.9 billion adults and
Xanthohumol, a prenylated flavonoid found in hops and beer, possesses a long-standing reputation to improve health. Xanthohumol’s cytotoxicity to a wide variety of cancer cell lines is well-established. Herein we provide further insight into the cytotoxicity of not only xanthohumol, but also its non-estrogenic derivatives, to a number of colonic...
Baculoviruses comprise a diverse group of pathogens
infectious for members of the insect orders Lepidoptera, Hymenoptera
and Diptera. Of the three subgroups, two (subgroup A, nuclear
polyhedrosis virus (NPV) and subgroup B, granulosis virus (GV) are
occluded in a crystalline protein structure while the remaining
subgroup (subgroup C, non-occluded virus)...
In this study, the gene expression levels between 6 month old mice and 26 month
old mice were compared. The purpose of this research was to identify genes that are
differentially regulated due to aging. The results showed 148 significantly differentiated
genes in the analysis of a total of 44,170...
Full Text:
F.
Gombart,
Ph.D.
HHMI
Summer
2012
Oregon
State
University
In this study, the gene expression levels between 6 month old mice and 26 month
old mice were compared. The purpose of this research was to identify genes that are
differentially regulated due to aging. The results showed 148 significantly differentiated
genes in the analysis of a total of 44,170...
Full Text:
Gene Expression Related to the Decline of the Aging Immune System
Jenny Tran and AdrianF. Gombart
Vitamin E (vitE) is a group of lipid-soluble antioxidants- of which alpha-tocopherol is the most biologically active and only form considered to be an essential nutrient. Through preferential binding and trafficking, the alpha-tocopherol transfer protein (α-TTP) regulates the concentration of vitE in the body. The impact of vitE deficiency on...
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AdrianGombart, Committee Member, representing Department of Biochemistry and Biophysics
Brewers' spent grain (BSG), the byproduct from beermaking, is a good source of protein and dietary fiber and may be utilized as a functional ingredient for food applications such as bakery goods. Starch-based film is well-known for its safety, edibility, and renewability. Starch films with the incorporation of cellulose nanofiber...
Nitric oxide (NO) is a signaling molecule that regulates blood pressure and vascular tone. Humans produce NO by endothelial nitric oxide synthase (eNOS), which is impaired in patients with cardiovascular disease leading to increased blood pressure, endothelial dysfunction, and an increased risk of adverse cardiovascular outcomes. Maintaining optimal levels of...
Background: Antimicrobial peptides (AMPs) are synthesized and secreted by immune and epithelial cells that are constantly exposed to environmental microbes. AMPs are essential for barrier defense and deficiencies lead to increased susceptibility to infection. In addition to their ability to disrupt the integrity of bacterial, viral and fungal membranes, AMPs...
Full Text:
, AdrianF. Gombart
1,2
1
Linus Pauling Institute,
2
Department of Biochemistry and Biophysics, Oregon
This work sought to characterize a link between Vitamin C and nitroglycerin at the level of enzymatic bioactivation. Before we could proceed, we needed to develop a method that sensitively and selectively identified the product of bioactivation, nitrite. We successfully adapted traditional diaminonaphthalene derivatization with the use of stable isotope...
Background: Antimicrobial peptides (AMPs) are synthesized and secreted by immune and epithelial cells that are constantly exposed to environmental microbes. AMPs are essential for barrier defense and deficiencies lead to increased susceptibility to infection. In addition to their ability to disrupt the integrity of bacterial, viral and fungal membranes, AMPs...
Background: Antimicrobial peptides (AMPs) are synthesized and secreted by immune and epithelial cells that are constantly exposed to environmental microbes. AMPs are essential for barrier defense and deficiencies lead to increased susceptibility to infection. In addition to their ability to disrupt the integrity of bacterial, viral and fungal membranes, AMPs...
Lactic Acid Bacteria (LAB), an important group of organisms in modern food production, are known to secrete a unique compound called exopolysaccharide (EPS). EPS is economically important because it enhances functional properties in food and may confer beneficial health effects to consumers. Novel strains of Lactococcus lactis, Streptococcus thermophilus, and...
Bcl11b (B-cell lymphoma/leukemia 11b), also known as Ctip2 (Chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2), is a C2H2 zinc finger transcriptional regulatory protein, which is an essential protein for post-natal life in the mouse and plays crucial roles in the development, and presumably function, of several organ systems,...