Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
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Manner in mdx Mice
Limin Cao1,2, Gang Han1, Caorui Lin1, Ben Gu1, Xianjun Gao1, Hong M Moulton3, Yiqi
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
The field performance of genetic containment technologies–considered important for
certain uses of transgenic trees in forestry–are poorly known. We tested the efficiency of a
barnase gene driven by the TA29 tapetum-dominant promoter for influencing growth rate and
inducing male-sterility in a field trial of transgenic hybrid poplar (Populus tremula x...
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. In Phytochemicals, Plant Growth, and the Environment, D.R.
Gang, ed. (Springer New York), pp. 59–78
We report the first systems biology investigation of regulators controlling arterial plaque macrophage transcriptional
changes in response to lipid lowering in vivo in two distinct mouse models of atherosclerosis regression. Transcriptome
measurements from plaque macrophages from the Reversa mouse were integrated with measurements from an aortic
transplant-based mouse model of...