If P is an integer polynomial denote the degree of P by ∂(P) and let H(P) be the maximum of the absolute value of the coefficients of P. Define Λ(P)=2[superscript ∂(P)]H(P) and for a fixed prime p let C[subscript p] denote the completion of the algebraic closure of the p-adic...
Aquatic animals are exposed to a variety of natural and
anthropogenic xenobiotics. Biotransformation of xenobiotics was
examined in three aquatic animals: a primitive mollusc (chiton);
a shellfish which is an important human food source (oyster);
and, a lower vertebrate model for toxicological studies (rainbow
trout). Since digestive glands of Cryntochiton...
This thesis details my investigation of some pharmaceuticals and natural products on the transport of drugs which are substrates of P-glycoprotein (P-gp), such as cyclosporin A (CSA) and digoxin by using Caco-2 and MDCKII-MDR1 drug transport models. Three objectives were performed to address this goal. The first objective was to...
Thermal decomposition of several di-p-toluenesulfonylhydrazones
was studied. It was found that the carbene decomposition
of tetramethyl-1,3-cyclobutanedione, di-p-toluenesulfonylhydrazone
gave two products resulting from
rearrangement. One was identified as 2,5-dimethyl-1,3,4-hexatriene. A tentative structure for the second was
proposed. During the course of the study, a more convenient
procedure for thermal decompositions was...
This thesis describes a Mossbauer effect and electron
paramagnetic resonance study of iron (III) tetraphenylporphyrinatobenzenethiolate
benzene thiol, an analog compound
for bacterial cytochrome P-450. The compound is unusual in
that it provides a model for the two ferric reaction states
of cytochrome P-450. The iron in the model compound exhibits...
Five species of aquatic organisms were exposed to TCDD. Lethal effects of initial exposure to coho salmon of 23.4 nanogram TCDD/gram fish wet weight (23.4 ng/g), or equivalent to 100 nanogram
per liter (100 ng/l) TCDD in water, for 24 hours were irreversible; 95% mortality occurred in 60 days. Exposure...
Signals from the R/V Langseth’s tuned airgun array were recorded on an array of 33 EarthScope FlexArray seismometers deployed in the Oregon Coast Range from 43.5° to 45°N as part of the 2012 Ridge2Trench experiment to image the structure of the Juan de Fuca plate. This segment of the Juan...
BaCuChF (Ch = S, Se, Te) materials are chalcogen-based transparent conductors with wide optical band gaps (2.9 – 3.5 eV) and a high concentration of free holes (10¹⁸ – 10²⁰ cm⁻³) caused by the presence of copper vacancies. Chalcogen vacancies compensate copper vacancies in these materials, setting the Fermi level...
Two lots of six White Leghorn male chickens were fed diets containing
7.3% linoleic acid and either .075% ethoxyquin (lot 1) or 32.4
mg/kg of added vitamin E (lot II) for 47 weeks both of which were
designated as positive controls. A third group (lot III) containing 30
males received...
In 1967, Doi et al. proposed the hypothesis that 'yellows type
diseases' are caused by mycoplasma. Since then more than 60
yellows diseases have been associated with mycoplasma-like bodies
(MLB) (Maramorosch, 1973). The majority of these associations are
based upon electron microscopic observations of mycoplasma-like
bodies in situ. However, little...
In experimentally exposed mice, the environmental contaminant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) produces significant suppression of adaptive immune responses at low doses. However, the underlying biochemical and cellular mechanisms of TCDD-induced immunotoxicity have remained elusive since the identification of these effects nearly 30 years ago. Antigen-presenting cells (APC) constitute various populations of...