Systems biology is becoming increasingly important for the study of living organisms. It focuses on the mathematical understanding of biological systems. Cells, the basic units of all living creatures, are biological systems of major interest. Considerable work is being done towards modeling cells as mathematical systems. At the same time,...
Successive-approximation-register (SAR) analog-to-digital converters are popular for medium accuracy, medium speed and low power applications, such as in biomedical applications. They have low latency and simple architecture compared with ΔΣ ADCs. This is because of SAR ADCs’ binary searching scheme. Furthermore, SAR ADCs can apply oversampling and noise shaping schemes...
In this report, three studies are presented that aid in the development of drug discovery and their synthesis. In each, the importance of the marriage between computations and experiments is highlighted. Continued efforts in this vein are essential for future efforts towards improving human health.
The first case study investigated...
Over the last decade, the use of highly branched macromolecules, called dendrimers, is emerging. Polyamidoamine (PAMAM) dendrimers, in particular, have attracted high interest due to their unique properties, such as well-defined size, shape, and solubility in water. Our group, as part of an interdisciplinary team, is currently working on developing...
The enormous success of wireless technology has recently led to an explosive demand for, and hence a shortage of, bandwidth resources. This expected shortage problem is reported to be primarily due to the inefficient, static nature of current spectrum allocation methods. As an initial step towards solving this shortage problem,...
Various applications like wireless UWB communication, fast data acquisition systems and digital storage oscilloscopes needs ADCs with instantaneous input signal bandwidth from 0.1-40 GigaHertz range with 6-10 bits of resolution -- a challenging task and an impressive goal to achieve. Flash ADCs have been conventionally employed to achieve these goals...
The main objective of the research is to develop a prototype device that can determine the condition of the thermally sprayed zinc anode in cathodic protection systems. The device needs to meet the following requirements: applicability in the field, non-destructiveness or minimal destructiveness of the zinc anode, ease of use...
Metallic glasses (MGs), also called amorphous metals, are metals or metallic alloys trapped in a disordered glassy state. Their amorphous nature and absence of features such as crystal lattices and defects (dislocations, grain boundaries etc.) endows them with a host of properties that far surpass those of common crystalline materials....
Understanding the impact of inter-molecular orientation on the optical proper-ties of organic semiconductors is important for designing next-generation organic (opto)electronic and photonic devices. However, fundamental aspects of how various features of molecular packing in crystalline systems determine the nature and dynamics of excitons have been a subject of debate. Toward...
In the past decades, femtosecond stimulated Raman spectroscopy (FSRS) has been gaining tremendous popularity in fundamental sciences stemming from chemistry to biology. It is capable of capturing both equilibrium and non-equilibrium structural information across a broad range of timescales with simultaneously high temporal and spectral resolutions. Femtosecond transient absorption spectroscopy...
Low carbon steels (LCS) due to their high strength-to-cost ratio are one of the most ubiquitous materials used for a wide range of applications, including but not limited to automotive, construction, and transportation. However, the low corrosion resistance of LCS in neutral, acidic, or saline environments limits its utilization and...
This work introduces the novel flat-histogram Monte Carlo (MC) method stochastic approximation with a dynamic update factor (SAD) and explores the convergence properties of a variety of related weight-based MC methods. The new method is applied to a number of physical `test’ systems including the 2D Ising model, a square-well...
IoT networks can be viewed as collections of Internet-enabled physical devices and objects, embedded with sensor, actuator, computation, storage and communication components, that are capable of connecting and exchanging data to one another. In recent years, organizations have allowed more and more IoT devices to be connected to their networks,...
Mandelalide A has attracted considerable interest from the synthetic community due to its intriguing structure and important cytotoxic activity. Madeirolide A, a structurally related macrolide, shows promising antifungal activity but no appreciable anticancer activity. This dissertation describes synthetic studies toward mandelalide A, madeirolide A and their hybrid structures.
Part I...
To obtain a mechanistic understanding of the chemical processes, techniques that offer a frame-by-frame visualization of molecular structure during a reaction are of vital importance. Numerous efforts and advances have been made in order to acquire such vivid molecular “movies”, especially in the electronic excited state. Ultrafast molecular spectroscopy method...
Femtosecond stimulated Raman spectroscopy (FSRS) is an ultrafast vibrational technique which allows rapid collection of Raman spectra with simultaneously high temporal and spectral resolution. With the recent development of FSRS methodology, three FSRS techniques (conventional, tunable, and anti-Stokes) have been implemented in our laboratory to dissect the excited state structural...
Load modeling that can accurately represent the dynamic behavior of generators and loads is important in the operation and planning of transmission and distribution systems. Yet, it is a complex subject in power system research communities and electric utilities. The composition of the end-use loads is changing continually based on...
Magnetic thin films have potential to improve devices such as on-chip inductors, and enable new technologies such as magnetic random access memory (MRAM).
The use of magnetic cores in on-chip inductors is typically limited to applications well under 1 GHz. At higher frequencies, the performance of the magnetic core is...
The continued development of organic semiconductor materials relies on an understanding of the relationship between optoelectronic properties, molecular structure, and molecular interaction. Several detailed studies of electronic properties in functionalized polyacene materials are presented. A computational model which allows the extraction of charge generation and transport properties from experimental data...
In this thesis, I present a new method we developed to study low frequency (< 700 cm⁻¹) vibrational dynamics: Time-resolved third-harmonic generation (TRTHG) spectroscopy. Among a variety of vibrational spectroscopy techniques, TRTHG differentiates itself with robustness, versatility, and simplicity. In TRTHG experiment, that involves only two ultrashort laser pulses, the...