Background: There is increasing epidemiologic evidence that arsenic exposure in utero, even at low levels found throughout much of the world, is associated with adverse reproductive outcomes and may contribute to long-term health effects. Animal models, in vitro studies, and human cancer data suggest that arsenic may induce epigenetic alterations,...
Effective separation of lanthanides (Ln) from the minor actinides (MA) is a crucial technical challenge to closing the nuclear fuel cycle. This separation is a necessary prerequisite to transmute long-lived isotopes of Am and Cm, which will allow a reduction of the repository volume, thermal load, and radiological toxicity of...
Background: Prenatal mercury (Hg) exposure is associated with adverse child neurobehavioral
outcomes. Because Hg can interfere with placental functioning and cross the placenta to target the
fetal brain, prenatal Hg exposure can inhibit fetal growth and development directly and indirectly.
Objectives: We examined potential associations between prenatal Hg exposure assessed...
Full Text:
Environ Health Perspect
doi: 10.1289/ehp.1408561
Note to Readers: If you need assistance accessing
Partitioning of trivalent actinides (in particular, americium and curium) from the
fission produced light lanthanides is a major concern of used nuclear fuel reprocessing for
the purposes of waste disposal. Several solvent extraction processes have been developed
to address these chemically difficult separations. The historically employed TALSPEAK
Process utilizes di-2-ethylhexyl...
Air pollution epidemiological studies suggest that elevated exposure to fine particulate matter (PM₂.₅) is associated with higher prevalence of term low birth weight (TLBW). Previous studies have generally assumed the exposure–response of PM₂.₅ on TLBW to be the same throughout a large geographical area. Health effects related to PM₂.₅ exposures,...
Background: Few studies examining the associations between long-term exposure to ambient air pollution and mortality have considered multiple pollutants when assessing changes in exposure due to residential mobility during follow-up.
Objective: We investigated associations between cause-specific mortality and ambient concentrations of fine particulate matter (≤ 2.5 μm; PM₂.₅), ozone (O₃),...
Full Text:
Environment Cohort (CanCHEC). Environmental Health Perspectives,
123(11), 1180-1186. doi:10.1289/ehp.1409276
BACKGROUND: Half the world’s population lives in urban areas. It is therefore important to identify
characteristics of the built environment that are beneficial to human health. Urban greenness
has been associated with improvements in a diverse range of health conditions, including birth
outcomes; however, few studies have attempted to distinguish...
Full Text:
Perspectives, 122(10), 1095-1102. doi:10.1289/ehp.1308049
10.1289/ehp.1308049
National Institute of
Background: Prenatal mercury (Hg) exposure is associated with adverse child neurobehavioral outcomes. Because Hg can interfere with placental functioning and cross the placenta to target the fetal brain, prenatal Hg exposure can inhibit fetal growth and development directly and indirectly. Objectives: We examined potential associations between prenatal Hg exposure assessed...
Background: Arsenic is an immunotoxicant. Clinical reports observe the reactivation of varicella zoster virus (VZV) in people who have recovered from arsenic poisoning and in patients with acute promyelocytic leukemia that have been treated with arsenic trioxide. Objective: We evaluated the association between arsenic and the seroprevalence of VZV IgG...
BACKGROUND: Bisphenol A (BPA) is one of the most prevalent chemicals in daily-use materials; therefore, human exposure to BPA is ubiquitous. The estrogenicity of BPA is generally mediated by nuclear estrogen receptors (ERs). However, low concentrations of BPA stimulate seminoma cell proliferation by an uncertain mechanism that does not involve...
BACKGROUND: Half the world’s population lives in urban areas. It is therefore important to identify
characteristics of the built environment that are beneficial to human health. Urban greenness
has been associated with improvements in a diverse range of health conditions, including birth
outcomes; however, few studies have attempted to distinguish...
Full Text:
Environmental Health Perspectives doi:10.1289/ehp.1308049
Supplemental Material
Residential Greenness
Background: Few studies examining the associations between long-term exposure to ambient air pollution and mortality have considered multiple pollutants when assessing changes in exposure due to residential mobility during follow-up.
Objective: We investigated associations between cause-specific mortality and ambient concentrations of fine particulate matter (≤ 2.5 μm; PM₂.₅), ozone (O₃),...
Full Text:
Environment Cohort (CanCHEC)
Environ Health Perspect
DOI: 10.1289/ehp.1409276
Note to Readers: EHP
Background: Prenatal mercury (Hg) exposure is associated with adverse child neurobehavioral
outcomes. Because Hg can interfere with placental functioning and cross the placenta to target the
fetal brain, prenatal Hg exposure can inhibit fetal growth and development directly and indirectly.
Objectives: We examined potential associations between prenatal Hg exposure assessed...
Full Text:
. doi:10.1289/ehp.1408561
10.1289/ehp.1408561
National Institute of Environmental Health Sciences
Exposure to urban outdoor air pollution is ubiquitous and low birth weight represents an important health disparity in the United States. While previous research suggests that exposure to outdoor air pollutants are associated with term low birth weight, few studies have evaluated the effects of multipollutant outdoor air exposures or...
Background: When conducting research with American Indian tribes, informed consent beyond conventional institutional review board (IRB) review is needed because of the potential for adverse consequences at a community or governmental level that are unrecognized by academic researchers. Objectives: In this article, we review sovereignty, research ethics, and data-sharing considerations...
Background: Prenatal mercury (Hg) exposure is associated with adverse child neurobehavioral
outcomes. Because Hg can interfere with placental functioning and cross the placenta to target the
fetal brain, prenatal Hg exposure can inhibit fetal growth and development directly and indirectly.
Objectives: We examined potential associations between prenatal Hg exposure assessed...
Full Text:
: 10.1289/ehp.1408561
Note to Readers: EHP strives to ensure that all journal content is accessible to all
Childhood cancers are rare diseases that affect 188 children in Texas for every million born. Leukemia is the most common childhood cancer and accounts for roughly one third of childhood cancer cases. However, it is estimated that only 10% of childhood cancer cases can be explained by known risk factors....
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Abstract
Perchlorate is a common aquatic contaminant that has long been known to affect thyroid function in vertebrates, including humans. More recently perchlorate has been shown...
Full Text:
. Environ Health Perspect. 2005; 113
(4):396–401. doi: 10.1289/ehp.7333 PMID: 15811828; PubMed Central PMCID
Background:
In the Ganges Delta, chronic arsenic poisoning is a health concern affecting millions of people who rely on groundwater as their potable water source. The prevalence of anemia is also high in this region, particularly among women. Moreover, arsenic is known to affect heme synthesis and erythrocytes and the...
BACKGROUND: Chronic exposure to arsenic is associated with skin lesions. However, it is not known whether reducing arsenic exposure will improve skin lesions.
OBJECTIVE: We evaluated the association between reduced arsenic exposures and skin lesion recovery over time.
METHODS: A follow-up study of 550 individuals was conducted in 2009-2011 on...
BACKGROUND: Arsenic is an epigenetic toxicant and could influence fetal developmental programming.
OBJECTIVES: We evaluated the association between arsenic exposure and DNA methylation in maternal and umbilical cord leukocytes.
METHODS: Drinking-water and urine samples were collected when women were at <= 28 weeks gestation; the samples were analyzed for arsenic...
Wildfires are increasing in frequency. One area of research interest centers on the pollutants within wildfire smoke, including but not limited to particulate matter and polycyclic aromatic hydrocarbons. These chemicals are associated with exacerbation of respiratory, cardiovascular, dermatological, reproductive, oncological, gastrointestinal, and infectious conditions. As wildfires becoming increasingly prevalent, it...
Ubiquitous fine particulate matter (PM2.5) exposures significantly impact global public health, yet little is known about the mechanisms causing these known adverse health effects. Oxidative stress due to PM2.5 associated chemical constituents, such as polycyclic aromatic hydrocarbons (PAHs), is a proposed possible mechanism for PM2.5 mediated health effects. Variations in...
Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants that occur in complex mixtures. These environmental mixtures can consist of both parent PAHs and their derivatives. Several parent PAHs are known or suspected mutagens and/or carcinogens, and a handful of PAH derivatives are known to be more potent mutagens and/or carcinogens...
Throughout their lifetime individuals are exposed to complex mixtures of chemicals. The study of chemical mixtures is an internationally recognized research priority, but seemingly complex challenge. To reduce the intricacy of studying mixtures, researchers have identified different prioritization methods based on exposure or the toxicity of chemicals. However, understanding the...
In the past fifty years, per- and polyfluoroalkyl substances (PFASs) have become alarming global pollutants. In 2019, the United States (U.S.) Environmental Protection Agency (EPA) ultimately classified them as emerging contaminants and established an action plan to address PFAS and protect public health through developing, identifying, monitoring, and remediating current...
The discovery of new blue pigments is a field of great interest, as commercially available pigments present properties that make them undesirable such as poor sustainability, cost, and stability. By researching solid solutions with the melilite structure, we discovered a new solid solution Sr2Zn1-xNixGe2O7, with 0.1 ≤ x ≤ 0.6,...
Terrestrial land use activities present cross-ecosystem threats to riverine and marine species and processes. Specifically, pesticide runoff can disrupt hormonal, reproductive, and developmental processes in aquatic organisms, yet non-point source pollution is difficult to trace and quantify. In Oregon, U.S.A., state and federal forestry pesticide regulations, designed to meet regulatory...
Nowadays selective separation processes are sought after more than ever before. They are indispensable to meet the growing demand for individual rare earth elements, minor actinides partitioned from fission-produced lanthanides, as well as, overall, more concentrated and high-purity products. This research focuses on such separation techniques as solvent extraction which...
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Figure 1.3 Extractant Molecules Used for Development of ALSEP Process: (A)
HEH[EHP], (B
Climate change is causing people around the world to experience extreme temperature and air pollution events such as wildfires more frequently, and for longer periods of time. Extreme heat events have been widely associated with an increased risk of emergency room visits, occupational heat-related injuries and illnesses, and mortality overall...
Blue light exposure has been on the rise over the past several years as artificial light in the form of light emitting diodes (LEDs) have been increasing. These LEDs emit predominantly blue light through TVs, computer monitors, smartphones, tablets etc. Previous research in our lab determined that blue light accelerated...
Chlorpyrifos (CPF) is a widely used broad-spectrum organophosphate insecticide. Following exposures, CPF and its more toxic oxon metabolite (CPFO) elicit neurotoxic effects by inhibiting the activity of the acetylcholinesterase enzyme (AChE), resulting in altered fitness and death at high doses. Following exposure, organisms bioactivate CPF to CPFO through the Cytochrome...
Clean cooking technologies and fuels have been cited as a viable way to slow climate change and reduce the health and environmental impacts associated with traditional cooking devices used by 40% of the world. While engineers in the Design for Development sector have created hundreds of stove designs that perform...
Background
In the weeks following the first imported case of Ebola in the U. S. on September 29, 2014, coverage of the very limited outbreak dominated the news media, in a manner quite disproportionate to the actual threat to national public health; by the end of October, 2014, there were...
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Perspect 120: a30–a33. doi: 10.1289/ehp.120-a30 PMID: 22214548
8. Eysenbach G (2009) Infodemiology and
The purpose of this inventory is to detail the state of environmental justice in the Mid- Willamette Valley in an up-to-date, centralized format. The inventory is based on information from various government sources, and a survey to gather first-person perspective to take a pulse of the wellbeing of our community....
Growing evidence indicates that disrupting the microbial community that comprises the intestinal tract, known as the gut microbiome, can contribute to the development or severity of disease. As a result, it is important to discern the agents responsible for microbiome disruption. While animals are frequently exposed to a diverse array...
The influence of increasing temperatures on human health has been widely established across multiple health disciplines. Short-term temperature changes are associated with an increased risk of hospitalization and death overall and in a variety of health conditions, such as cardiovascular disease. Even as humans can self-regulate heat stresses, the elderly,...
The clean cookstove sector has long sought the tools and analysis methods needed to accurately quantify social, environmental, and economic impacts of projects in diverse settings. To respond to this need, Climate Solutions Consulting and Oregon State University have developed a novel integrated suite of sensors to collect fuel usage...
This thesis explores interrelationships between the geographical impact of recent hurricanes, rates of giardiasis and cryptosporidiosis in impacted communities, and effects of hurricanes on local water infrastructure systems. I obtained quantitative data on geographical hurricane attributes, demographic characteristics of populations struck by hurricanes, and confirmed cases of giardiasis and cryptosporidiosis...
The United States is at a crossroads when it comes to environmentally sound design. Social and consumer demands are shifting towards more environmentally conscious design and builders are noticing. However, green construction methods can often carry significant opportunity costs. This can lead to a level of “greenwashing” that not only...
Subtropical marine stratus clouds regulate coastal and global climate, but future trends in these
clouds are uncertain. In coastal Southern California (CSCA), interannual variations in summer stratus cloud
occurrence are spatially coherent across 24 airfields and dictated by positive relationships with stability
above the marine boundary layer (MBL) and MBL...
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emergency department visits, Environ. Health Perspect., 117(1), 61–67, doi:10.1289/ehp.11594.
LaDochy, S
Inherent nanomaterial characteristics, composition,
surface chemistry, and primary particle size,
are known to impact particle stability, uptake, and
toxicity. Nanocomposites challenge our ability to predict
nanoparticle reactivity in biological systems if they
are composed of materials with contrasting relative
toxicities. We hypothesized that toxicity would be
dominated by the nanoparticle...
Anthropogenic and natural stressors often interact to affect organisms. Amphibian populations are undergoing unprecedented declines and extinctions with pesticides and emerging infectious diseases implicated as causal factors. Although these factors often co-occur, their effects on amphibians are usually examined in isolation. We hypothesized that exposure of larval and metamorphic amphibians...
Full Text:
: 10.1289/ehp.8051
19. Longcore JE, Pessier AP, Nichols DK. Batrachochytrium dendrobatidis gen et sp nov, a
Exposure to arsenic early in life has been associated with increased risk of several chronic diseases and is believed to alter epigenetic programming in utero. In the present study, we evaluate the epigenome-wide association of arsenic exposure in utero and DNA methylation in placenta (n = 37), umbilical artery (n...
Exposure to arsenic early in life has been associated with increased risk of several chronic diseases and is believed to alter epigenetic programming in utero. In the present study, we evaluate the epigenome-wide association of arsenic exposure in utero and DNA methylation in placenta (n=37), umbilical artery (n=45) and human...
Mercury and arsenic are known developmental toxicants and environmental exposures are ubiquitous worldwide from natural and anthropogenic sources. Prenatal exposure to both contaminants are independently associated with adverse perinatal health outcomes and latent disease risk that could be in part mediated by epigenetic reprogramming events. Fetal programming events involving DNA...
American Indians presently face health risks posed by exposure to environmental pollutants through different exposure routes including: inhalation (e.g., air particles), ingestion (e.g., fish, water), and dermal contact (e.g., contact with water, soil). Geographic Information Systems (GIS) are increasingly being used in the Environmental Health arena as a tool for...
DNA methylation is a well-recognized epigenetic mechanism that has been the subject of a growing
body of literature typically focused on the identification and study of profiles of DNA methylation and their
association with human diseases and exposures. In recent years, a number of unsupervised clustering algorithms,
both parametric and...
Noise is an environmental issue uniquely harmful to public welfare but essential to a well-functioning modern economy. Given the prevalence of noise especially in urban soundscapes, noise pollution has been recognized as a negative externality and an environmental stressor and thus has become an issue in public policy. Yet, as...
This dissertation examined the association between HAP and respiratory health, both using simple proxy metrics, such as cooking fuel types, and actual measurements, such as household and personal measures of PM2.5 and BC. We found that simple proxy metrics can predict a portion of HAP levels, and associations with respiratory...