DNA is often described as the “blueprint for life”. In eukaryotes this information is contained within linear chromosomes of varying size and number. During cell division, the chromosomes must be faithfully segregated into each daughter cell to avoid disease and sustain life. This process is carried out by the kinetochore...
This research sought to identify the reasons physicians attributed for practicing in Oregon, the reasons for relocating out of Oregon, and the reasons for failures in recruiting physicians to Oregon. A random sample survey of 494 Oregon physicians identified the presence of economic and non-economic factors related to the recruitment...
PURPOSE Rural hospitals began to make significant changes in the 1990s by becoming integrated with larger health systems. The literature has correlated several key measures that determine the success of integrated health systems. These measures were quality, financial strength, community benefit, physician outcomes, and service changes. The purpose of this...
In response to genotoxic stress, ATR and ATM kinases phosphorylate H2A in fungi and H2AX in animals on a C-terminal serine.
The resulting modified histone, called γH2A, recruits chromatin-binding proteins that stabilize stalled replication forks or promote
DNA double-strand-break repair. To identify genomic loci that might be prone to replication...
Full Text:
. Lynch,a* Caitlin V. Mueller,a StevenFriedman,b Michael Freitag,b Zachary A. Lewisa
Department of
In response to genotoxic stress, ATR and ATM kinases phosphorylate H2A in fungi and H2AX in animals on a C-terminal serine.
The resulting modified histone, called γH2A, recruits chromatin-binding proteins that stabilize stalled replication forks or promote
DNA double-strand-break repair. To identify genomic loci that might be prone to replication...
In response to genotoxic stress, ATR and ATM kinases phosphorylate H2A in fungi and H2AX in animals on a C-terminal serine. The resulting modified histone, called γH2A, recruits chromatin-binding proteins that stabilize stalled replication forks or promote DNA double-strand-break repair. To identify genomic loci that might be prone to replication...
Shell-boring polychaetes pose economic risks for oyster aquaculture industries as they reduce the aesthetic quality of oyster products by creating unsightly mud-filled blisters on the inside of the shell. Recently there has been a reported uptick in infested oysters on commercial farms along the west coast of the US, which...
Transgenic biotechnology holds enormous potential as a tool to address global food insecurity. Transgenic food crops have been shown to increase food availability and food system security by incorporating disease, pesticide and drought resistance. Production costs of transgenic crops are lower due to the reduced need for costly pesticides and...
Ascorbic acid, or vitamin C, is well known as a co-factor for proline-hydroxylase and as an anti-oxidant. However, it is also capable of forming covalent bonds, particularly in the role of a nucleophile, henceforth termed 'ascorbylation'.
The ascorbylation of electrophiles can occur under physiological conditions. Furthermore, there are a number...
Histones, as part of nucleosomes, are responsible for DNA packaging in chromosomes. They also affect DNA expression by a multitude of post-translational modifications, especially prevalent on the amino terminus of histones. Co-activator protein complexes “write”, “read”, or “erase” histone modifications, and in balance determine which sections of DNA are free...
The federal government has spent considerable sums of money to
rehabilitate range lands administered by the Bureau of Land Management
(BLM). These investments have had varying effects on the production
and utilization of forage on these lands.
One of the most surprising results, according to BLM officials,
of the investments...
This dissertation is comprised of four studies on different elements of Populus biotechnology and genomic science: 1) growth improvement by recombinant DNA (rDNA) modification of gibberellin (GA) metabolism; 2) gene editing using zinc-finger nucleases (ZFNs); 3) induction of floral sterility by RNA interference (RNAi) of AGAMOUS (AG) gene homologs; and...
Dietary nitrate (NO3-), consumed primarily from leafy green and root vegetables, lowers blood pressure, improves vascular function and aerobic exercise performance. This performance-enhancing effect of nitrate supplementation is largely attributed to the increased bioavailability of the signaling molecule, nitric oxide (NO). Nitric oxide is a ubiquitous free radical signaling molecule...
Watching how Oregon State is working to combat some of the complex social issues that plague the world today by placing student success at the top of their strategic priority list, the Oregon State Investment Group (OSIG) believes that by leveraging capital markets we can play our part in helping...
Concurrent error detection (CED) is the detection of errors or faults in a circuit or data path concurrent with normal operation of that circuit. The general approach for CED is to calculate a check symbol for the inputs to the circuit under operation, predict the check symbol that will result...
Radiotelemetry was used to study the seasonal movements and habitat use of adult westslope cutthroat trout Oncorhynchus clarki lewisi in Roberts
Creek and Rail Creek, headwater tributaries of the John Day River, Oregon,
from September 2000 to December 2001. The objectives were to (1)
describe adult cutthroat trout life history...
Twenty-six Holstein and 18 Jersey multiparous cows in a randomized block design were assigned by calving date and breed to a non-anionic prepartum diet (CTRL) or a treatment diet containing a commercial anionic salt supplement (Animate®). Control and treatment diets were formulated to a dietary anion-cation difference (DCAD) of 21.3...
The collision of the Indian subcontinent with Asia beginning 40 million years ago
produced the Himalayan orogenic belt, the largest continental collision belt active today. The foreland fold-and-thrust belt in northern Pakistan consists of the Salt Range-Potwar Plateau area. In this region the distance from the Main Boundary Thrust(MBT) to...
On New Year's Eve 1993, there was little indication
that popular President Carlos Salinas de Gortari was about
to take a monumental fall. Mexico was in the midst of
unprecedented prosperity. The world's oldest ruling
political party, Mexico's PRI, enjoyed substantial support.
Allegations of corruption within an authoritarian regime
were...
The influence of protein adjuncts and variations in pH on the
cook-cool loss, moisture content, and texture of squid gels was
investigated. Break force (P [greater than or equal to] .025), deformation to break (P [greater than or equal to] .01)
and cook-cool loss (P [greater than or equal to]...
The addition of thin-film alloy magnetic materials to integrated circuit processing enables a number of novel monolithic circuits. Examples include fully integrated magnetic field sensors, signal and power galvanic isolation circuits, and power supplies on chip (PwrSoC). There are several benefits to integrating these traditionally off-chip devices, including improved manufacturability,...
Eight species of Lathvrus (Fabaceae, Faboideae) endemic to the
Pacific Coast of North America were the subject of a systematic
investigation. Taxa studied included Lathvrus vestitus, Nutt. ex T.
& G., L. laetif lorus Greene, L.. iepsonii Greene, £,. splendens
Kellogg, L. polvphvllus, Nutt. ex T. & G., L. holochlorus...
Ecosystem nitrogen (N) supply strongly influences the availability and cycling of other essential nutrients in temperate forests, especially calcium (Ca). Short-term additions of N that exceed ecosystem demands often increase dissolved nitrate fluxes and decrease soil pH, which can stimulate soil Ca loss. However, the long-term effects of high N...
The United States is a global leader in agricultural productivity. Much of its productivity growth can be attributed to public investments in agricultural research and development, starting in the 19th century and continuing until today. Past studies have shown high returns to agricultural research investments, but publicly funded agricultural research...
Fisheries models often assume that discarded undersized fish and target species will survive and contribute to future recruitment and yield. If smaller fish are more susceptible to capture stressors than larger fish, then the assumption that smaller discards would contribute to recruitment may not be true. We tested the hypothesis...
The study of the infra-specific ranks (i.e., subspecies and variety) can be considered
the study of the process of speciation. Astragalus lentiginosus Douglas ex Hooker
(Fabaceae) is the most taxon rich species in the U.S. flora currently including 40
taxonomic varieties. These varieties were described using traditional taxonomic
methods primarily...
Coastal communities throughout the US West Coast and elsewhere are facing the daunting task of preparing for climate change impacts, particularly the hazards from increased flooding and erosion. With sea-level rise, changing storminess patterns, and possible changes to the frequency and severity of major El Niño events, communities are already...
This annotated bibliography was compiled to provide a comprehensive list of sources on the ecological factors that affect forest regeneration. Abstracts from 494 publications are indexed by author, species, and subject, and are arranged into 4 major sections. Topics include the effects of biotic factors, abiotic factors, and stand and...
The major purpose of this study was to test the relationship between
students' cerebral lateralization for the Arabic language and
their achievement in science. A secondary purpose was to investigate
handedness as a factor in that relationship. The experiment was conducted
in the City of Jeddah, Saudi Arabia, using dichotic...
PREMISE OF RESEARCH: Anatomically preserved platanaceous inflorescences have been found in rocks of Late
Cretaceous (Coniacian) age at the Eden Main locality on Vancouver Island, British Columbia, Canada.
METHODOLOGY: Specimens occur in calcium carbonate concretions near the base of the Nanaimo Group
(Comox Formation) and are studied with the cellulose...
The purpose of this research study was to enhance understanding of successful conflict management by community college Presidents through highlighting and describing conflict experiences with the faculty union or the board of trustees in a community college context. The following questions guided the research: (a) How do community college Presidents...
Dynamic seascapes, which are classified using a combination of remotely sensed data and model output, represent a potential tool for dynamic ecosystem-based management in marine systems. This work explores the utility of seascape classification in the context of marine resource management by examining two case studies: one involving biological relationships...
Purple nutsedge [Cyperus rotundas L.) has been recognized as one of the
most troublesome perennial weeds of agricultural lands in tropical and some
temperate regions. This research sought to determine the effects of timing of
herbicides, shading, and soil moisture on plant population growth and tuber
production of purple nutsedge...
The contribution of delayed adaptive reiteration to crown maintenance was explored across a wide range of adjacent open space conditions in early-mature (approximately 60 year old) Douglas-fir located on the eastern slope of Oregon’s Coast Range. The stands had experienced uniform thinning in 1964-65 and 1980-81 to release dominant and...
Mutation of repetitive DNA by repeat-induced point mutation (RIP) is a process that occurs in many filamentous fungi of the Ascomycota during the sexual cycle. Concurrently, direct DNA repeats are often deleted by homologous recombination at high frequency during the sexual cycle. Thus, the processes of RIP and deletion compete...
Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
While there are many more species of reptiles in the tropics than in temperate
latitudes, relatively little is known about the natural history of tropical species of
snakes. Even basic information, such as reproductive ecology and behavior, is lacking. Patterns of reproduction in tropical species differ from patterns in temperate...
Many economically important Pacific salmon fisheries along the west coast of North America are mixed-stock, recreational systems, in which managers strive to account for interactions between fish, anglers, and management policy while balancing fishery access against conservation of vulnerable stocks. Specific challenges facing fisheries managers include limited control over angling...
Malaria is the world’s most important parasitic infectious disease, and is a major cause of mortality and morbidity in many developing countries. In this dissertation I study the interaction of malaria and economic development at both the macro- and micro-economic levels.
In the first essay I examine the economic impact...
Interest is expanding for the potential role of estuaries, particularly seagrass and salt marsh habitats, to sequester carbon, mitigate ocean acidification, and support abundant fisheries. The important functions of estuaries are part of a broader set of ecosystem services, or benefits to humans, which are regulated by ocean and watershed...
Feedlot finishing of beef cattle in Southern Alberta involves
income risk due to the variability of prices of feeders, feed and
finished cattle. Several strategies are available to reduce this
risk, including hedging of cattle on feed, participation in a Federal-
Provincial government and producer established income stabilization
program for...
Dysfunction of mitochondria has been linked to aging and the pathogenesis of many degenerative diseases. Aside from their primary function in energy production, mitochondria are considered as a major source and target of reactive oxygen and nitrogen species (ROS/RNS) in cells as well. The mitochondrial thiol proteome is a subset...
American meteorology was synonymous with subjective weather forecasting in the early twentieth century. Controlled by the Weather Bureau and with no academic programs of its own, the few hundred extant meteorologists had no standing in the scientific community. Until the American Meteorological Society was founded in 1919, meteorologists had no...
Phytochemicals from cruciferous vegetables, such as broccoli, contain a multitude of bioactive compounds that prevent and suppress cancer and promote optimal health. Some of the health promoting effects of cruciferous vegetables are attributed to a class of compounds known as isothiocyanates (ITCs), a potent nuclear factor erythroid 2–related factor 2...
Obesity and metabolic syndrome (MetS) affect over 1.9 billion adults and 12.7 million youth in the US. If all of today’s obese American youth become obese adults, the total societal costs over their lifetime may exceed $1.1 trillion. We show that feeding rodents a high-fat diet supplemented with xanthohumol (XN)...