The overarching objective of this paper is to identify how the three tiers of human well-being (i.e., economics, ecosystems, and social) are linked to healthy landscapes and a species-rich ecosystem mediated by healthy cougar populations. Does the cougar help mitigate Oregon’s Lyme disease, chronic wasting disease (CWD), or elements of...
Zebrafish are capable of fully regenerating organs and tissue such as their caudal fin, which is similar to a human regrowing an arm or a leg. In contrast, most mammals including humans have a greatly reduced capacity for wound healing. The ability of zebrafish to undergo this regenerative process, called...
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RobertL. Tanguay
Zebrafish are capable of fully regenerating organs and tissue such as
Ubiquitous fine particulate matter (PM2.5) exposures significantly impact global public health, yet little is known about the mechanisms causing these known adverse health effects. Oxidative stress due to PM2.5 associated chemical constituents, such as polycyclic aromatic hydrocarbons (PAHs), is a proposed possible mechanism for PM2.5 mediated health effects. Variations in...
Nanoparticles (NPs), defined as materials having at least one dimension (height, width, diameter) in the nanoscale, are increasingly being incorporated into a wide variety of products and are replacing traditional bulk materials in many applications. This is because they can be more efficacious, more sustainable, and can have unique characteristics...
Since 2007, electronic cigarette (e-cigarette) sales in the U.S. have surpassed those of tobacco cigarettes. This is due, in part, to manufacturer’s claims that they are a safer alternative to tobacco cigarettes. However, formaldehyde, acrolein, and diacetyl have been detected in e-cigarettes and public knowledge of e-cigarette composition and potential...
The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that is a member of the basic helix-loop-helix PER-ARNT-SIM (bHLH/PAS) protein family of cellular sensors. The AHR is conserved across multiple animal phyla and is required for proper vertebrate development. A structurally diverse group of chemicals, including polycyclic aromatic...
Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants that occur in complex mixtures. These environmental mixtures can consist of both parent PAHs and their derivatives. Several parent PAHs are known or suspected mutagens and/or carcinogens, and a handful of PAH derivatives are known to be more potent mutagens and/or carcinogens...
Polycyclic aromatic hydrocarbons (PAHs) are among the most widely known and studied environmental contaminants, originating from a range of natural and anthropogenic sources. PAHs are known to occur in the environment as complex mixtures, containing both unsubstituted PAHs, as well as a range of PAH derivatives. Among the less-studied of...
There are more than 87,000 chemicals in current use with little to no toxicity information available. Assessing such a large number of chemicals using traditional methods would take an unreasonable amount of time and money, and require the use a large number of animals. The incorporation of high-throughput in vivo...
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RobertL. Tanguay
There are more than 87,000 chemicals in current use with little to no
Laboratories around the world are using the zebrafish model for biomedical research and conducting investigations using morphological, physiological, behavioral, and genomic endpoints. All assays provide information, but physiological and behavioral endpoints or phenotypes are a fast way to understand how an animal is responding to its environment. We investigate the...
The numerous different types of nanomaterials and paucity of reliable in vivo information on toxicity has resulted in enduring uncertainties associated with health and safety risks, thereby slowing progress in nanotherapeutic assessment and development. This dissertation explores how the embryonic zebrafish model can be applied to prioritize commonly used nanomaterial...
Polycyclic aromatic hydrocarbons (PAHs) and oxygen-substituted PAHs (OPAHs) are environmental contaminants present in urban air, dust, soil and water resulting from incomplete combustion of organic materials or fossil fuels; found in crude oil and coal; and formed through photoxidation or biotransformation of microbial. It is widely recognized that PAHs pose...
There has been a rapid increase in technological advances in the biological sciences that has contributed to an increase in societal issues that require attention from both scientists and citizens. Consequently, there is a need for the development of biologically literate citizens who have the ability to use their knowledge...
Firemaster 550 (FM550) is an additive flame retardant mixture used within polyurethane foam and is increasingly found in house dust and the environment due to leaching. In this study, we sought to investigate mono-substituted isopropylated triaryl phosphate (mITP), a major component of FM550, which has been shown to cause cardiotoxicity...
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. Defining toxicity mechanisms for this large family of multi-ring structures and substituted derivatives is a substantial challenge. Several PAHs, such as benzo(a)pyrene (BaP), are mutagenic, toxic to wildlife, and classified as probable...
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RobertL. Tanguay
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the
Billions of pounds of bisphenol A (BPA) are produced annually around the globe for the manufacture of numerous consumer products, including polycarbonate food and water containers, the protective resin linings of food cans, thermal printing paper, and dental fillings. BPA exposure during nervous system development has been associated with learning...
Incorporation of nanoparticles (NPs) into consumer products is on the rise and human exposure to NPs is unavoidable. Currently, there is insufficient data to assess the safety of nanoparticles. I conducted a series of five studies using the zebrafish model to determine which NP components (i.e., core material or surface...
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RobertL. Tanguay
Incorporation of nanoparticles (NPs) into consumer products is on the
rise
The complexity of numerical ocean circulation models requires careful checking with a variety of test problems. The purpose of this paper is to develop a test problem involving Rossby and gravity waves in a two-layer fluid in a channel. The goal is to compute very accurate solutions to this test...
Vitamin E was first described in 1922 as an unknown factor required for impregnated rats to carry their offspring to term. In fact, when vitamin E was chemically characterized it was given the name "tocopherol" derived from the Greek: tokos = childbirth; phero = to bear; and –ol, indicating an...
Understanding continental crust formation and modification is a fundamental and longstanding geologic problem. Influx of mantle-derived basaltic magma and partial melting of the crust are two ways to drive crustal differentiation. This process results in a low density upper crust and denser, more refractory lower crust, creating significant and vastly...
Numerous human conditions would be improved if therapies to encourage tissue regeneration were available. The goal of regenerative medicine is to encourage the body's intrinsic ability to repair and restore tissues lost by disease, injury or aging. While certain vertebrates have the inherent capacity to regenerate, mammals do not. To...
Fluorinated chemicals (FCs) have been used since the 1950s in many industrial and commercial applications because of their unique properties such as chemical inertness, resistance to heat and their ability to repel water and oils. Concerns regarding potential environmental or human health risk from FCs exposure have emerged due to...
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RobertL. Tanguay
Fluorinated chemicals (FCs) have been used since the 1950s in many
The emerging field of regenerative medicine is mainly approached by two different aspects. First is the use of stem cell based models to generate a suite of differentiated cells for therapeutic applications and the alternative approach is to utilize the non-mammalian models that have the inherent capacity to regenerate their...
Low reproductive success has been typical of high elevation populations of the Hawaiian goose (Branta sandvicensis) or nēnē. Researchers identified predation and inadequate nutrition as limiting factors. Reproductive success remained low in most years despite on-going predator control programs. I used a supplemental feeding program over two breeding seasons in...
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RobertL. Jarvis
Low reproductive success has been typical of high elevation populations
Dithiocarbamates are widely used agricultural pesticides, industrial chemicals and
effluent additives. DTCs and their related compounds have historical and current
relevance in clinical and experimental medicine. DTC developmental toxicity is well
established, but poorly understood. Dithiocarbamates according to the U.S. EPA have a
mechanism of action involving, "the inhibition of...
Invasion by nonnative brook trout (Salvelinus fontinalis) often results in replacement of bull trout (Salvelinus confluentus) in western North America, but the causal mechanisms are not well understood. Removal of brook trout from 1992 to 2000 from Sun Creek in southern Oregon, provided an opportunity to investigate the changes in...
I investigated the relationship between harlequin duck (Histrionicus histrionicus) behavior and lack of recovery from the Exxon Valdez oil spill in Prince William Sound, Alaska. First, I evaluated the hypothesis that harlequin ducks in winter have little flexibility to increase foraging time in response to disturbance because they are constrained...
Current riparian management objectives in the Pacific Northwest promote both retention of existing conifers and conversion of hardwood-dominated areas to conifers. Although understanding of relationships between riparian vegetation and salmonid prey availability is growing, temporal variation in these relationships is poorly understood. Seasonal fluxes in availability of aquatic and terrestrial...
Although widely studied in many portions of North America, little is known about the specific habitat requirements of mallard ducks (Anas platyrhynchos) during the breeding season in western Oregon. I radio-marked 72 female mallards in the Willamette Valley of Oregon in March-April 1995-96 to document wetland habitat selection during pre-nesting...
Freshwater wetlands in the Sacramento Valley provide breeding, wintering, foraging and stopover habitat for migratory and resident birds. With a loss of 95% of historic freshwater wetlands, the restoration of wetlands on private land could provide important habitat for birds. Documentation and monitoring of bird use on previously restored wetlands...
The 1989 Exxon Valdez oil spill was a major perturbation of nearshore habitats of Prince William Sound, a wintering area for harlequin ducks (Histrionicus histrionicus). This research was designed to evaluate harlequin duck population recovery from the oil spill from 1995 to 1998, using a demographic approach to assess both...
Well water levels and ditch flow were used to evaluate road-induced changes in surface and subsurface flow for two sites (Trocadero and Polk) in southeast Alaska. At the Trocadero Site, low water levels before and peak water levels during a storm were used to test for differences in subsurface water...
Evaporation was studied along the Middle Fork of the John Day River in northeastern Oregon. Evaporation pans and various meteorological sensors recorded data at nine sites during the summer of 1998; measurements were made at each site over a 3-4 day period. A Dalton-type evaporation model was produced using water...
I radio-tagged 191 Hatch-Year (HY) and After-Hatch-Year (AHY) female northern pintails (Anas acuta) in the San Joaquin Valley (SJV), California and studied their movements, habitat use and survival during August March, 1991-94.
Overall, 94.3% wintered in central California; the highest percentage left during
the 1991 drought. Tulare Basin and Mendota...
My objectives were to: 1) develop a point count technique for estimating relative
abundance of band-tailed pigeons (Columbafasciata monilis), 2) determine the
availability, distribution, and interspersion of mineral sites, and nesting and foraging cover in relation to abundance of band-tailed pigeons in west-central Oregon, and 3) test the hypothesis that...
We sharpen our view of an eastern boundary current region during
the upwelling season through the analysis of several data sets.
We focus on the mesoscale flow field off of northern California,
observed during the Coastal Transition Zone (CTZ) experiment of 1988.
First, we estimate tidal currents in the region...
Pacific Coast band-tailed pigeons (Columba fasciata) have declined markedly
during the past several decades. Despite implementation of increasingly restrictive
hunting regulations, populations have shown minimal signs of recovery. I radio-marked
127 adult band-tailed pigeons in the central Oregon Coast Range in April-May of 1993-95
to document nesting chronology and productivity,...
Several types of channel morphology measurement parameters used to
characterize fish habitat of small streams are refined, developed and evaluated in terms
of their accuracy, precision, and sensitivity to disturbance. Data for 74 stream reaches
in Oregon and Alaska are used in analysis. Over half the reaches are from a...
Subsurface inputs into lotic systems are a primary mechanism for cooling streams with high ambient water temperatures. Objectives of this study include: 1) to determine the effectiveness of Forward Looking Infrared (FLIR) thermal imagery to detect shallow
aquifers, 2) to characterize certain physical, spatial, and temporal characteristics of the fluvial,...
This study was conducted to determine how the size and orientation of large
wood placed in streams in combination with peak flows, substrate and channel gradient
affect pool volume, surface area and maximum depth in two coastal Oregon streams.
Eighteen Douglas-fir (Pseudotsuga menziesii) logs were placed in each of two...
Diurnal time budgets and habitat use patterns of breeding Ugashik marbled godwits
(Limosa fedoa beringiae) were studied on the north-central portion of the Alaska Peninsula
during spring and summer 1995-1996. Marbled godwits were observed from blinds and
behaviors were described for the four phases of the breeding season: pair-formation, egg-laying,...
The specific habitat requirements of harlequin ducks (Histrionicus histrionicus
Linnaeus 1758), which breed in the Pacific Northwest, are largely unknown. I captured
and attached radio transmitters to 42 female harlequins (36 paired and 6 unpaired) in the
central Cascade Range of Oregon in 1994 and 1995. Breeding pairs used 3rd...
The Upper Sprague River Watershed (North and South Forks of the Sprague River) in south central Oregon provides important habitat for
salmonid species, including native bull trout (Salvelinus confluentus) and redband trout (Oncorhynchus mykiss ssp.). Concern over the loss of viable habitat for these species has increased due to reductions...
Object Watershed Link Simulation (OWLS) is a physically based watershed model. In the OWLS
model, a watershed is defined as a three-dimensional object with linkages between cells and their
attributes (e.g., area, slope, soil type, etc.). A cell is defined as the linkages of edges and their attributes
(e.g., length,...
The Upper Grande Ronde River Watershed in northeastern Oregon is considered important habitat for threatened stocks of chinook
salmon (Oncorhynchus tshawytscha). Documented reductions in channel complexity and riparian vegetation within the watershed have increased concern over loss of viable habitat. An important component of salmonid habitat is stream temperature during...
Through the trapping of sediment behind dams, the
presence of beaver in a watershed may cause substantial
changes to fluvial and geomorphic processes. In an
effort to investigate sedimentation patterns in beaver
ponds in the Oregon Coast Range, a case study was made of
the annual accumulation of sediment in...
Meyer's Canyon, a tributary of Bridge Creek in the John Day
Basin, is a deeply incised valley fill in northcentral Oregon. The
current channel is incised to the Cretaceous and Tertiary bedrock.
To determine the precedence of the current incision and the variation
and timing of depositional sequences, the sediments...
Breeding habitat of Harlequin ducks (Histrionicus
histrionicus) was studied in eastern Prince William Sound,
Alaska, during 1991 - 1993. Streams in Prince William
Sound were surveyed for Harlequin ducks and monitored with
mist nets. Physical characteristics of 24 Harlequin
breeding streams were compared to those of 24 streams not
used...
Chilling requirements of 43 apple and 38 pear cultivars
were estimated over a 2 year period by cutting shoots in the
field at weekly intervals and forcing them in a warm
greenhouse for 4 weeks. For apples, the mean values ranged
from 490 Chill Units (CU) +- 1 for 'Dorsett...