Accurate chromosome segregation and cell cleavage are critical to maintaining genomic integrity. Both events involve the spindle apparatus, but the exact mechanics is as puzzling as the contradicting models proposed in the last two centuries. In this dissertation, current prevailing models of chromosome segregation and cell cleavage are tested using...
The effects of incorporation of selected biocides on physical and mechanical properties of aspen strandboard were assessed using five copper-based preservatives or zinc borate at three retention levels. Tebuconazole or 4,5-dichloro-2-N-octyl-4-isothiazolin-3-one (DCOI) were added as co-biocides to selective copper-based treatments. Mold box tests showed that only panels treated with DCOI...
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Jeffery J. Morrell Frederick A. Kamke
The effects of incorporation of selected biocides
Climate change is occurring at an increasingly rapid rate, with impacts heightened in the cold regions of the world including the Arctic. Warming effects are widespread, with one impacted process – freeze-thaw cycles – increasing in frequency and potentially triggering additional changes in permafrost soils that have previously acted as...
Public lands in the Pacific Northwest are managed for multiple uses including timber production, recreation and aesthetic value, maintaining wildlife habitat, conserving native species, and carbon storage. Wildfires impact large areas encompassing broad environmental conditions. Interactions among underlying environmental gradients and alteration of overstory competition by fire of varying severities...
Abstract Watershed-scale fate/transport modeling of contaminants is a tool that scientists and land managers can use to assess pesticide contamination to stream systems. The Catchment Modeling Framework (CMF) is a catchment-scale fate/transport modeling tool. It was developed to help scientists and land managers assess the effects of possible land-use decisions...
Hallmarks of aging include the accumulation of aberrant proteins and a lower resistance to stresses. Because the endoplasmic reticulum (ER) functions to fold proteins and possesses unique stress sensing pathways, the central hypothesis of this dissertation is that the ER is a target of cellular aging and significantly underlies these...
Landscape positions have been used to determine soil properties. My soil study in Monteverde on the Pacific slope of Costa Rica was designed to examine soil-landscape relationships for sites with various land use histories and management. Soil pits were dug at Nacimiento y Vida, Crandell, Curi-cancha, La Calandria, and Finca...
An increase in anthropogenic activities since the industrial revolution, primarily due to burning of fossil fuels and changes in land cover, has resulted in a steady increase in the global mean atmospheric CO2 concentrations. While there is unequivocal scientific evidence on global warming and its multidimensional impacts on natural and...
Natural products from both terrestrial and marine sources represent a significant source of novel drug leads, and have previously been developed into clinically-approved agents for the treatment of various human diseases. This work represents the biological characterization of the mechanistic basis for activity of several natural product structures in models...
Coibamide A is a methyl-stabilized cyclic depsipeptide with a lariat side chain that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups program based in Panama. Previous testing of this potent and selective growth-inhibitory agent in the National Cancer Institute (NCI) in vitro 60 human...
Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by the progressive degeneration of motor neurons. Dominantly-inherited mutations to the antioxidant enzyme Cu,Zn superoxide dismutase (SOD1) cause 3-6% of all ALS cases. The complete mechanism behind the toxicity of mutant SOD1 remains unclear, although significant evidence points to aberrant or...
Chemicals must be bioavailable for there to be a potential for exposure and consequent risk to human or environmental health. Passive sampling devices (PSDs) are used to quantify the time-integrated concentration of bioavailable contaminants. We demonstrate that PSDs can be paired with the zebrafish developmental toxicity bioassay to produce site-specific,...
Mutations to superoxide dismutase were the first proven cause of Lou
Gehrig’s disease (amyotrophic lateral sclerosis; ALS) implicating superoxide in
the selective death of motor neurons that characterizes ALS. Nitric oxide
competes effectively with superoxide dismutase for superoxide to form the
powerful oxidant peroxynitrite. Endogenous formation of peroxynitrite can kill...
Riparian zones are ecotones between terrestrial and aquatic ecosystems. Processes in streams are strongly influenced by riparian forest communities, age, stage and structure. Temperate forests across much of North America, including riparian areas, are recovering from historic land clearing with many stands in the stem-exclusion phase of development in which...
Two distinct strategies were explored for the enantioselective synthesis of α-heteroatom substituted alkyl boronic esters by stereoselective reagent-controlled homologation using transient chiral carbenoid reagents CHYMX (Y = heteroatom, X = nucleofuge, M = electrofuge). In the first case, a stereospecific reagent-controlled homologation (sStReCH) approach to α-alkoxyalkylboronates using α-metalated S,O- and...