In October, 2016, presidential candidate Donald Trump released a document titled “Contract with the American Voter.” This document promised, among many things, that within his first 100 days of his potential presidency, he would repeal and replace Obamacare. When he was unable to fulfill that promise, he employed rhetorical tactics...
A fundamental difference between prokaryotic and eukaryotic cells is the presence of membrane bound organelles in eukaryotes. The dynamics of membrane trafficking within the cell are responsible for everything from intercellular communication and cell homeostasis, to mitosis, cell migration, and differentiation. These processes require exocytosis and compensatory endocytosis, often working...
The subaerial beach, composed of sand dunes and the foreshore, provides a natural buffer zone between vulnerable land and the dissipation of storm wave energy due to wave breaking. The natural beauty of this region is attractive to people, and as a result, significant investment has been placed in this...
Sensory hair cells convert mechanical motion into chemical signals. Otoferlin, a six-C2 domain transmembrane protein linked to deafness in humans, is hypothesized to play a
role in exocytosis at hair cell ribbon synapses. To date however, otoferlin has been
studied almost exclusively in mouse models, and no rescue experiments have...
Full Text:
Mouse Otoferlin
Chatterjee, P., Padmanarayana, M., Abdullah, N., Holman, C. L., LaDu, J.,
Tanguay, R
Sensory hair cells convert mechanical motion into chemical signals. Otoferlin, a six-C2 domain transmembrane protein linked to deafness in humans, is hypothesized to play a
role in exocytosis at hair cell ribbon synapses. To date however, otoferlin has been
studied almost exclusively in mouse models, and no rescue experiments have...
Sensory hair cells convert mechanical motion into chemical signals. Otoferlin, a six-C2 domain transmembrane protein linked to deafness in humans, is hypothesized to play a
role in exocytosis at hair cell ribbon synapses. To date however, otoferlin has been
studied almost exclusively in mouse models, and no rescue experiments have...
Sensory hair cells convert mechanical motion into chemical signals. Otoferlin, a six-C2 domain transmembrane protein linked to deafness in humans, is hypothesized to play a
role in exocytosis at hair cell ribbon synapses. To date however, otoferlin has been
studied almost exclusively in mouse models, and no rescue experiments have...
Quinone outside Inhibitor (QOI) fungicides are one of the most widely used fungicide classes (FRAC 11) in the world. This popularity is the result of their ability to effectively manage a wide array of economically important pathogen species on a broad range of crops. While having mostly preventative activity, some...
We examine the interactions and feedbacks between bathymetry, waves, currents, and
sediment transport. The first two pro jects focus on the use of remote sensing techniques
to expand our knowledge of the nearshore. Due to the plethora of snap-shot data that is
available from satellites and their distribution via Google...
The electrical output of solar panels is reduced when dust covers the panels, but the air movement produced by a flying drone can be used to remove this debris. This research project will study the effectiveness of a quadcopter drone in dusting a solar panel. A solar panel was covered...
The greater sage-grouse (Centrocercus urophasianus: hereafter; sage-grouse) population in Modoc County California is geographically isolated and has been subsidized by translocation to prevent inbreeding depression since 2005. Despite significant efforts to increase the population through translocations and habitat improvement by cutting encroaching western juniper (Juniperus occidentalis), only a single lek...
The purpose of this honors thesis research project is to investigate the molecular causes of childhood and infant T-cell acute lymphoblastic leukemias. T-cells are the work horses of the immune system, and like any organ, must develop properly to be fully functional. Improper development of thymocytes into T-cells can lead...
Vaccinia virus (VV) is a large double-stranded DNA virus that is a prototypic member of the orthopoxvirus family. Previous works has showed that three of the major structural proteins found within the mature VV virion core 4a, 4b, and 25K are produced from higher molecular weight precursors at late times...
Conservation is, among other things, the expression of a relationship between humans and nonhuman nature. This relationship can be described empirically using the methods of social science, but it can also be prescribed in the form of philosophical arguments. Scholars in the field of environmental ethics have discussed and debated...
Student conduct has become increasingly significant in higher education as demands to address campus safety, student behaviors, and classroom management are increasingly prominent. Existing research focuses on the efficacy of student conduct policies and practices, but has not established how individuals understand student conduct as a myth, or a concept...
Although science is widely accepted as a fundamental source of information underlying decisions about forest management and conservation, considerably less attention has been paid to the inevitable role that normative values and beliefs play in such decisions. This thesis highlights the normative dimensions of "ecological forestry," a strategy of forest...
Innovative nanoelectromechanical switches (NEMS) have the prospects to reduce device actuation voltages as compared to traditional semiconductor devices. Current research on NEMS seeks to avoid irreversible adhesion at the nanoscopic level, which results in device failure. Minimizing leakage currents and increasing device longevity are additional goals of this approach. The...
As more wind farms are connected to the grid, the variable nature of wind energy begins to influence grid stability. Energy storage could help smooth the variable nature of wind energy. Laboratory demonstration and exploration of the interaction between different energy storage devices and wind energy could help improve and...
On January 8th, 2011 tragedy struck in Tucson, Arizona. A gunman opened fire on Representative Gabrielle Giffords' "Congress on Your Corner" event, wounding thirteen and killing six ("Arizona Shooting"). Four days later, President Obama spoke to a grieving crowd at the University of Arizona's McKale Memorial Center. This study seeks...
Using wave and wind data from nearby buoys and gauges, real time
kinematic global positioning system (RTK-GPS) and light detection and ranging
(lidar) topographic survey data, and a robust video record, we have quantified the
Large Scale Coastal Behavior (LSCB) of a dissipative end member beach in the
Pacific Northwest....
In the past, classification systems for the analysis of morphodynamic variability have been developed in an attempt to understand large scale coastal behavior. The motivation behind the creation of these classification systems has been to provide a framework of analysis, in order to understand large scale response to seasonal variability,...
This thesis presents an examination of the nearshore wave bottom boundary layer
under conditions of significant sediment response. Using both field observations and
simple models, the response of the bottom boundary layer to random waves is shown to
have a complex behavior. First, the linearized wave bottom boundary layer governing...
Beach response to overwash processes is a topic of significant importance. Two
particular aspects of this topic were chosen for detailed analysis: the distribution of
maximum wave runup elevations and the cross-beach celerity gradient of overwash bores
on natural beaches. Data were collected using both traditional nearshore instrumentation
and recently...
A field experiment designed to test the hypothesis that infragravity and lower frequency waves influence the patterns of erosion and deposition on the beach foreshore has been carried out. The data show coherent fluctuations in the foreshore sediment level which can be related to low frequency wave motions. The fluctuations...
Waves are the primary input of energy in the nearshore region, and together with the currents forced through the transfer of momentum that occurs during the wave breaking process they are the principal mechanism for sediment transport in the nearshore. The basic physics of waves and currents are thought to...
The longshore variability of the coastal response to hurricanes may be examined within the framework of a storm-impact scaling model that compares spatially-variable beach morphology and fluid forcing. The relative elevations of dune height and storm-induced water levels are used to define three impact regimes (swash, collision, and overwash), within...
Wave-induced circulation is the defining characteristic of the nearshore. Within this region, the constant feedback cycle between incoming waves, wave-generated currents, and the mobile sediment bed is responsible for the evolution of complex patterns in nearshore and beach morphology. Central to our understanding of this system is knowledge of the...
Field measurements of onshore and longshore velocities in the surf zone have been obtained on Martinique
Beach, Nova Scotia, for the purpose of investigating the dynamics of the infragravity band (0.003-
0.03 Hz) of the spectra. A total of35 data runs were obtained during a 1-week period. Of particular interest...
Pyrenophora tritici-repentis (Ptr) is the necrotrophic fungus responsible for tan spot of wheat (Triticum aestivum). Ptr causes disease on susceptible wheat cultivars through the production and secretion of host-selective toxins (HSTs). HSTs are compounds that are only known to be produced by fungi and considered to be primary determinants of...
The objective of this study was to investigate load paths in an existing light-frame wood structure with complex geometry, using previously established computer modeling methods. The structural model is derived from an existing, multi-level residence located in Corvallis, Oregon. For the purpose of this study, the existing structure was simplified...
Osmotic stress is a common challenge faced by organisms in environments with variable salinity or aridity. Understanding the evolutionary mechanisms underlying adaptation to osmotic stress may have wide applications, including management of populations experiencing climate change, or engineering industrial organisms involved in processes such as fermentation. While Saccharomyces cerevisiae is...
Successful prediction of nearshore sediment migration is important in determining the vulnerability of a coastline. During energetic wave climates (storm events) sediment rapidly erodes from beaches and is deposited offshore. In subsequent milder wave conditions, the sediment migrates shoreward, accreting on the beach and helping to protect the coastline. It...
The computational identification of gene Transcription Start Sites (TSSs) can provide insights into the regulation and function of genes without performing expensive experiments, particularly in organisms with incomplete annotations. High-resolution general-purpose TSS prediction remains a challenging problem, with little recent progress on the identification and differentiation of TSSs which are...
The rip current field resulting from the transformation of surface gravity waves over offshore submarine canyons is studied. Employing a wave transformation model and a wave-induced circulation model over observed bathymetry we find that rip current circulation cells exist with alongshore spacing of O(1OOm) even though the nearshore bathymetry displayed...
Plant-pollinator mutualisms are one of the most prevalent and economically important mutualisms in nature. Like many other ecological systems, plant-pollinator communities are threatened by anthropogenic activity, both directly (e.g., habitat conversion and fragmentation) and indirectly (e.g., climate change). While we are aware of many of the activities that adversely impact...
National Geographic’s June 2018 magazine titled “Planet or Plastic?” drew attention to a growing problem throughout the world: ocean plastic. The eight plastic-related articles in the magazine are an example of science communication as a critical method of not only disseminating information but also raising awareness of the marine debris...
In shallow water, any two waves of the same frequency are shown to produce complex patterns of
drift velocity above the sea bed. If the longshore components λ₁, λ₂ of the wave numbers of the two
waves are different, these steady flow patterns exhibit a longshore periodicity of wave number...
We investigate, theoretically and experimentally, the problem of modeling depth-integrated (2DH) surf zone circulation on an alongshore-nonuniform natural beach, with waves approaching from an arbitrary angle. An approximate theoretical model is developed, which captures the important effect of advection in the alongshore dynamics, and shows that a nondimensional parameter Re[subscript]s...
This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Coastal Education and Research Foundation (CERF) and can be found at: https://doi.org/10.2112/SI65-235.1
Simple parameterizations of dune erosion are necessary for forecasting erosion potential prior to an oncoming storm. Dune erosion may be parameterized in terms of the elevation of the total water level (composed of surge, tide, and wave runup) above the dune base and period of exposure of the dune to...