Wildfires are increasing in frequency. One area of research interest centers on the pollutants within wildfire smoke, including but not limited to particulate matter and polycyclic aromatic hydrocarbons. These chemicals are associated with exacerbation of respiratory, cardiovascular, dermatological, reproductive, oncological, gastrointestinal, and infectious conditions. As wildfires becoming increasingly prevalent, it...
The frequency of devastating disasters has increased in the United States due to the presence of climate change. Human subject research is often conducted in these post-disaster areas to gain valuable data and insights. In recent years, discourse regarding the ethical nature of research conduct in these exposure areas has...
This study looked at the impacts of climate change on medicinal plants, and how these impacts are viewed and understood in the herbalism community. Two literature reviews were conducted, to look at each of these two ideas: the first was a review of peer-reviewed literature describing research on climate change...
Being human is often portrayed as desirable in fiction. Many fictional beings, particularly robots and androids, seek out being human as a goal. Although current robotics is not advanced enough for robots and androids to be deemed sentient, the world of fiction is quickly becoming reality. With the integration of...
The ocean provides many ecosystems services and yet humans have viewed the ocean as a black hole for trash since the 1950s. With recycling not getting to the source of the problem, smarter consumer choices are being targeted, specifically choices centered around the use of plastic. Thus efficient, useful communication...
In the face of limited resources, how should those resources be allocated? The COVID-19 pandemic highlighted the difficulty of allocating a limited number of vaccines. The Centers for Disease Control and Prevention (CDC) issued standard guidelines based on ethical principles, yet all 50 states in the United States (US) interpreted...
We are constantly updating our research in the growing field of Environmental Health, yet we do not always translate this information in a way which is understood by the general public. This has resulted in tools which gauge the public’s understanding of health information, such as the eHEALS tool. This...
The Community Engagement Core of OSU's Superfund Research Program aims to increase cultural capacity among university scientists while simultaneously supporting research focused on reducing health disparities for Pacific Northwest Tribes originating from harmful chemical exposures in the environment.
The aryl hydrocarbon receptor (AhR) has recently been described as a novel therapeutic target, given the potent suppression of multiple immune-mediated diseases following activation by the prototypic ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In the parent-into-F1 graft-versus-host (GVH) model, suppression of the cytotoxic T-lymphocyte (CTL) response is associated with the presence of CD25⁺CTLA-4⁺IL-10⁺Foxp3[superscript...
The demands of the healthcare system on its employees are heavy and intense. Long working hours, high-stress environments, and emotionally exhausting situations can lead to burnout. This is particularly a constant concern in emergency medicine. Burnout has been associated with impacting well-being and performance. There is also an interest in...
_____________________________________________________________________
DianaRohlman, Committee Member, representing College of Public Health and Human
Sciences
According to a 2017 Pew Research Study, 44% of adults in America say that they do not feel informed enough about science to understand news and new discoveries discussed on the media (Funk et al. 2019). This is concerning, because adults are not just passive consumers of media; among other...
Emerging data showing the presence of atmospheric microplastics (MPs) has recently raised awareness surrounding the potential of human nanoplastics (NPs) exposure. Due to factors such as weathering, UV exposure, and other biodegradation processes, plastic pollution in the environment breaks down over time into micro (<5 micrometers) and nanoscale (<1000nm) particles....
Scytalidium ganodermophthorum (Xylogone ganodermophthora) is known as a yellow-pigmenting spalting fungus. However, recent observations have indicated that the dichloromethane-extracted pigment produced by S. ganodermophthorum can vary in color from yellow to green to red to purple, depending on the age of the fungus at harvesting. The timeline and mechanisms behind...
_____________________________________________________________________
DianaRohlman, Committee Member, representing College of Public Health and Human Sciences
Community-Engaged Research (CEnR) is a strategy for integrating community needs, priorities, and concerns into the research design, data collection strategies, and subsequent analysis of data. CEnR shares similar properties with both citizen science and community-based participatory research (Woolley et al., 2016). Before the COVID-19 pandemic, CEnR occurred predominantly via face-to-face...
Exposure assessment is necessary to determine the frequency and magnitude of environmental contaminants, especially since exposure may lead to adverse health outcomes. Traditional personal exposure assessment tools such as biological samples are limited in their ability to capture a wide range of chemical exposures from a single sample, and others...
The field of toxicology is challenged with a vast number of environmental chemicals and mixtures to which humans and ecosystems are exposed with limited toxicity data available. Chemical hazard assessment traditionally utilizes mammalian models and can be both cost- and time-limiting and may pose ethical concerns. To rapidly tackle this...
One expectation of community-based participatory research (CBPR) is participant access to study results. However, reporting experimental data produced by studies involving biological measurements in the absence of clinical relevance can be challenging to scientists and participants. We applied best practices in data sharing to report the results of a study...
Full Text:
study following consumption of traditionally
smoked salmon
Authors:
DianaRohlman
1,2
, Greta
One expectation of community-based participatory research (CBPR) is participant access to study results. However, reporting experimental data produced by studies involving biological measurements in the absence of clinical relevance can be challenging to scientists and participants. We applied best practices in data sharing to report the results of a study...
One expectation of community-based participatory research (CBPR) is participant access to study results. However, reporting experimental data produced by studies involving biological measurements in the absence of clinical relevance can be challenging to scientists and participants. We applied best practices in data sharing to report the results of a study...
One expectation of community-based participatory research (CBPR) is participant access to study results. However, reporting experimental data produced by studies involving biological measurements in the absence of clinical relevance can be challenging to scientists and participants. We applied best practices in data sharing to report the results of a study...
In west Eugene (Oregon), community research indicates residents are disproportionately exposed to industrial air pollution and exhibit increased asthma incidence. In Carroll County (Ohio), recent increases in unconventional natural gas drilling sparked air quality concerns. These community concerns led to the development of a prototype mobile device to measure personal...
Few studies have been published on the excretion rates of parent polycyclic aromatic hydrocarbons (PAHs) and hydroxy-polycyclic aromatic hydrocarbons (OH-PAHs) following oral exposure. This study investigated metabolism and excretion rates of 4 parent PAHs and 10 OH-PAHs after the consumption of smoked salmon. Nine members of the Confederated Tribes of...
Full Text:
., Santiago-Delgado, L., Rohlman, D., Schrlau, J. E., Harper, B.,
Harris, S., ... & Simonich, S. L. M. (2015
Few studies have been published on the excretion rates of parent polycyclic aromatic hydrocarbons (PAHs) and hydroxy-polycyclic aromatic hydrocarbons (OH-PAHs) following oral exposure. This study investigated metabolism and excretion rates of 4 parent PAHs and 10 OH-PAHs after the consumption of smoked salmon. Nine members of the Confederated Tribes of...
Full Text:
in Native Americans
Oleksii Motorykin1, Lisandra Santiago-Delgado1, Diana Rholman2, Jill E
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that plays multiple roles in regulation of immune and inflammatory responses. The ability of certain AhR ligands to induce regulatory T cells (Tregs) has generated interest in developing AhR ligands for therapeutic treatment of immune-mediated diseases. To this end, we...
Full Text:
Pennington1,
Diana Rohlman1, Edmond O’Donnell1, Patrick L. Iversen1, Siva Kumar Kolluri1,2, Nancy I
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that plays multiple roles in regulation of immune and inflammatory responses. The ability of certain AhR ligands to induce regulatory T cells (Tregs) has generated interest in developing AhR ligands for therapeutic treatment of immune-mediated diseases. To this end, we...
Few studies have been published on the excretion rates of parent polycyclic aromatic hydrocarbons (PAHs) and hydroxy-polycyclic aromatic hydrocarbons (OH-PAHs) following oral exposure. This study investigated metabolism and excretion rates of 4 parent PAHs and 10 OH-PAHs after the consumption of smoked salmon. Nine members of the Confederated Tribes of...
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that plays multiple roles in regulation of immune and inflammatory responses. The ability of certain AhR ligands to induce regulatory T cells (Tregs) has generated interest in developing AhR ligands for therapeutic treatment of immune-mediated diseases. To this end, we...
Drought can have substantial negative effects on human health, creating challenges for public health departments, emergency managers, and healthcare providers. For example, drought can lead to decreased water quantity and quality, increased incidence of illness or disease, increased mortality rates, and adverse mental health outcomes, especially as livelihoods are affected....
Consistent with its charge under Oregon House Bill 3543, the Oregon Climate Change Research Institute (OCCRI) conducts a biennial assessment of the state of climate change science, including biological, physical, and social science, as it relates to Oregon and the likely effects of climate change on Oregon. This sixth Oregon...
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a potent immunosuppressant and a prototypic ligand for the aryl hydrocarbon receptor (AhR). In a graft versus host (GvH) response, treatment with TCDD suppresses a cytotoxic T-lymphocyte (CTL) response by Day 10, concurrent with a T-regulatory (Treg) like phenotype in the donor CD4+ T-cells, observed on Day...
Full Text:
EXPERIMENTATION
61
Thanks to Dr. Nancy
Kerkvliet, DianaRohlman, Kerkvliet lab,
the *EHSC Flow
Cytometry
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a potent immunosuppressant and a prototypic ligand for the aryl hydrocarbon receptor (AhR). In a graft versus host (GvH) response, treatment with TCDD suppresses a cytotoxic T-lymphocyte (CTL) response by Day 10, concurrent with a T-regulatory (Treg) like phenotype in the donor CD4+ T-cells, observed on Day...
Full Text:
Acknowledgements
Thanks to Dr. Nancy Kerkvliet, DianaRohlman, the Kerkvliet lab, Dr. Malcolm Lowry, the
Silicone wristbands are easy-to-wear passive samplers that have been readily adapted into environmental health studies since first reported in 2014. Wristbands can be worn during normal daily activities and sequester a wide range of bioavailable organic chemicals. This dissertation includes a thorough review of silicone wristband technology, as well as...
I was honored to be the keynote speaker at the 30th Annual Society of Toxicologic Pathology Symposium “Toxicologic Pathology and the Immune System.” I had the opportunity to reminisce about events in the 1970s that set the stage for the birth and subsequent growth of the field of immunotoxicology and...
Silicone wristbands are passive sampling devices (PSD) that sequester bioavailable organic chemicals in the environment. In environmental health studies, silicone wristbands are easy to wear and can provide personal exposure data about complex chemical mixtures. This dissertation includes an overview of PSD technology, a literature review of current wristband research...
Natural gas extraction, often referred to as “fracking,” has increased rapidly in the U.S. in recent years. To address potential health impacts, passive air samplers were deployed in a rural community heavily affected by the natural gas boom. Samplers were analyzed for 62 polycyclic aromatic hydrocarbons (PAHs). Results were grouped...
Full Text:
FSES Program for help with analysis. Thank you to Dr. DianaRohlman of the OSU 393
Environmental
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is an important regulator of immune responses in various disease models. In the non-obese diabetic (NOD) mouse model of type 1 diabetes, activation of this receptor leads to suppression of the autoimmune response and limits immune cell infiltration of...
There are many links between exposure to environmental pollution and risks to human health. While advances in the fields of toxicology, exposure science, and environmental chemistry have shown light on many of these links, many more research challenges remain. One major challenge is how to accurately characterize the toxicity of...
Passive sampling is a popular technology for environmental monitoring, and silicone is an ideal choice for a variety of passive sampling applications. The silicone work described here encompasses laboratory and field studies that demonstrate the use of this polymer in novel environments, for new applications, and for emerging compounds. Unique...
In recent decades, there has been increased attention on human exposure to, and subsequently toxicity of, Polycyclic Aromatic Hydrocarbons (PAHs). PAHs are widespread organic pollutants and some have been shown to be toxic, carcinogenic and mutagenic. This research was focused on understanding the link between global PAH emissions and lung...
Climate change is causing people around the world to experience extreme temperature and air pollution events such as wildfires more frequently, and for longer periods of time. Extreme heat events have been widely associated with an increased risk of emergency room visits, occupational heat-related injuries and illnesses, and mortality overall...
(Polycyclic aromatic hydrocarbons) PAHs are widespread in the environment, and are derived from both natural and anthropogenic sources. The physicochemical properties of PAHs along with the wide range of PAH sources leads to their persistence in the environment. Since PAHs are ubiquitous, and have the potential to illicit adverse effects,...
Throughout their lifetime individuals are exposed to complex mixtures of chemicals. The study of chemical mixtures is an internationally recognized research priority, but seemingly complex challenge. To reduce the intricacy of studying mixtures, researchers have identified different prioritization methods based on exposure or the toxicity of chemicals. However, understanding the...
In the environment, it is the unbound fraction of chemical (Cfree) which is able to diffuse across environmental interfaces and biological membranes. It is therefore Cfree which drives many important biological-environmental processes including contaminant transport, bioaccumulation and toxicity. Passive sampling devices (PSDs) offer a simplified and more accurate approach for...
The immune toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been studied for over 35 years, but only recently has the profound immune suppression associated with TCDD exposure been linked to induction of regulatory T cells (Tregs). The effects of TCDD are mediated through binding the aryl hydrocarbon receptor (AhR), a ligand-activated transcription...
The agricultural lands of Saudi Arabia cannot support feeding the population since they have been facing environmental problems including climate change and water scarcity (DeNicola et al. 2015). Food security is the issue, especially in desert countries which rely on natural water resources. Saudi Arabia is one of these desert...
Wastewater epidemiology is an emerging discipline that requires collaborative research involving analytical chemists, drug epidemiologists, and wastewater engineers. Wastewater epidemiology involves the sampling and quantitative analysis of raw wastewaters from communities for illicit drugs and their metabolites. Mass loads (mass per day) and per capita (mg per day per person)...