Background: High birthweight is an established risk factor for childhood leukaemia.
Its association with other childhood cancers is less clear, with studies hampered by low
case numbers. Methods: We used two large independent datasets to explore risk associations between
birthweight and all subtypes of childhood cancer. Data for 16 554...
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International Journal of Epidemiology, 2015, 153–168
doi: 10.1093/ije/dyu265
Advance Access Publication Date
ABSTRACT
Eukaryotes produce functionally diverse classes of
small RNAs (20–25 nt). These include microRNAs
(miRNAs), which act as regulatory factors during
growth and development, and short-interfering
RNAs (siRNAs), which function in several epigenetic
and post-transcriptional silencing systems. The
Arabidopsis Small RNA Project (ASRP) seeks to characterize
and functionally analyze the...
MOTIVATION: Estimation of bacterial community composition from
a high-throughput sequenced sample is an important task in
metagenomics applications. Since the sample sequence data
typically harbors reads of variable lengths and different levels of
biological and technical noise, accurate statistical analysis of such
data is challenging. Currently popular estimation methods are...
Background: Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs) are synthetic DNA/RNA analogs that silence expression of specific genes. We studied whether PPMOs targeted to essential genes in Acinetobacter lwoffii and A. baumannii are active in vitro and in vivo. Methods: PPMOs were evaluated in vitro using MIC and viability assays, and in...
Antarctic krill are a key component of the diet of Adélie penguins inhabiting the Western Antarctic Peninsula (WAP), yet our understanding of the variability of krill distribution patterns within nearshore penguin feeding grounds is limited. A recent study of the foraging patterns of penguins breeding in the northern WAP suggests...
BACKGROUND: A substantial proportion of the general population has low lung function, and lung function is known to decrease as we age. Low lung function is a feature of several pulmonary disorders, such as uncontrolled asthma and chronic obstructive pulmonary disease (COPD). The objective of this study is to investigate...
Sharp increases in the use of flammable plastics and electronic devices coupled with stricter fire safety requirements have promoted the heavy use of flame retardant chemicals. While flame retardant use has increased, a great deal of uncertainty surrounds their safety with some evidence showing toxicity and risk to human and...
Most research on military service focuses on its short-term negative consequences, especially the mental and physical injuries of those deployed in warzones. However, studies of long-term outcomes reveal surprisingly positive effects of military service—both those early in adulthood that grow over time and others that can emerge later in life....
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56, Issue 1 of The Gerontologist, DOI: 10.1093/
geront/gnv093, the opening quotation was not