Toxoplasma gondii, the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, and is currently incurable. New, curative medicines are needed urgently. Herein, we develop novel models to facilitate drug development: EGS strain T. gondii forms cysts in vitro that induce oocysts in...
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refinement tools in
REFMAC5, (2012) ActacrystallographicaSectionD: Biologicalcrystallography
S92
Nanotechnology is of increasing significance. Curation of nanomaterial data into electronic databases offers opportunities to better understand and predict nanomaterials’ behaviour. This supports innovation in, and regulation of, nanotechnology. It is commonly understood that curated data need to be sufficiently complete and of sufficient quality to serve their intended purpose....
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Lynch,b Willie Peijnenburg,c,d John Rumble,e
Fred Klaessig,f Clarissa Marquardt,g Hubert Rauscher,h
Eukaryotic ribosome biogenesis involves ~200 assembly
factors, but how these contribute to ribosome
maturation is poorly understood. Here, we
identify a network of factors on the nascent 60S subunit
that actively remodels preribosome structure. At its hub is
Rsa4, a direct substrate of the force-generating ATPase
Rea1. We show that...
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Heidelberg University, INF328, D-69120 Heidelberg, Germany
2Centre for Synthetic and Systems Biology
Four new elaiophylin macrolides (1–4), together with five known elaiophylins (5–9), have been isolated from cultures of the Indonesian soil bacterium Streptomyces sp. ICBB 9297. The new compounds have macrocyclic skeletons distinct from those of the known dimeric elaiophylins in that one or both of the polyketide chains contain(s) an...
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.; Keller-Schierlein, W. Helv. Chim. Acta. 1981, 64, 407-424.
(17) Seebach, D.; Chow, H.-F.; Jackson, R. F
Molecular dynamics simulations, conventional and metadynamics, were performed to determine the interaction of model protein Gb1 over kaolinite (001), Na⁺-montmorillonite (001), Ca²⁺-montmorillonite (001), goethite (100), and Na⁺-birnessite (001) mineral surfaces. Gb1, a small (56 residue) protein with a well-characterized solution-state nuclear magnetic resonance (NMR) structure and having α-helix, 4-fold β-sheet,...
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biological and
natural organic matter (NOM) with mineral surfaces, involving
multiple techniques, such as