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Filtering by: Creator Al-Hammali, Hussain Y. Remove constraint Creator: Al-Hammali, Hussain Y. Date Unknown Remove constraint Date: Unknown

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  • KangYukiLPIHDAC8STAT3Repress_SupplementaryMaterials.zip

    Creator:
    Kang, Y., Nian, H., Rajendran, P., Löhr, C. V., Bisson, W. H., Williams, D. E., and et al.
    Abstract:
    Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...

  • KangYukiLPIHDAC8STAT3Repress.pdf

    Creator:
    Kang, Y., Nian, H., Rajendran, P., Löhr, C. V., Bisson, W. H., Williams, D. E., and et al.
    Abstract:
    Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
    Full Text:
    representative findings from two or more independent experiments HDAC8 repression of BMF Y Kang et al 2 Cell