The dipyridophenazine (dppz) based ruthenium polypyridyl complexes are known as molecular ‘light-switches’ for DNA. This property is poised to serve in diagnostic and therapeutic applications, but the poor cellular uptake restricts their use in live cells. Herein, we show that the cellular uptake, and more interestingly and surprisingly, the nuclear...
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references,1-3 [Ru(bpy)3]2+Cl2 and
5 [Ru(phen)3]2+Cl2 were purchased from Sigma-Aldrich. Pentachlorophenol
Zinc oxide nanoparticles (ZnO NPs) are widely used in a variety of products, thus understanding their health and environmental impacts is necessary to appropriately manage their risks. To keep pace with the rapid increase in products utilizing engineered ZnO NPs, rapid in silico toxicity test methods based on knowledge of...
A selective and label-free biosensor for detection of the explosive compound 2,4,6-trinitrotoluene (TNT) in aqueous solution was developed based on the principle of photoluminescence quenching of upon immunocomplex formation with antibody-functionalized diatom frustule biosilica. The diatom frustule is an intricately nanostructured, highly porous biogenic silica material derived from the shells...
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an anti-TNT monoclonal antibody fragment
Le Zhena, Nicole Fordb, Debra K. Galea, Guritno
Joseph Reddeford Walker conducted
a party of men across the Sierra Nevada to the
Pacific coast of California in 1833. Previous
interpretations of the portion of the route
from Humboldt Sink, Nevada, to the San Joaquin
River, California, are not satisfactory. A
body of descriptions of the terrain traversed
exists...
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, [phydra hians,
existed (they no longer exist in Mono Lake44) in these lakes
was confirmed by Aldrich
Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chinese with a sample size 2.7 times the...
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profiling of 900,015 SNPs per sample, including 600 k SNPs of common variants (MAF ≥ 5%),
290 k SNPs of
Self-assembly of recombinant proteins within the biosilica of living diatoms represents a means to construct functional materials in a reproducible and scalable manner that will enable applications that harness the inherent specificities of proteins to sense and respond to environmental cues. Here we describe the use of a silaffin-derived lysine-rich...
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-sulfonic acid (Sigma-Aldrich) to either Alexa Fluor 488 cadaverine or Alexa Fluor 555
cadaverine (Life
The Peck Mountain area is located in west-central Idaho just 15 miles east of the Oregon-Idaho border. It is tectonically located within the "Columbia Arc" of the Nevadan oroaenic belt. The Seven Devils Volcanics, Permian to Traissic in age, are the oldest rocks in the area. They are composed of...
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'' rt .
i ,
i o.
'- . s' 'k
Figure 9. Photomicrograph of quartz keratophyre
15
quartz
The global terrestrial carbon sink offsets one-third of the world’s fossil fuel emissions, but the strength of this sink is highly sensitive to large-scale extreme events. In 2012, the contiguous United States experienced exceptionally warm temperatures and the most severe drought since the Dust Bowl era of the 1930s, resulting...
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Isotope
Research, University of Groningen, 9747 AG Groningen, The Netherlands
Edited by Susan E. Trumbore