Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
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,2 Cary Bauer,3 Jeffrey A. Bell,4 Helen M. Berman,5,6 Talapady N. Bhat,7
Jeff M. Blaney,8 Evan
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
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Workshop
Paul D. Adams, Kathleen Aertgeerts, Cary Bauer, Jeffrey A. Bell, Helen M.
Berman, Talapady N
This study investigated terminal and instrumental value
priorities of students in various majors within an academic
department. The investigator tested a sample of 99
volunteers of both sexes from several classes in the
department of Speech Communication at a major land grant
university by use of the Rokeach Value Survey....
BACKGROUND: The objective of this study was to identify associations between the concentration of Mycobacterium avium subsp. paratuberculosis (MAP) antibodies in bulk milk and potential risk factors in herd management and herd characteristics, explaining high MAP antibody titers in milk. An extensive questionnaire was administered to 292 organic and conventional...
Ageism in the context of global population aging could lead to increasing human and economic costs. Age stereotypes tend to be negative (Hummert, 1990) and ubiquitous (Nelson, 2002) there are a variety of well documented detrimental consequences of negative age stereotypes on older adults' physical, cognitive and psychological outcomes (Hummert,...
Psychological theory of social cognition and Buddhist philosophy of cognition suggest that people's actions should determine their impressions of future events. In psychology, several studies have shown that behavior can activate constructs and thereby influence one's perception. However, they do not address prosocial behavior, a specific concern of Buddhist philosophy...
This study uses derivative spectroscopy to assess qualitative and quantitative information regarding seafloor types that can be extracted from hyperspectral remote sensing reflectance signals. Carbonate sediments with variable concentrations of microbial pigments were used as a model system. Reflectance signals measured directly over sediment bottoms were compared with remotely sensed...
A spectrum-matching and look-up-table (LUT) methodology has been developed and evaluated to extract environmental information from remotely sensed hyperspectral imagery. The LUT methodology works as follows. First, a database of remote-sensing reflectance (R[subscript]rs) spectra corresponding to various water depths, bottom reflectance spectra, and water-column inherent optical properties (IOPs) is constructed...
An Expert Panel convened by the National Lipid Association previously developed a consensus set of recommendations for the patient-centered management of dyslipidemia in clinical medicine (part 1). These were guided by the principle that reducing elevated levels of atherogenic cholesterol (non–high-density lipoprotein cholesterol and low-density lipoprotein cholesterol) reduces the risk...
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, Ralph La Forge, MSc,
Stephen R. Daniels, MD, PhD, Don P. Wilson, MD, Pamela B. Morris, MD,
Robert A
An Expert Panel convened by the National Lipid Association previously developed a consensus set of recommendations for the patient-centered management of dyslipidemia in clinical medicine (part 1). These were guided by the principle that reducing elevated levels of atherogenic cholesterol (non–high-density lipoprotein cholesterol and low-density lipoprotein cholesterol) reduces the risk...