Pactamycin, a complex aminocyclitol compound produced by Streptomyces pactum, has significant antibiotic, antitumor, and antiplasmodial activity. However, this natural product has not been developed for clinical use due to its high cytotoxicity. Modulation of its biological properties by chemical synthesis has been difficult due to its complex chemical structure. Therefore,...
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Biosynthesis
Andrew Osborn
Research Mentors: Dr. Taifo Mahmud, Dr. Kerry McPhail
A Bioresource
Pactamycin, a complex aminocyclitol compound produced by Streptomyces pactum, has significant antibiotic, antitumor, and antiplasmodial activity. However, this natural product has not been developed for clinical use due to its high cytotoxicity. Modulation of its biological properties by chemical synthesis has been difficult due to its complex chemical structure. Therefore,...
Full Text:
By
Andrew Osborn
An Undergraduate Thesis Submitted to
Oregon State University
Chitosan based hemorrhage control dressings provide effective external hemorrhage control while having few side effects. Known residual contaminants present in chitosan formulations include endotoxins and proteins known to stimulate gene expression in the liver. This study investigated gene expression in the liver using rat bio-compatibility models to gain knowledge regarding...
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Based Hemostatic Control Patch in Rat Models
By
Andrew J. Colburn
A thesis submitted to
Oregon
Chitosan based hemorrhage control dressings provide effective external hemorrhage control while having few side effects. Known residual contaminants present in chitosan formulations include endotoxins and proteins known to stimulate gene expression in the liver. This study investigated gene expression in the liver using rat bio-compatibility models to gain knowledge regarding...
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Subcutaneous Chitosan Patch Formulations
Andrew Colburn1, Leslie Dyal, Ph.D.2 and John Mata Ph.D.2
Oregon
A wilderness area, as administered by the U. S. Forest Service, is a tract of undeveloped land over 100,000 acres in size with no roads or provision for motorized transportation. Commercial timber cutting, hotels, stores, and similar developments are prohibited. While there are some exceptions for private holdings and administrative...
A wilderness area, as administered by the U. S. Forest Service, is a tract of undeveloped land over 100,000 acres in size with no roads or provision for motorized transportation. Commercial timber cutting, hotels, stores, and similar developments are prohibited. While there are some exceptions for private holdings and administrative...
A wilderness area, as administered by the U. S. Forest Service, is a tract of undeveloped land over 100,000 acres in size with no roads or provision for motorized transportation. Commercial timber cutting, hotels, stores, and similar developments are prohibited. While there are some exceptions for private holdings and administrative...
Mammalian cysteine dioxygenase (CDO) is a mononuclear non-heme iron protein that catalyzes 2 the conversion of cysteine (Cys) to cysteine sulfinic acid (CSA) by an unclarified mechanism. 3 One structural study revealed a Cys-persulfenate (or Cys-persulfenic acid) formed in the active 4 site, but quantum mechanical calculations have been used...
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, Lawrence L. Hirschberger
d
, 4
Martha H. Stipanuk
d*
, and P. Andrew Karplus
a*
5
6
a
Mammalian cysteine dioxygenase (CDO) is a mononuclear non-heme iron protein that catalyzes 2 the conversion of cysteine (Cys) to cysteine sulfinic acid (CSA) by an unclarified mechanism. 3 One structural study revealed a Cys-persulfenate (or Cys-persulfenic acid) formed in the active 4 site, but quantum mechanical calculations have been used...
Full Text:
is weaker than that of the Cys93 Sγ, consistent with the iron having 5
decreased occupancy. We
Suicide is a leading cause of death amongst adolescents, and transgender and gender diverse youth are at especially high risk for suicidal ideation and attempt compared with cisgender peers. Using established ideation-to-action models of suicide and the Minority Stress Model, this project used the 2019 results of the Oregon Healthy...
