A promising formulation of glipizide comprising compression of four-layer coated beads into tablets which has advantages of providing a lag time (~ 2 hours) before drug release, retaining sustained-release characteristics, and providing approximately zero-order drug release, with drug release nearly independent of paddle speeds of 50 and 100 rpm during...
A promising formulation of glipizide comprising compression of four-layer coated beads into tablets which has advantages of providing a lag time (~ 2 hours) before drug release, retaining sustained-release characteristics, and providing approximately zero-order drug release, with drug release nearly independent of paddle speeds of 50 and 100 rpm during...
A promising formulation of glipizide comprising compression of four-layer coated beads into tablets which has advantages of providing a lag time (~ 2 hours) before drug release, retaining sustained-release characteristics, and providing approximately zero-order drug release, with drug release nearly independent of paddle speeds of 50 and 100 rpm during...
The origin of the late pre-industrial Holocene (LPIH) increase in atmospheric methane concentrations has been much debated. Hypotheses invoking changes in solely anthropogenic sources or solely natural sources have been proposed to explain the increase in concentrations. Here two high-resolution, high-precision ice core methane concentration records from Greenland and Antarctica...
Full Text:
Anthropogenic Contribution to the
Atmospheric Methane Budget
Logan Mitchell,* Ed Brook, James E. Lee, Christo
The origin of the late pre-industrial Holocene (LPIH) increase in atmospheric methane concentrations has been much debated. Hypotheses invoking changes in solely anthropogenic sources or solely natural sources have been proposed to explain the increase in concentrations. Here two high-resolution, high-precision ice core methane concentration records from Greenland and Antarctica...
The amino acid acridon-2-ylalanine (Acd) can be a valuable probe of protein conformational change because it is a
long lifetime, visible wavelength fluorophore that is small enough to be incorporated during ribosomal biosynthesis. Incorporation
of Acd into proteins expressed in E. coli requires efficient chemical synthesis to produce large quantities...
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Fluorescent Amino Acid for Lifetime and
FRET/LRET Studies
Lee C. Speight,† Anand K. Muthusamy,† Jacob M
The amino acid acridon-2-ylalanine (Acd) can be a valuable probe of protein conformational change because it is a
long lifetime, visible wavelength fluorophore that is small enough to be incorporated during ribosomal biosynthesis. Incorporation
of Acd into proteins expressed in E. coli requires efficient chemical synthesis to produce large quantities...
Full Text:
FRET/LRET Studies
Lee C. Speight,† Anand K. Muthusamy,† Jacob M. Goldberg,† John B. Warner,† Rebecca
We used metatranscriptomics to study the gene transcription patterns of microbial plankton (0.2 to 64 μm) at a mesohaline station
in the Chesapeake Bay under transitions from oxic to anoxic waters in spring and from anoxic to oxic waters in autumn.
Samples were collected from surface (i.e., above pycnocline) waters...
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Bay during
Oxic-Anoxic-Oxic Transitions
Hewson, I., Eggleston, E. M., Doherty, M., Lee, D. Y., Owens
We used metatranscriptomics to study the gene transcription patterns of microbial plankton (0.2 to 64 μm) at a mesohaline station
in the Chesapeake Bay under transitions from oxic to anoxic waters in spring and from anoxic to oxic waters in autumn.
Samples were collected from surface (i.e., above pycnocline) waters...
Lateral stirring is a basic oceanographic phenomenon affecting the distribution of physical, chemical, and biological fields. Eddy stirring at scales on the order of 100 km (the mesoscale) is fairly well understood and explicitly represented in modern eddy-resolving numerical models of global ocean circulation. The same cannot be said for...