The antimutagenic potency of wheat grain and berry extracts was studied in vitro against several heterocyclic amines (HCAs) using the Salmonella mutagenicity assay and the anticarcinogencity of wheat grain was studied in vivo using the rat colonic aberrant crypt focus assay. Wheat bran, which binds HCAs in vitro, as well...
Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), a primary I3C
derivative in vivo, are known chemopreventive agents available as dietary supplements.
I3C was found to suppress or enhance tumors in several animal models.
Chemoprotection is attributed to the ability of indoles to alter carcinogen metabolism
effectively blocking initiation. However, mechanisms for enhancement...
Identifying appropriate units for conservation requires knowledge of evolutionary
patterns and risks of managing at different geographical and genetic scales. I examined
genetic diversity at different geographical scales among 11,400 rainbow trout
(Oncorhynchus mykiss) from 243 locations in 13 major river basins throughout much of
their range and among coho...
Two-year chemistry-based technology training (CBTT) programs in the U.S. are important in the preparation of the professional technical workforce. The purpose of this study was to identify, examine, and analyze factors related to the economic sustainability of CBTT programs. A review of literature identified four clustered categories of 31 sub-factors...
Genomic analysis is a new approach for the characterization and investigation of novel genes, gene clusters, the function of uncharacterized proteins, and genetic diversity in microorganisms. These approaches are important for the study of chlamydiae, a system in which several genomes have been sequenced but in which techniques for genetic...
Indole-3-carbinol (I3C), the most abundant metabolite of glucobrassicins, is
found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and
cauliflower. I3C has been shown to have anticarcinogenic activity against many
chemical carcinogens in multiple target organs in animal models. However, the
anticarcinogenic activity of I3C is considered indirect since...
Lymphomas and leukemias are the most common cancer in children and young adults and in utero exposure to carcinogens may contribute to the etiology of these cancers. A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), was administered to pregnant mice (15 mg/Kg b.w., gavage) on gestation day 17. Significant mortalities in...