Glutathione, a ubiquitous intracellular tripeptide, protects cells by reacting with electrophiles and radicals that can damage cellular macromolecules. However, glutathione conjugation is now recognized as one mechanism by which drugs and xenobiotics can also be converted to reactive intermediates having toxic consequences to cells. The halogenated alkane 1,2-dichloroethane forms S-(2-chloroethyl)...
Miombo woodland and dambo grassland soils were selected to study the effect of soil transfer on early growth of B. petersiana, C. spectabilis, and C. calothyrsus on degraded sites in northern Zambia. The experiment was conducted on previously slash and burned, cultivated, and abandoned sites. Both sterile and unsterile miombo...
The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on hepatic
pyruvate carboxylase (PC) gene expression were investigated in C57BL/6J Ah[superscipt b/b male
mice. A dose-dependent reduction of PC levels and activity occurred in animals given a
single intraperitoneal dose of TCDD in a corn oil carrier. The dose ranged from 1 to...
In the first experiment the minimum dietary toxic levels of vitamin A were determined in pregnant rabbits over three parities. The treatments consisted of basal diet plus 10,000, 30,000, 60,000, and 90,000 IU/Kg added vitamin A. The basal diet was formulated to be free of vitamin A and beta-carotene; rice...
Non-vascularized hearts of buffalo sculpin (Enophrys bison)
were used to investigate the cardiac toxicity of compounds that
cause methemoglobinemia. The affinity of sculpin cardiac myoglobin
for oxygen (P50 = 1.10 torr at 20 C°, pH 7.8) was lower than that of
mammals studied (P50 = .44 and .76 torr for...
A partially automated radio-tracking system with semi-continuous
azimuth data collection and XYLOG5 and MAP computer programs for azimuth
data analysis was used for studies of California quail (Callipepla
californica) at the E.E. Wilson Wildlife Area, Oregon, in 1988 and 1989.
Movements of 58 hens were monitored daily to determine nest...
