Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
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Cao et al.
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
Understanding magmatic processes occurring at depth in magmatic systems is fundamental for a more complete understanding of the variations sampled in lavas erupted from these systems on the Earth's surface. This thesis presents the results of detailed trace element analyses of plagioclase and clinopyroxene phenocrysts measured by laser ablation-inductively coupled...
This study focuses in providing the knowledge on carbon (C) stocks, emission and ecosystem productivity related to land use/land cover change in tropical peatlands. The field research activities were conducted for about 17 months between August 2013 to December 2015, at Pematang Gadung peat dome (peat depth up to 10.5...
Understanding complex traits is a fundamental challenge in plant genetics and a prerequisite for molecular breeding. Tools for trait dissection are markers, maps, and quantitative trait locus (QTL) analysis. Marker-assisted selection (MAS) is an application that integrates these tools. In this thesis research, a new sequence-based marker was evaluated, maps...
Labeling videos is costly, time-consuming and tedious. These costs can escalate in applications such as medical diagnosis or autonomous driving where we need domain expertise for annotation. Few-shot action recognition aims to solve this problem by annotation-efficient learning mechanisms.
This thesis presents MetaUVFS as the first Unsupervised Meta-learning algorithm for...
The importance of two sources of NO formation, nitrogen in combustion air
and nitrogen in the fuel, during black liquor combustion was studied using a laminar
entrained flow reactor. Pyrolysis and combustion experiments were conducted in
nitrogen atmosphere and in a mixture of argon and helium in the composition 99%...
This paper addresses the high model complexity and overconfident frame labeling of state-of-the-art (SOTA) action segmenters. Their complexity is typically justified by the need to sequentially refine action segmentation through multiple stages of a deep architecture. However, this multistage refinement does not take into account uncertainty of frame labeling predicted...