An expedient approach to the synthesis of a wide range of highly programmable biaryl templates has been accomplished. Utilizing the Diels-Alder [4+2] cycloaddition, a wide range of tri- and tetra-ortho-substituted biaryls have been synthesized in only three to four steps from commercially available materials. We have successfully synthesized entire classes...
Lycopodium alkaloids have shown widespread and noteworthy biological activity, consisting of over 250 known natural products. Moreover, their structural complexity and diversity have attracted considerable attention from numerous laboratories including our own. Recently, we have developed a unified approach that would provides access to numerous, previously unprepared C₁₀-functionalized lycopodium alkaloids....
The relationship between pea enation mosaic virus
(PEMV) and aging pea aphids was studied. Although this
research initially emphasized the relationship between the
decline in the rate of PEMV transmission and the 'concentration
of PEMV within pea aphids, aphid age was found to be
the principle factor influencing transmission. Enzymelinked...
The work described herein details the synthesis and application of
biphenyls that probe the effects of hydrogen, Cl / Br, and methyl substituents
on the aryl ring of the terminal acetylenic carbon. From this work, we
successfully developed the rapid synthesis of phenyl acetylenes in 3-4 steps
from inexpensive commercially...
Effective methods for the enantiopure formation of substituted piperidine rings are significantly important due to their presence in alkaloid products. A valuable method to form these ring systems would be via an intramolecular heteroatom Michael addition from the corresponding enone or enal. Described herein is a methodolgy that has been...
The transmission of strawberry mottle virus (SMV) to Fragaria vesca
L. by Chaetosiphon thomasi and C. fragaefolii was studied to determine
differences between the two species. Acquisition, inoculation, and
retention phases of transmission were described. In all phases, C.
fragaefolii was found to be the more efficient vector.
Mean transmission...
The enantioselective total synthesis of quinolizidine-containing natural product cermizine D and formal syntheses of senepodine G and cermizine C has been achieved. These natural products are members of the lycopodium alkaloids, which have attracted significant attention due to their exciting biological activities and the diverse structural scaffolds. Key steps in...
Two types of exogenous mortality factors, density-independent and density-dependent, were identified for the black vine weevil, Otiorhynchus sulcatus Fab., developing on container grown rhododendrons. The addition of the insecticide acephate, (O.S.- Dimethyl acetylphosphoramidothioate, Orthene®)75S) to the rhizosphere of rhododendrons in which larval O. sulcatus develop was categorized as a density-independent...
A Diels-Alder approach to biaryls (DAB) has been applied towards the synthesis
of highly substituted, programmable biaryl templates. Tri- and tetra-ortho-substituted
biaryls can be produced in just three to four steps from commercially available materials
utilizing the Diels-Alder [4+2] cycloaddition. The methods described herein will
illustrate the ability of mono...
Lycopodium alkaloids have generated enormous amounts of interest from the scientific community, both as synthetic targets and for their medicinal properties. Herein is described work towards a unifying approach to large segments of the Lycopodium family. An organocatalyzed intramolecular heteroatom Michael reaction method, for the construction of piperidine and piperizine...