Rapamycin (Rapa) and dietary restriction (DR) have consistently
been shown to increase lifespan. To investigate whether Rapa
and DR affect similar pathways in mice, we compared the effects
of feeding mice ad libitum (AL), Rapa, DR, or a combination of
Rapa and DR (Rapa + DR) on the transcriptome and...
Full Text:
UTHSCSA LAR for mouse
husbandry, Greg Friesenhahn for rapamycin measurements, and Caro-
lina Livi and
The existence of the ethnic "barrios" (ghettos) across American society is proof of the legacy of racism, injustice and inequality in society today. In this thesis, the human experiences of Native, African, Mexican, and Asian people, are presented to contradict the notion that the "American Dream" is for all. In...
This thesis describes in-vitro and in-vivo evaluation of a transdermal atenolol formulation developed at Oregon State University, College of Pharmacy. The formulation was prepared from carbomer as a gel base with propylene glycol, glycerol, ethanol, polysorbate 80 and dimethyl-isosorbide (DMI) as mixture of penetration enhancing agents. The effect of the...
BCL11B is a transcriptional regulatory protein that plays essential roles during mouse embryonic development. BCL11B is expressed and functions in the immune and nervous systems as well as within ectodermal organs. Multiple studies have characterized the roles of BCL11B in T cells, brain, and skin. However, very little is known...
Ecosystems are facing increasing threats from human related activities, such as overfishing, pollution, habitat destruction, species invasions, and diseases, among others. While oceanic islands provide natural laboratories to understand ecological and evolutionary process, they are also particularly vulnerable to these impacts, given their usual isolation from the mainland and the...
Culture, thought worldview and language have been
discussed for a long time in different fields from various
perspectives. However, the basis of this study is the view
of language as both the product and producer of people just
as people are the producer and product of language. Each
language requires...
A gene-ecological transplant study was made on populations of
the Crepis nana and C. elegans complex from the Arctic and Alpine of
North America. Transplants were collected from the Brooks Range,
Eagle Summit, and Alaska Range in Alaska, the Rocky Mountains in
Alberta, the Olympic Mountains in Washington, the Wallowa...
In this dissertation, I examine the process of building a Sámi food movement in northern Sweden. Using 15 months of ethnographic research that included observation of food events (n=100) and semi-structured interviews with food producers and activists (n=47), I describe how Sámi individuals are incorporating global food activism frameworks into...
Influenza A and Respiratory Syncytial Virus (RSV) are both enveloped, negative strand
RNA viruses which infect the respiratory mucosa of animals and humans. Despite
decades of research and development of antivirals and vaccines, both of these viruses
continue to be a major health concern throughout the world. The focus of...