The ethyl acetate extract of the culture filtrate of the marine Ascomycete,
Leptosphaeria oraemaris (Linder) yielded a novel metabolite
designated by the common name leptosphaerin. An x-ray crystallographic
structure analysis was disproved by the synthesis of 3-acetoxy-S-(1,2-dihydroxyethyl)-
3-pyrrolin-2-one 1, starting with N,N-dibenzylhydroxylamine
47 and D-mannitol 44. Oxidation of 47 followed...
A number of historians of science have been involved
in studying the nature of biology at the turn of the
century, and the picture that they have developed describes
biology during this time as a field struggling to define
itself. During the late nineteenth and early twentieth
centuries, biologists were...