Index Catalog // ScholarsArchive@OSU

Pharmacokinetic modeling and simulations of gastrointestinal transit effects on drug pharmacokinetics from enteric-coated pellet formulations and their applications

Creator:: Watanalumlerd, Prapoch
Abstract:: Effects of gastrointestinal transit on plasma concentrations of drugs from enteric-coated pellet formulations were demonstrated using pharmacokinetic models describing plasma concentrations of drugs from various enteric-coated pellet formulations. Gastric emptying time, lag time of emptying, and drug release rate from pellets in the small intestine, along with other pharmacokinetic parameters...
Resource Type:: Dissertation
Full Text:: Formulations 3) Development of Leaky Enteric-Coated Pellets Formulations Abstract James W. Effects of

Formulation studies of lactic acid-producing bacteria for oral administration

Creator:: Liou, Yow-Hwa Grace
Abstract:: Effects of lactobacilli in enteric coated capsules were studied in piglets (Chapter I). Lactobacillus acidophilus and Lactobacillus bulgaricus isolated from a commercial product were formulated in capsules, enteric coated, and then given to both Escherichia coli-challenged and unchallenged baby pigs. Decreased incidence and severity of diarrhea, and decreased weight deceleration...
Resource Type:: Dissertation
Full Text:: severity of diarrhea, and decreased weight deceleration showed that the enteric coated lactobacilli had

Novel formulation : development of oral microparticulate non-viral DNA vaccine delivery system against infectious hematopoetic necrosis virus (IHNV) in Rainbow Trout, statistical design in matrix tablets formulation

Creator:: Tantituvanont, Angkana
Abstract:: This dissertation describes two different projects. The first is the development of an oral DNA vaccine delivery system for fish. A novel oral DNA vaccine delivery system was developed for Rainbow Trout by combining non-viral vectors (polycationic liposomes or polycationic polymer) to facilitate the DNA vaccine's uptake by cell membranes...
Resource Type:: Dissertation
Full Text:: enteric-coated beads for oral pIIIINV-G 166 vaccine (Treatment 8) 4.8 Formulation of enteric-coated beads

Development of novel oral enteric-coated aquaculture vibrio vaccines

Creator:: Wong, George Kaon
Abstract:: An oral Vibrio vaccine for salmonids was developed. The vaccine was produced by spray coating lyophilized formalin-killed whole cells of Vibrio anguillarum (VA LS 1- 74) onto non-pareil sugar beads. Then methacrylic acrylic acid copolymer (Eudragit L-30D) was applied as an enteric protective coating. Using x-ray radiographic techniques, it was...
Resource Type:: Dissertation
Full Text:: Development of novel oral enteric-coated aquaculture

Tablet shapes and in vitro evaluation of coated hydrophilic matrix tablets novel mupirocin formulations non-acidic enteric coating of omeprazole and novel hot-melt coating process

Creator:: Leung, Manshiu
Abstract:: This dissertation is comprised of four distinct formulation sections, which are described below: A novel solid dosage formulation was investigated for achieving zero-order drug release profile by combining tablet shape design and tablet membrane film coating. Verapmail (model drug) was compressed into hydrophilic matrix tablet cores of flat-faced and bi-convex...
Resource Type:: Dissertation
Full Text:: Evaluation of Coated Hydrophilic Matrix Tablets; Novel Mupirocin Formulations; Non-Acidic Enteric Coating of

New acetaminophen products : formulation development and bioavailability

Creator:: Mansell, Libbie J.
Abstract:: Development of a novel, useful, orally administered dosage form providing controlled, sustained release of an active ingredient was desired. Film layers of Aquacoat and Eudragit L-30D (commercially available coating materials) were applied to acetaminophen cores. Amount of coating material, number of polymer layers, and order of application were varied. In...
Resource Type:: Dissertation
Full Text:: : FORMULATION DEVELOPMENT AND BIOAVAILABILITY GENERAL INTRODUCTION 1. STATEMENT OF THE PROBLEM The original

New product formulation and multiple dose pharmacokinetics of acetaminophen

Creator:: Sahajwalla, Chandrahas G.
Abstract:: Four different treatments of acetaminophen were administered to eight healthy volunteers in multiple doses (five doses). Saliva acetaminophen concentration-time profiles were determined. Non-compartmental pharmacokinetic parameters for the first and last dose were calculated and compared to determine whether acetaminophen exhibited linear or dose dependent pharmacokinetics. Dose corrected area under the...
Resource Type:: Dissertation
Full Text:: suspension was also investigated using coated pellets. These formulations were aged for a period of one year

New product formulations and pharmacokinetics of acetaminophen

Creator:: Borin, Marie T.
Resource Type:: Dissertation
Full Text:: formulation containing spray-coated acetaminophen pellets. In vitro dissolution of intact tablets containing

Bioadhesive polymers in drug product formulations

Creator:: Tavipatana, Wattanaporn
Abstract:: Gastric retention time of single unit dosage forms in swine was found to be much longer than in humans. It was concluded that swine are not a good animal model to study GI transit time of nonerodable or slowly eroded dosage forms. Noneradable and slowly eroded dosage forms used to...
Resource Type:: Dissertation
Full Text:: gastrointestinal transit time of coated magnesium hydroxide caplet. formulation: enteric coated 1.2 g magnesium

Development of novel spray coated soft elastic gelatin capsule sustained release formulations of nifedipine, bioavailability and bioequivalence of verapamil HCL controlled release formulations, pharmacokinetics of terbinafine after single oral doses in raptors

Creator:: Fahmy, Sahar Abd El-Sattar
Abstract:: This dissertation describes the development of a new sustained release formulation of nifedipine. The new formulation was developed by coating commercially available immediate release soft elastic gelatin capsules using a spray coating technique with two different polymeric combinations. Dissolution studies were conducted and showed that controlled release of nifedipine was...
Resource Type:: Dissertation
Full Text:: Reserved Development of Novel Spray Coated Soft Elastic Gelatin Capsule Sustained Release Formulations

ScholarsArchive@OSU

Pharmacokinetic modeling and simulations of gastrointestinal transit effects on drug pharmacokinetics from enteric-coated pellet formulations and their applications

Formulation studies of lactic acid-producing bacteria for oral administration

Novel formulation : development of oral microparticulate non-viral DNA vaccine delivery system against infectious hematopoetic necrosis virus (IHNV) in Rainbow Trout, statistical design in matrix tablets formulation

Development of novel oral enteric-coated aquaculture vibrio vaccines

Tablet shapes and in vitro evaluation of coated hydrophilic matrix tablets novel mupirocin formulations non-acidic enteric coating of omeprazole and novel hot-melt coating process

New acetaminophen products : formulation development and bioavailability

New product formulation and multiple dose pharmacokinetics of acetaminophen

New product formulations and pharmacokinetics of acetaminophen

Bioadhesive polymers in drug product formulations

Development of novel spray coated soft elastic gelatin capsule sustained release formulations of nifedipine, bioavailability and bioequivalence of verapamil HCL controlled release formulations, pharmacokinetics of terbinafine after single oral doses in raptors

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