Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms
linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family
members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
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, James C, Josefsson EC et al.
Deciphering the molecular and biological processes that mediate histone
The global terrestrial carbon sink offsets one-third of the world’s fossil fuel emissions, but the strength of this sink is highly sensitive to large-scale extreme events. In 2012, the contiguous United States experienced exceptionally warm temperatures and the most severe drought since the Dust Bowl era of the 1930s, resulting...
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. S2 and Table S1). Eddy-
covariance (EC) flux tower measurements are direct integrations of whole
Wood is a major pool of organic carbon that is highly resistant to decay, owing largely to the presence of lignin. The only organisms capable of substantial lignin decay are white rot fungi in the Agaricomycetes, which also contains non–lignin-degrading brown rot and ectomycorrhizal species. Comparative analyses of 31 fungal...
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://www.expasy.org/sprot/), KEGG (20), and KOG (21). KEGG hits were used to assign EC
numbers (http://www.expasy.org
The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation
to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation is under tight
control, i.e. cells respond to a signal to proliferate, and although most cells...
Intraspecific life history attributes of growth, survival, and reproduction can vary in
response to changes in the physical environment. These changes can induce a cascading effect
across trophic levels. In marine systems, shifts in ocean conditions such as warm and cold phases
of ENSO can change primary production in benthic...
Intraspecific life history attributes of growth, survival, and reproduction can vary in
response to changes in the physical environment. These changes can induce a cascading effect
across trophic levels. In marine systems, shifts in ocean conditions such as warm and cold phases
of ENSO can change primary production in benthic...
We present high-resolution measurements of carbon
monoxide (CO) concentrations from a shallow ice core
of the North Greenland Eemian Ice Drilling project (NEEM-
2011-S1). An optical-feedback cavity-enhanced absorption
spectrometer (OF-CEAS) coupled to a continuous melter
system performed continuous, online analysis during a fourweek
measurement campaign. This analytical setup generated
stable...
Successful host cell colonization by the Q fever pathogen, Coxiella burnetii, requires translocation of effector proteins into
the host cytosol by a Dot/Icm type 4B secretion system (T4BSS). In Legionella pneumophila, the two-component system (TCS)
PmrAB regulates the Dot/Icm T4BSS and several additional physiological processes associated with pathogenesis. Because PmrA...
The spatial distribution and geologic histories of submarine volcanoes provide insight into submarine eruptive behavior, deep earth processes and plate tectonics. This dissertation examines the evolution of individual submarine volcanic edifices as well as linear trails of seamounts at three spatial and temporal scales.
In order to understand constructive and...
Penicillium chrysogenum is the main industrial producer of the β-lactam antibiotic penicillin, the most commonly used drug in the treatment of bacterial infections. Recently, a functional MAT1-1 locus encoding the α-box transcription factor MAT1-1-1 was discovered to control sexual development in P. chrysogenum. As only little was known from any organism...
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