The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that plays multiple roles in regulation of immune and inflammatory responses. The ability of certain AhR ligands to induce regulatory T cells (Tregs) has generated interest in developing AhR ligands for therapeutic treatment of immune-mediated diseases. To this end, we...
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that plays multiple roles in regulation of immune and inflammatory responses. The ability of certain AhR ligands to induce regulatory T cells (Tregs) has generated interest in developing AhR ligands for therapeutic treatment of immune-mediated diseases. To this end, we...
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Pennington1,
Diana Rohlman1, Edmond O’Donnell1, Patrick L. Iversen1, Siva Kumar Kolluri1,2, Nancy I
The 1995/96 reintroduction of gray wolves (Canis lupus) into Yellowstone National Park
after a 70 year absence has allowed for studies of tri-trophic cascades involving wolves, elk
(Cervus elaphus), and plant species such as aspen (Populus tremuloides), cottonwoods (Populus
spp.), and willows (Salix spp.). To investigate the status of this...
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Trophic cascades in Yellowstone: The first 15 years after wolf reintroduction
William J. Ripple ⇑, Robert
Purpose: We reviewed large-budget, National Institutes of Health (NIH)-supported randomized controlled trials (RCTs) with behavioral interventions to assess (1) publication rates, (2) trial registration, (3) use of objective measures, (4) significant behavior and physiological change, and (5) effect sizes.
Methods: We identified large-budget grants (>$500,000/year) funded by NIH (National Heart...
Purpose: We reviewed large-budget, National Institutes of Health (NIH)-supported randomized controlled trials (RCTs) with behavioral interventions to assess (1) publication rates, (2) trial registration, (3) use of objective measures, (4) significant behavior and physiological change, and (5) effect sizes.
Methods: We identified large-budget grants (>$500,000/year) funded by NIH (National Heart...
Purpose: We reviewed large-budget, National Institutes of Health (NIH)-supported randomized controlled trials (RCTs) with behavioral interventions to assess (1) publication rates, (2) trial registration, (3) use of objective measures, (4) significant behavior and physiological change, and (5) effect sizes.
Methods: We identified large-budget grants (>$500,000/year) funded by NIH (National Heart...
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,S 0.33 (.25,.41) 2.8 points on Beck
Depression
NR NR NR NR NR Fatal or
non-fatal
myocardia
l
Purpose: We reviewed large-budget, National Institutes of Health (NIH)-supported randomized controlled trials (RCTs) with behavioral interventions to assess (1) publication rates, (2) trial registration, (3) use of objective measures, (4) significant behavior and physiological change, and (5) effect sizes.
Methods: We identified large-budget grants (>$500,000/year) funded by NIH (National Heart...
Purpose: We reviewed large-budget, National Institutes of Health (NIH)-supported randomized controlled trials (RCTs) with behavioral interventions to assess (1) publication rates, (2) trial registration, (3) use of objective measures, (4) significant behavior and physiological change, and (5) effect sizes.
Methods: We identified large-budget grants (>$500,000/year) funded by NIH (National Heart...
Purpose: We reviewed large-budget, National Institutes of Health (NIH)-supported randomized controlled trials (RCTs) with behavioral interventions to assess (1) publication rates, (2) trial registration, (3) use of objective measures, (4) significant behavior and physiological change, and (5) effect sizes.
Methods: We identified large-budget grants (>$500,000/year) funded by NIH (National Heart...
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Controlled
Trials Funded by NIH Since 1980
Veronica L. Irvin, PhD, MPH1 & Robert M. Kaplan, PhD2
# The
Growing evidence indicates that disrupting the microbial community that comprises the intestinal tract, known as the gut microbiome, can contribute to the development or severity of disease. As a result, it is important to discern the agents responsible for microbiome disruption. While animals are frequently exposed to a diverse array...
