In response to genotoxic stress, ATR and ATM kinases phosphorylate H2A in fungi and H2AX in animals on a C-terminal serine.
The resulting modified histone, called γH2A, recruits chromatin-binding proteins that stabilize stalled replication forks or promote
DNA double-strand-break repair. To identify genomic loci that might be prone to replication...
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. Lynch,a* Caitlin V. Mueller,a StevenFriedman,b Michael Freitag,b Zachary A. Lewisa
Department of
In response to genotoxic stress, ATR and ATM kinases phosphorylate H2A in fungi and H2AX in animals on a C-terminal serine.
The resulting modified histone, called γH2A, recruits chromatin-binding proteins that stabilize stalled replication forks or promote
DNA double-strand-break repair. To identify genomic loci that might be prone to replication...
Nonalcoholic fatty liver disease is a major public health concern in the obese and type 2 diabetic populations. The high-fat lard diet induces obesity and fatty liver in C57BL/6J mice and suppresses expression of the PPAR-target gene, FA elongase 5 (Elovl5). Elovl5 plays a key role in MUFA and PUFA...
Several uranium anomalies, with concentrations of U₃0₈ that
average below 0.003 percent and reach maximums of 0.069 percent,
are associated with black, fossiliferous, pyritic parts of the Ordovician
Ledbetter Slate in northern Stevens County, Washington. The most
uraniferous parts of the slate occur in small (average of 5 by 30...
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of carbonate minerals was aided by the staining methods
described by Friedman (1959).
The colors
Four formations of the Cretaceous Nanaimo Group crop out on Galiano Island and on Parker and Gossip Islands, nearby. These formations are: early Campanian Geoffrey Formation which encloses a tongue of the Northumberland Formation; early Campanian to late Maestrichtian Spray Formation; and Maestrichtian Gabriola Formation. The stratigraphic succession has a...
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Steven (1960) facilitated identi-
fication of potassic and sodic feldspars. Determination of plagioclase
Major disasters are taking an ever-increasing toll on American
communities. To cope with this growing problem, Benton County is
seeking to adopt an alternative approach known as Community-
Based Emergency Preparedness. Its goal is to improve collaboration
among governmental agencies and the public to gain greater
flexibility in decision-making and...
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me all the way
to the end: Sally Davenport, Leonard Friedman, Robert Lawrence,
Charles Rosenfeld