Coibamide A is a methyl-stabilized cyclic depsipeptide with a lariat side chain that was isolated from a marine cyanobacterium as part of an International Cooperative Biodiversity Groups program based in Panama. Previous testing of this potent and selective growth-inhibitory agent in the National Cancer Institute (NCI) in vitro 60 human...
Natural products from both terrestrial and marine sources represent a significant source of novel drug leads, and have previously been developed into clinically-approved agents for the treatment of various human diseases. This work represents the biological characterization of the mechanistic basis for activity of several natural product structures in models...
The effects of incorporation of selected biocides on physical and mechanical properties of aspen strandboard were assessed using five copper-based preservatives or zinc borate at three retention levels. Tebuconazole or 4,5-dichloro-2-N-octyl-4-isothiazolin-3-one (DCOI) were added as co-biocides to selective copper-based treatments. Mold box tests showed that only panels treated with DCOI...
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Jeffery J. Morrell Frederick A. Kamke
The effects of incorporation of selected biocides
Chemicals must be bioavailable for there to be a potential for exposure and consequent risk to human or environmental health. Passive sampling devices (PSDs) are used to quantify the time-integrated concentration of bioavailable contaminants. We demonstrate that PSDs can be paired with the zebrafish developmental toxicity bioassay to produce site-specific,...
Accurate chromosome segregation and cell cleavage are critical to maintaining genomic integrity. Both events involve the spindle apparatus, but the exact mechanics is as puzzling as the contradicting models proposed in the last two centuries. In this dissertation, current prevailing models of chromosome segregation and cell cleavage are tested using...
An increase in anthropogenic activities since the industrial revolution, primarily due to burning of fossil fuels and changes in land cover, has resulted in a steady increase in the global mean atmospheric CO2 concentrations. While there is unequivocal scientific evidence on global warming and its multidimensional impacts on natural and...
Riparian zones are ecotones between terrestrial and aquatic ecosystems. Processes in streams are strongly influenced by riparian forest communities, age, stage and structure. Temperate forests across much of North America, including riparian areas, are recovering from historic land clearing with many stands in the stem-exclusion phase of development in which...
Landscape positions have been used to determine soil properties. My soil study in Monteverde on the Pacific slope of Costa Rica was designed to examine soil-landscape relationships for sites with various land use histories and management. Soil pits were dug at Nacimiento y Vida, Crandell, Curi-cancha, La Calandria, and Finca...
Climate change is occurring at an increasingly rapid rate, with impacts heightened in the cold regions of the world including the Arctic. Warming effects are widespread, with one impacted process – freeze-thaw cycles – increasing in frequency and potentially triggering additional changes in permafrost soils that have previously acted as...
Two distinct strategies were explored for the enantioselective synthesis of α-heteroatom substituted alkyl boronic esters by stereoselective reagent-controlled homologation using transient chiral carbenoid reagents CHYMX (Y = heteroatom, X = nucleofuge, M = electrofuge). In the first case, a stereospecific reagent-controlled homologation (sStReCH) approach to α-alkoxyalkylboronates using α-metalated S,O- and...