Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
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Manner in mdx Mice
Limin Cao1,2, Gang Han1, Caorui Lin1, Ben Gu1, Xianjun Gao1, Hong M Moulton3, Yiqi
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
Antisense oligonucleotide (AO)-mediated exon-skipping therapeutics shows great promise in correcting frame-disrupting mutations in the DMD gene for Duchenne muscular dystrophy. However, insufficient systemic delivery limits clinical adoption. Previously, we showed that a glucose/fructose mixture augmented AO delivery to muscle in mdx mice. Here, we evaluated if fructose alone could enhance...
The Laplace-Beltrami operator of a smooth Riemannian manifold is determined by the Riemannian metric. Conversely, the heat kernel constructed from the eigenvalues and eigenfunctions of the Laplace-Beltrami operator determines the Riemannian metric. This work proves the analogy on Euclidean polyhedral surfaces (triangle meshes), that the discrete heat kernel and the...
In a wireless sensor network, sensor nodes are deployed in an ad hoc fashion and they deliver data packets using multihop transmission. However, transmission failures occur frequently in the multihop transmission over wireless media. Thus, a loss recovery mechanism is required to provide end-to-end reliability. In addition, because the sensor...
Wireless LANs (WLANs) have been widely adopted and are more convenient as they are inter-connected as wireless campus networks and wireless mesh networks. However, time-sensitive multimedia applications, which
have become more popular, could suffer from long end-to-end latency in WLANs.
This is due mainly to handoff delay, which in turn...
The mitigation hierarchy is a decision-making framework designed to address impacts on biodiversity and ecosystem services through first seeking to avoid impacts wherever possible, then minimizing or restoring impacts, and finally by offsetting any unavoidable impacts. Avoiding impacts is seen by many as the most certain and effective way of...
Marine Team is a student effort to examine spatial and temporal variation of fish species within Yaquina Bay. Marine Team was developed at OSU as a seminar course with a field sampling component, to help students of marine ecology get “hands on” experience with data collection and analysis. We set...
A substantial fraction of estuarine tidal wetlands have been lost to development or other human uses in the Pacific Northwest since the 1800s. Wetland restoration, typically through tidal re-connection, can restore normal tidal hydrology to these areas and improve estuarine capacity to support ecosystem functions and services. Restoration may initiate...