Persistent and uncontrolled inflammation is the root cause of various debilitating diseases. Given that interleukin-1 receptor–associated kinase 4 (IRAK4) is a critical modulator of inflammation, inhibition of its activity with selective drug molecules (IRAK4 inhibitors) represents a promising therapeutic strategy for inflammatory disorders. To exploit the full potential of this...
As we contemplate the future of forest landscapes under changing climate conditions and land-use demands, there is increasing value in studying historic forest conditions and how these landscapes have changed following past disturbances. Historic landscape paintings are a potential source of data on preindustrial forests with highly detailed, full-color depictions...
Nickel (Ni)-based alloys with a high chromium (Cr) content are frequently employed in applications where elevated temperatures and/or corrosive environments are present due to their excellent corrosion resistance and mechanical properties. However, a gap exists around the formation, and kinetics of long-range order (LRO) Ni2Cr phase in both model binary...
Summertime low clouds are common in the Pacific Northwest (PNW), but spatiotemporal patterns have not been characterized. We show the first maps of low cloudiness for the western PNW and North Pacific Ocean using a 22‐year satellite‐derived record of monthly mean low cloudiness frequency for May through September and supplemented...
Recent warnings from scientists suggest there is limited time to enact policies to avert wide‐ranging ecological and social damage from climate change. In the United States, discussions about comprehensive national policies to avert climate change have begun, with “Green New Deal” proposals and climate plans put forth by members of...
More than half of students in Washington state community colleges enroll in developmental mathematics, but a relatively small percentage of these students persist to the second year. Many students place into these courses and never enroll; others enroll at some point after the first academic term, even when faced with...
Headwater streams and wetlands are integral components of watersheds that are critical for biodiversity, fisheries, ecosystem functions, natural resource-based economies, and human society and culture. These and other ecosystem services provided by intact and clean headwater streams and wetlands are critical for a sustainable future. Loss of legal protections for...
Sea otters fulfill a keystone role in several Northeastern Pacific nearshore ecosystems. However, their influence has been absent in Oregon coastal waters since their extirpation in the 19th and early 20th century. Interest has been growing for a translocation attempt to reintroduce sea otters to Oregon from one or more...
Background A novel equine parvovirus (EqPV-H) was recently discovered in the equine liver with Theiler's disease. Objectives To determine the prevalence of EqPV-H infection in naturally occurring Theiler's disease cases and in-contact horses in the absence of historical equine biologic product administration. Animals Ten cases of Theiler's disease from 6...
New Paleomagnetic Secular Variation (PSV) data from Fish Lake, Utah, USA, along with previously published regional records, allow us to build an independently dated Western North America PSV stack (WNAM17) from about 35 to 15 ka that quantifies dating and paleomagnetic uncertainties. In February 2014, we recovered a composite 11-m-long...