Identification of new molecular targets for the treatment of breast cancer is an important clinical goal, especially for triple-negative breast cancer, which is refractory to existing targeted treatments. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known primarily as the mediator of dioxin toxicity. However, the AhR can...
Full Text:
evaluate direct binding of raloxifene to the AhR.34 Raloxifene
displaced [3H]-3MC (Figure 2c), suggesting
Vibrio cholerae is autochthonous to various aquatic niches and is the etiological agent of the life-threatening diarrheal disease
cholera. The persistence of V. cholerae in natural habitats is a crucial factor in the epidemiology of cholera. In contrast to the
well-studied V. cholerae-chitin connection, scarce information is available about the...
Full Text:
System Links
Vibrio cholerae with Collagen
Park, B. R., Zielke, R. A., Wierzbicki, I. H., Mitchell, K
Trees from temperate latitudes transition between growth and dormancy to survive dehydration and freezing stress during winter months. We employed activation tagging to isolate a dominant mutation affecting release from dormancy, and identified the corresponding gene EARLY BUD-BREAK 1 (EBB1). We demonstrate through positioning of the tag, expression analysis, and...
Full Text:
dormancy in poplar trees
Yordanov, Y. S., Ma, C., Strauss, S. H., & Busov, V. B. (2014). EARLY
BUD-BREAK
Ligand activation of the aryl hydrocarbon (AHR) has profound effects upon the immunological status of the gastrointestinal tract, establishing and maintaining signaling networks, which facilitate host-microbe homeostasis at the mucosal interface. However, the identity of the ligand(s) responsible for such AHR-mediated activation within the gut remains to be firmly established....
Full Text:
indoles
Hubbard, T. D., Murray, I. A., Bisson, W. H., Lahoti, T. S., Gowda, K., Amin, S.
G
The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
Full Text:
. Amin4, William H. Bisson5, Yulan Liu3, Oksana Gavrilova6, Andrew D. Patterson7 &
Frank J. Gonzalez1
Gas hydrates, pervasive in continental margin sediments, are expected to release methane in
response to ocean warming, but the geographic range of dissociation and subsequent flux of methane to
the ocean are not well constrained. Sediment column thermal models based on observed water column
warming trends offshore Washington (USA) show...
Full Text:
contemporary ocean warming
Hautala, S. L., Solomon, E. A., Johnson, H. P., Harris, R. N., & Miller, U. K
We investigated dissolved methane distributions along a 6 km transect crossing active seep sites at 40 m water depth in the central North Sea. These investigations were done under conditions of thermal stratification in summer (July 2013) and homogenous water column in winter (January 2014). Dissolved methane accumulated below the...
Full Text:
methane concentrations. Each of the five
tows (Fig. 2c) took approximately 1 h and recorded 400–800
The soil bacterium Pseudomonas protegens Pf-5 can colonize root and seed surfaces of many plants, protecting them from infection by plant pathogenic fungi and oomycetes. The capacity to suppress disease is attributed to Pf-5's production of a large spectrum of antibiotics, which is controlled by complex regulatory circuits operating at...
Full Text:
1, Benjamin Philmus 2, Cedar Hesse 3, Max Kohen 1, Jeff H. Chang 1 and
Joyce E. Loper 1, 3*
1