Hyperuricemia is the condition of excessive presence of plasma uric acid ≥ 6 mg/dl. Conventional clinical/hospital urate-lowering treatment includes the administration of non-steroid anti-inflammatory drugs or xanthine oxidase inhibitors. Numerous drawbacks can be observed from these conventional treatments. In patients with refractory gout symptoms and tumor lysis syndrome, recombinant uricase...
BACKGROUND: Chronic kidney disease (CKD) and hyperuricemia often coexist and both conditions are increasing in prevalence in the U.S., although their shared role on cardiovascular risk remains highly debated.
STUDY DESIGN: Cross-sectional and longitudinal
SETTING AND PARTICIPANTS: Participants in the National Health and Nutrition Examination Survey (NHANES) from 1988 to...
While hemodialysis is a unique therapy for treating chronic kidney failure, the application of extracorporeal blood processing presents the opportunity for treating a wider range of bloodborne diseases. The objective of the i-Blood research team is to develop a blood processing device that utilizes microscale-based technology as a platform for...
Ninety-two physicians from six different medical specialty
areas were participants in an opinion survey concerning corporate
executive fitness. The survey was comprised of 21 statements
related to such areas as fitness, nutrition, implementation
of specific programs and cost effectiveness. Descriptive
research methods were utilized to analyze results.
Physicians surveyed were...
The effects of L-ascorbic acid, thiamine HC1, or L-cysteine on
acetaldehyde blood levels and disposition were investigated in acetaldehyde-
treated rats. Rats were treated with ascorbic acid (2
mmoles/kg), thiamine (0.24 mmole/kg), or cysteine (2 mmoles/kg) one
hour before the administration of acetaldehyde (6 mmoles/kg). The
results show that each...
This thesis examines the interconnection between the in vitro and in
vivo phosphorylation of rabbit muscle phosphofructokinase. The first goal
of the project was to show whether a novel site of rabbit muscle
phosphofructokinase that is subject to in vitro phosphorylation, serine 376,
may also become phosphorylated in vivo. Evidence...
Mutations to superoxide dismutase were the first proven cause of Lou
Gehrig’s disease (amyotrophic lateral sclerosis; ALS) implicating superoxide in
the selective death of motor neurons that characterizes ALS. Nitric oxide
competes effectively with superoxide dismutase for superoxide to form the
powerful oxidant peroxynitrite. Endogenous formation of peroxynitrite can kill...
The purpose of this study was to investigate the relationship
between the self-body cathexis of obese women and their attitudes
toward physical activity. Fifty inventories were used for the
research in this project. The volunteer subjects' ages ranged from
18 to 45 with a mean age of 28.9 years. The...
The methodology to perform bioequivalence studies for prodrug products has not been finalized by FDA leaving the investigators to speculate over the proper approach. This study innovatively utilized the bootstrap methods for testing in vivo bioequivalence on both parent drug and metabolite of four prodrug products: Clopidogrel, Prednisone, Allopurinol, and...
Childhood obesity prevalence is significantly higher among adolescent 12-19 years old than younger age groups. Youth athletes are overlooked by childhood obesity prevention programs. WAVE~Ripples for Change (WAVE) program is a 2-y obesity prevention intervention with high school (HS) soccer players (14-19y) using a mixed virtual- and physical-world learning environment...