Index Catalog // ScholarsArchive@OSU

Inhibitory Effect of Paclitaxel and Rapamycin Individual and Dual Drug-Loaded Polymeric Micelles in the Angiogenic Cascade

Creator:: Mishra, Gyan P., Nguyen, Duc, and Alani, Adam W. G.
Abstract:: Angiogenesis is an essential process for disease progression in many solid tumors. There are several major cascade events in the angiogenic process that can be targeted to inhibit new blood vessel formation in the tumor tissue. The purpose of this work is to evaluate the inhibitory effect of paclitaxel (PTX)...
Resource Type:: Article
Full Text:: Individual and Dual Drug-Loaded Polymeric Micelles in the Angiogenic Cascade Inhibitory Effect of

Antiangiogenic Effect of Docetaxel and Everolimus as Individual and Dual-Drug-Loaded Micellar Nanocarriers

Creator:: Mishra, Gyan P., Doddapaneni, Bhuvana Shyam, Nguyen, Duc, and Alani, Adam W. G.
Abstract:: PURPOSE: The in vitro inhibitory effect of Docetaxel (DTX) and Everolimus (EVR) alone and together in poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-b-PLA) nanocarriers on angiogenic processes and acute toxicity in mice was evaluated. METHODS: PEG-b-PLA DTX and/or EVR nanocarriers were characterized for size, drug loading, stability, and drug release. Cell proliferation, tubule...
Resource Type:: Article
Full Text:: as Individual and Dual-Drug-Loaded Micellar Nanocarriers Antiangiogenic effect of Docetaxel and

Development of Micellar and Nanoparticle Structures based on Polyester Diblock Copolymer Platform for the Treatment of Metastatic Tumors

Creator:: Doddapaneni, Bhuvana S.
Abstract:: Poor aqueous solubility of a large number of newly discovered chemical entities is posing a significant challenge for the formulation industry and is delaying their drug development. The number of formulation techniques available to solubilize these poorly soluble molecules is very limited. In addition to that, traditional formulation methods involve...
Resource Type:: Dissertation
Full Text:: polymeric micelles [24]. The structure and the size of the micelle coronas formed depend on the strength

Nanomedicine Drug Delivery for the Treatment of Lymphatically Metastasizing Cancers

Creator:: Cote, Brianna M.
Abstract:: Nearly 80% of solid tumors, such as melanoma, metastasize via the lymphatic system. The most common form of melanoma is BRAF-mutant melanoma, and additional mutations, such as a PTEN mutation in the PI3K pathway, is required for metastases to occur. Standard therapy includes treatment with small molecules dabrafenib (DAB) and...
Resource Type:: Dissertation
Full Text:: DRUG DELIVERY CHALLENGES AND OPPORTUNITIES Due to the involvement of the lymphatics in spreading

Nanotheraputic Platforms to address Chemotherapeutic Challenges in Breast and Ovarian Cancer Treatment

Creator:: Al Fatease, Adel
Abstract:: Utilizing nanocarrier based drug delivery for improving the magnitude of efficacy of chemotherapeutic agents in many diseases has acquired more attention in research applications. It has shown promising results in both preclinical and clinical trials. The Food and Drug Administration (FDA) has approved many of these polymeric carriers, and tens...
Resource Type:: Dissertation
Full Text:: polymeric micelles’ biodistribution is three times higher than that of the free drug in the tumor and

Characterization and Validation of Neisseria gonorrhoeae Proteins GmhAGC and NGO1985 as Molecular Targets for Development of Novel Anti-gonorrhea Therapeutic Interventions

Creator:: Wierzbicki, Igor H.
Abstract:: The sexually transmitted disease gonorrhea, caused by the Gram-negative bacterium and obligate human pathogen Neisseria gonorrhoeae, remains a significant health and economic burden worldwide. In the absence of a protective vaccine, antimicrobial agents are the only pharmacological intervention for patients with gonorrhea. However, due to the remarkable ability of gonococcus...
Resource Type:: Dissertation
Full Text:: growth conditions mimicking the human host environment, and high attenuation in the murine model of

Development of Novel Therapeutic Approach for Ewing’s Sarcoma Treatment

Creator:: Sabei, Fahad Yahya
Abstract:: Ewing sarcoma (EwS) is the second most highly malignant tumor that arises mainly from bone and surrounding soft tissue of adolescent and young adult patients. Despite the advances in Ewing sarcoma treatment that today include a combination of five chemotherapeutic agents, surgery, and/or radiotherapy, these therapies have demonstrated limited improvement...
Resource Type:: Dissertation
Full Text:: from bone and surrounding soft tissue of adolescent and young adult patients. Despite the advances in

Investigating Multimodal Therapies with Nanotechnology to Engineer Advanced Chemoradiation Platforms

Creator:: DuRoss, Allison N.
Abstract:: The potential for nanomedicine to reduce toxicity and improve therapeutic response to radiation is vast. Clinically, this potential has thus far only begun to be realized with the recent success of the radioenhancing nanoparticle, NBTXR3 by Nanobiotix. Radioenhancing nanoparticles, however, represent only a small class of nanomaterials that may be...
Resource Type:: Dissertation
Full Text:: provide benefits in both categories, dose-enhancement and drug-delivery. Clearly, there is a plethora of

HackmanPolymericMicellesCarriersNerveHighlightingFluorescent.pdf

Creator:: Hackman, Kayla M., Doddapaneni, Bhuvana Shyam, Barth, Connor W., Wierzbicki, Igor H., Alani, Adam W. G., and Gibbs, Summer L.
Abstract:: Nerve damage during surgery is a common morbidity experienced by patients that leaves them with chronic pain and/or loss of function. Currently, no clinically approved imaging technique exists to enhance nerve visualization in the operating room. Fluorescence image-guided surgery has gained in popularity and clinical acceptance over the past decade...
Full Text:: rapamycin individual and dual drug-loaded polymeric micelles in the angiogenic cascade. Molecular

HackmanPolymericMicellesCarriersNerveHighlightingFluorescentVOR.pdf

Creator:: Hackman, Kayla M., Doddapaneni, Bhuvana Shyam, Barth, Connor W., Wierzbicki, Igor H., Alani, Adam W. G., and Gibbs, Summer L.
Abstract:: Nerve damage during surgery is a common morbidity experienced by patients that leaves them with chronic pain and/or loss of function. Currently, no clinically approved imaging technique exists to enhance nerve visualization in the operating room. Fluorescence image-guided surgery has gained in popularity and clinical acceptance over the past decade...
Full Text:: . P.; Nguyen, D.; Alani, A. W. Inhibitory effect of paclitaxel and rapamycin individual and dual drug

ScholarsArchive@OSU

Inhibitory Effect of Paclitaxel and Rapamycin Individual and Dual Drug-Loaded Polymeric Micelles in the Angiogenic Cascade

Antiangiogenic Effect of Docetaxel and Everolimus as Individual and Dual-Drug-Loaded Micellar Nanocarriers

Development of Micellar and Nanoparticle Structures based on Polyester Diblock Copolymer Platform for the Treatment of Metastatic Tumors

Nanomedicine Drug Delivery for the Treatment of Lymphatically Metastasizing Cancers

Nanotheraputic Platforms to address Chemotherapeutic Challenges in Breast and Ovarian Cancer Treatment

Characterization and Validation of Neisseria gonorrhoeae Proteins GmhAGC and NGO1985 as Molecular Targets for Development of Novel Anti-gonorrhea Therapeutic Interventions

Development of Novel Therapeutic Approach for Ewing’s Sarcoma Treatment

Investigating Multimodal Therapies with Nanotechnology to Engineer Advanced Chemoradiation Platforms

HackmanPolymericMicellesCarriersNerveHighlightingFluorescent.pdf

HackmanPolymericMicellesCarriersNerveHighlightingFluorescentVOR.pdf

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