Understanding the precise role of the immune system in cancer has been hindered by the complexity of the immune response and challenges in measuring immune cell types in health and disease in the context of large epidemiologic studies. In this review, we present the rationale to study immunity in cancer...
The myeloid-specific transcription factor, CCAAT/enhancer-binding protein epsilon (C/EBPε) is a critical mediator of myelopoiesis. Mutation of this gene is responsible for neutrophil-specific granule deficiency in humans, a condition that confers susceptibility to Staphylococcus aureus infection. We found that C/EBPε-deficient mice are severely affected by infection with S. aureus, and C/EBPε...
For more than 35 years we have known that the accuracy of DNA replication is controlled in
large part by the relative concentrations of the four canonical deoxyribonucleoside 5'-triphosphates (dNTPs) at the replisome. Since this field was last reviewed, about eight years ago,
there has been increased understanding of the...
The treatment of certain types of cancers brings with it serious physiological and
psychological side effects in cancer survivors, including: decreased aerobic capacity,
muscle wasting, body composition changes, fatigue, and a diminished overall quality of
life. Exercise may directly influence the physiological side effects of cancer and cancer
treatment, and...
A liquid crystal thermographic technique was developed
for application to several problems in clinical
medicine and physiology. The procedure was inexpensive,
rapid, simple, versatile and acceptable to patients.
Investigators in the past have used cholesteric liquid
crystals for thermography but their use was limited to
research in the medical field...