Meniscal tears are a common cause of stifle lameness in dogs. Use of autologous
synoviocytes from the affected stifle is an attractive cell source for tissue engineering
replacement fibrocartilage. However, the diseased state of these cells may impede
in vitro fibrocartilage formation. Synoviocytes from 12 osteoarthritic (“oaTSB”) and
6 normal...
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, Schmid E, Bau B, Harley V, Poschl E. 2003. SOX9 expression does not
correlate with type II collagen
Histone deacetylase (HDAC) inhibitors are undergoing clinical trials as anticancer agents, but some exhibit resistance mechanisms
linked to anti-apoptotic Bcl-2 functions, such as BH3-only protein silencing. HDAC inhibitors that reactivate BH3-only family
members might offer an improved therapeutic approach. We show here that a novel seleno-α-keto acid triggers global histone...
Anecdotal accounts of tiludronate administration via intravenous regional limb
perfusion (IVRLP) exist despite a lack of information regarding safety for synovial
structures in the perfused area. The objective of this study was to determine whether
tiludronate concentrations in synovial structures after IVRLP with low dose (0.5 mg,
LDT) or high...
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.
Coudry V, Thibaud D, Riccio B, Audigie F, Didierlaurent D, Denoix JM. 2007. Efficacy of
tiludronate in
Background:
The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity. The current investigation sought to examine the relationships between Nrf2 status and HDAC expression in preclinical and translational studies.
Results:
Wild type...
Background:
The dietary agent sulforaphane (SFN) has been reported to induce nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2)-dependent pathways as well as inhibiting histone deacetylase (HDAC) activity. The current investigation sought to examine the relationships between Nrf2 status and HDAC expression in preclinical and translational studies.
Results:
Wild type...
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, member of
ETS oncogene
family
1.00 2.69 1.37 1.45 1.16 1.03 1.56 1.37
23 Erbb2
V-erb-b2
Dibenzo(def,p)chrysene (DBC), (also known as dibenzo[a,l]pyrene), is a high molecular weight
polycyclic aromatic hydrocarbon (PAH) found in the environment, including food, produced by
the incomplete combustion of hydrocarbons. DBC, classified by IARC as a 2A probable human
carcinogen, has a relative potency factor (RPF) in animal cancer models 30-fold higher...
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) Castro, D. J., Baird, W. M., Pereira, C. B., Giovanini, J., Löhr, C.
V., Fischer, K. A., Yu, Z
Background:
Over 650 million people worldwide lack access to safe water supplies, and even among those who have gained access to ‘improved’ sources, water may be seasonally unreliable, far from homes, expensive, and provide insufficient quantity. Measurement of water access at the level of communities and households remains crude, and...
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, Cumming O, Curtis V, et al. Burden of disease from
inadequate water, sanitation and hygiene in low- and
Cisplatin (CDDP) is a highly active platinum-containing chemotherapeutic agent for use against solid tumors, including ovarian. However, like most antitumor agents, CDDP use is accompanied by non-tumor tissue toxicities leading to unwanted side effects, including neuropathy. To date, the mechanism(s) for these side effects are undefined. However, the clinical features...
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ChristianeLöhr, DVM, Ph.D.
F344 Rats
Kevin Ahern, Ph.D.
ACS Research Scholar grant 120548-RSG-11-075-01-CCE
Lung cancer in humans is an adult-onset disease. It is the number one cause of cancer mortality for both men and women and has a poor (15%) survival rate. Biological markers of the disease would allow for early diagnosis and treatment. The specific aims of this research project were to...
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transplacentally exposed to the environmental contaminant DBC
David A. Sampson1, 2, ChristianeV. Löhr6, Kate G
