The potent antitumor agent phorboxazole A was synthesized from six subunits comprising C1-C2 (115), C3-C8 (98), C9-C19 (74), C20-C32 (52), C33-C41 (84) and C42-C46 (85). Tetrahydropyrans B and C containing cis-2,6-disubstitution were fabricated via palladium(II)-mediated intramolecular alkoxycarbonylation which, in the case of tetrahydropyran C, was carried out with catalytic palladium(II)...
The total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, is described. Both a palladium(II)-mediated and a palladium(II)-catalyzed intramolecular alkoxycarbonylation were used as key steps for the preparation of the two cis-2,6-disubstituted tetrahydropyran rings (C22-C26 and C11-C15) of phorboxazole A.
The synthesis used a convergent approach involving...
The relationships between types of wealth components and consumption
expenditures were investigated as a means of better understanding retired
elderly household well-being. Specifically, the concept of mental account was
used to identify the characteristics of different types of wealth components, and
four mental accounts were identified: flow of investment, current...
Geographers and regional scientists have long recognized that "near things are more related than distant things." Ports located far from each other may compete through use of the same fishing grounds. We describe trends in competition in the Northeast U.S Sea Scallop Fishery using a Czekanowski Index over the past...
Hedonic models reveal the marginal implied prices of attributes; these premia represent the intersection of supply and demand for those attributes. Understanding the demand for these attributes is critical for policy analysis that may influence those attributes. While Rosen (1974) proposes a two-step method to recover demand, Kristofersson and Rickertsen...
Wireless LANs (WLANs) have been widely adopted and are more convenient as they are inter-connected as wireless campus networks and wireless mesh networks. However, time-sensitive multimedia applications, which
have become more popular, could suffer from long end-to-end latency in WLANs.
This is due mainly to handoff delay, which in turn...
The North Atlantic U.S. groundfish and scallop processing industries are a tale of two fisheries. The groundfish processing industry has suffered a steep, almost continual decline in landings starting in 1984 that resulted in 2014 landings that were only 16% of 1983 landings. US scallop landings increased from 5 million...
This research develops a spatially-explicit model of recreational angler participation in an effort to predict outcomes for the US summer flounder (fluke) fishery under alternative climate scenarios, and inform adaptive management approaches. The mid-Atlantic coastal waters of the US have experienced significant warming in recent years, resulting in noticeable pole-ward...
New Bedford’s share of Atlantic sea scallops landings and revenues increased from 44% in 1996 to 67% in 2013. Explanations for industrial agglomerations often focus on the relative importance of natural advantage and economies of scale or scope. We use the absolute and relative Theil indices of disproportionality to examine...
The current study investigates gender differences in behavioral regulation in four societies: the United States, Taiwan, South Korea, and China. Directly assessed individual behavioral regulation(Head–Toes–Knees–Shoulders, HTKS), teacher-rated classroom behavioral regulation (Child Behavior Rating Scale, CBRS) and a battery of school readiness assessments (mathematics, vocabulary, and early literacy) were used with...