In this report, three studies are presented that aid in the development of drug discovery and their synthesis. In each, the importance of the marriage between computations and experiments is highlighted. Continued efforts in this vein are essential for future efforts towards improving human health.
The first case study investigated...
Low carbon steels (LCS) due to their high strength-to-cost ratio are one of the most ubiquitous materials used for a wide range of applications, including but not limited to automotive, construction, and transportation. However, the low corrosion resistance of LCS in neutral, acidic, or saline environments limits its utilization and...
Systems biology is becoming increasingly important for the study of living organisms. It focuses on the mathematical understanding of biological systems. Cells, the basic units of all living creatures, are biological systems of major interest. Considerable work is being done towards modeling cells as mathematical systems. At the same time,...
Mandelalide A has attracted considerable interest from the synthetic community due to its intriguing structure and important cytotoxic activity. Madeirolide A, a structurally related macrolide, shows promising antifungal activity but no appreciable anticancer activity. This dissertation describes synthetic studies toward mandelalide A, madeirolide A and their hybrid structures.
Part I...
To obtain a mechanistic understanding of the chemical processes, techniques that offer a frame-by-frame visualization of molecular structure during a reaction are of vital importance. Numerous efforts and advances have been made in order to acquire such vivid molecular “movies”, especially in the electronic excited state. Ultrafast molecular spectroscopy method...
The enormous success of wireless technology has recently led to an explosive demand for, and hence a shortage of, bandwidth resources. This expected shortage problem is reported to be primarily due to the inefficient, static nature of current spectrum allocation methods. As an initial step towards solving this shortage problem,...
IoT networks can be viewed as collections of Internet-enabled physical devices and objects, embedded with sensor, actuator, computation, storage and communication components, that are capable of connecting and exchanging data to one another. In recent years, organizations have allowed more and more IoT devices to be connected to their networks,...
In this work, we study network coding technique, its relation to random matrices, and their applications to communication systems. The dissertation consists of three main contributions. First, we propose efficient algorithms for data synchronization via a broadcast channel using random network coding. Second, we study the resiliency of network coding...
Magnetic thin films have potential to improve devices such as on-chip inductors, and enable new technologies such as magnetic random access memory (MRAM).
The use of magnetic cores in on-chip inductors is typically limited to applications well under 1 GHz. At higher frequencies, the performance of the magnetic core is...
In this thesis, I present a new method we developed to study low frequency (< 700 cm⁻¹) vibrational dynamics: Time-resolved third-harmonic generation (TRTHG) spectroscopy. Among a variety of vibrational spectroscopy techniques, TRTHG differentiates itself with robustness, versatility, and simplicity. In TRTHG experiment, that involves only two ultrashort laser pulses, the...