Dibenzo[def,p]chrysene (DBC) is a highly potent, but less prevalent, environmental carcinogen belonging to a class of compounds known as Polycyclic Aromatic Hydrocarbons (PAHs). They are highly ubiquitous and arise as a byproduct of natural and anthropogenic combustion processes. Previous studies have documented carcinogenic effects upon in utero exposure of PAHs....
Understanding the precise role of the immune system in cancer has been hindered by the complexity of the immune response and challenges in measuring immune cell types in health and disease in the context of large epidemiologic studies. In this review, we present the rationale to study immunity in cancer...
Proteinase P-II purified from parasitized Pacific whiting muscle was previously
identified to be one form of cathepsin L. It appeared to be present in three isozymatic
forms on non-denaturing PAGE gel stained for activity. Its autolytic degradation was
observed on SDS-PAGE gel under its optimum condition, 55°C and pH 5.5,...
Embryonic development, where organs and major structures begin to develop, requires precise coordination of numerous gene regulatory pathways. Fendrr is an long non-coding RNA (lncRNA) that plays a role in regulating gene expression in mesodermal tissues during early embryonic development in mouse. The lateral plate mesoderm (LPM) is an earlier...
Dibenzo[def,p]chrysene (DBC) is a highly potent, but less prevalent, environmental carcinogen belonging to a class of compounds known as Polycyclic Aromatic Hydrocarbons (PAHs). They are highly ubiquitous and arise as a byproduct of natural and anthropogenic combustion processes. Previous studies have documented carcinogenic effects upon in utero exposure of PAHs....
The rapid growth in the number of roundabouts raises some significant research challenges, especially around safety performance and evaluation in the U.S. Despite the safety advantages that roundabout geometric design brings, crashes still occur. While operationally roundabouts are good at preventing severe crashes, they may lead to more less severe...
High proteolytic activity Pacific whiting muscle causes hydrolysis of myofibrillar protein and lowers surimi gel quality. Although food grade proteinase inhibitors can be used to prevent autolytic activity in surimi, their usage is limited due to their adverse effects on the organoleptic quality of surimi. Cystatins however can be used...
Proteolytic degradation of fish flesh occurring at elevated temperatures is the
primary limitation for the commercial utilization of arrowtooth flounder (ATF).
Characterization of the autolytic activity of ATF muscle incubated at various pHs
and temperatures indicated the involvement of heat-activated proteinases active at
acidic and alkaline pHs. Further characterization of...
A partial cystatin cDNA from rainbow trout was
generated by reverse transcription polymerase chain reaction
with two degenerate primers. The partial cystatin PCR
product was 168 bp and used to screen trout liver λgt 11
cDNA library. Four positive clones were isolated and
designated as cstl, cst2, cst3 and cst4....