Using a systems biology approach, we discovered and dissected a three-way interaction between the immune system, the intestinal epithelium and the microbiota. We found that, in the absence of B cells, or of IgA, and in the presence of the microbiota, the intestinal epithelium launches its own protective mechanisms, upregulating...
Lactose intolerance is a common food intolerance that occurs because of a post-weaning deficiency of lactase, an enzyme that cleaves the glyosidic bond of lactose. About 75% of the world's population is lactose intolerant. Common symptoms of lactose intolerance are abdominal pain, bloating and diarrhea. ~25% of the world’s population...
Introduction: In the US, irritable bowel syndrome (IBS) affects 1 in 10 people. IBS is a chronic functional gastrointestinal disorder that consists of many gastrointestinal symptoms such as abdominal pain, changes in bowel movement, differences in the appearance of stool, diarrhea, constipation, increased gas, and mucus in stool. IBS causes...
Common variable immunodeficiency (CVID) is the most common primary immunodeficiency that is characterized by low immunoglobulin levels in the body. CVID is indicated by failure of b cell differentiation and decrease production of immunoglobulins such as IgG and at least one of IgA or IgM. CVID patients with enteropathy (E-CVID)...
This bibliography contains over 1,000 references on health issues in Borneo, organized under 18 topical headings. These reports relate to the past and present health of all the large ethnic groups on the island but few of the smaller ones, since they have received less attention. The bibliography contains textual...
The Hazard Analysis and Critical Control Point (HACCP) system for
studying the food preparation process was conducted in four households in an
environmentally poor urban neighborhood of Guayaquil, Ecuador. The analysis
consisted of observing all of the steps in the food preparation process, measuring
food temperatures at each step, and...
The ability of mercury to inhibit β - galactosidase activity from
cell-free extracts of Streptococcus lactis, Escherichia colt and
intestinal homogenates of hogs, female rats, and humans was studied. Mercuric acetate was added in vitro to all sources of β - galactosidase except for the rats, which were placed on...
BACKGROUND: Little is known about α-tocopherol’s bioavailability
as a constituent of food or its dependence on a subject’s age.
OBJECTIVE: To evaluate the α-tocopherol bioavailability from food,
we used collard greens grown in deuterated water (²H collard
greens) as a source of deuterium-labeled (²H) α-tocopherol consumed
by younger and older...
Celiac disease, an autoimmune response triggered by the consumption of seed storage proteins of cereals, affects an estimated 1% of the human population. In the case of wheat (Triticum aestivum L.), one of the world’s most consumed cereals, alcohol-soluble proteins, the gliadins, have been identified as the allergy-eliciting agents. Previous...